A5074457059- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Bowel Disease
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Alcohol Consumption and Health Effects
- Cancer survivorship and care
- Eosinophilic Disorders and Syndromes
- Hepatitis B Virus Studies
- Eosinophilic Esophagitis
- Organ Transplantation Techniques and Outcomes
- Vascular Malformations and Hemangiomas
- Advanced X-ray and CT Imaging
- Drug-Induced Hepatotoxicity and Protection
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Tumors and Oncological Cases
- Ear and Head Tumors
- Chronic Lymphocytic Leukemia Research
- Liver physiology and pathology
- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
University of North Carolina at Chapel Hill
2015-2024
University of Exeter
2019-2024
Royal Devon & Exeter NHS Foundation Trust
2023-2024
Geisinger Health System
2024
Queen's Hospital
2008-2024
Medical College of Wisconsin
2022-2024
Trinity Health
2024
American Association for the Study of Liver Diseases
2023
Barking, Havering And Redbridge University Hospitals NHS Trust
2010-2021
Medical University of South Carolina
2019
Despite recent advances in treatment of viral hepatitis, liver-related mortality is high, possibly owing to the large burden advanced alcohol-related liver disease (ALD). We investigated whether patients with ALD are initially seen at later stages development than hepatitis C virus (HCV) infection or other etiologies.We performed a cross-sectional study 3453 consecutive either early (1699 and 1754 disease) 17 tertiary care gastrointestinal units worldwide, from August 2015 through March...
Guidelines remain unclear over whether patients with early stage oral cancer without overt neck disease benefit from upfront elective dissection (END), particularly those the smallest tumours.
Summary Background Seasonal variation has been reported in diagnosis of eosinophilic oesophagitis (EoE), but results are not consistent across studies and there no national‐level data the USA. Aim To determine if is seasonal oesophageal eosinophilia EoE USA, while accounting for factors such as climate zone geographic variation. Methods This was a cross‐sectional study using USA national pathology database. Patients with (≥15 eosinophils per high‐power field) comprised primary case...
Risk of alcoholic cirrhosis is determined by genetic and environmental factors. We aimed to investigate if climate has a causal effect on alcohol consumption its weight cirrhosis. collected extensive data from 193 sovereign countries as well 50 states 3,144 counties in the United States. Data sources included World Health Organization, Meteorological Institute Metrics Evaluation. Climate parameters comprised Koppen‐Geiger classification, average annual sunshine hours, temperature. Alcohol...
Verrucous carcinoma of the esophagus is a variant squamous cell cancer. Our case 78-year-old male patient comes in with dysphagia and weight loss, on endoscopy (EGD) he found to have an irregular intraluminal mass at distal esophagus. With deep EGD assisted biopsy, diagnosis verrucous made. Due multiple co morbidities possible infiltration pericardium, taken for esophageal stent placement being referred chemo-radiation treatment. The can be very difficult make superficial biopsies due non...
Crohn's disease (CD) is highly heterogeneous, due in large part to variability cellular processes that underlie the natural history of CD, thereby confounding effective therapy. There a critical need advance understanding mechanisms drive CD heterogeneity.We performed small RNA sequencing adult colon tissue from and NIBD controls. Colonic epithelial cells immune were isolated colonic tissues, microRNA-31 (miR-31) expression was measured. miR-31 measured colonoid cultures generated controls...
Lieber, Sarah R. M.D., M.S.C.R.; Kim, Hannah P. Baldelli, Luke M.D.; Evon, Donna M. Ph.D.; Teal, Randall M.A.; Nash, Rebekah Magee, Gabrielle Desai, Chirag S. Gerber, David Serrano, Pablo Shah, Neil Barritt, A. Sidney IV M.S.C.R. Author Information
Abstract Background and Aims Anti-tumour necrosis factor [anti-TNF] therapy is widely used for the treatment of inflammatory bowel disease, yet many patients are primary non-responders, failing to respond induction therapy. We aimed identify blood gene expression differences between responders non-responders anti-TNF monoclonal antibodies [infliximab adalimumab], predict response status from clinical data. Methods The Personalised Anti-TNF Therapy in Crohn’s Disease [PANTS] study a UK-wide...
ABSTRACT Balamuthia mandrillaris is a rare cause of human infection, but when infections do occur, they result in high rates morbidity and mortality. A case disseminated infection presented. Early diagnosis initiation recommended therapy are essential for increased chances successful outcomes.
Background: Patient-reported outcomes (PRO) measures relevant to domains most important patients with HCC who received locoregional therapies are needed advance patient-centered research. Furthermore, electronic PRO monitoring in clinical care has been shown reduce hospitalizations and deaths other cancers. We conducted a qualitative study among recently (1) identify common distressing posttreatment symptoms prioritize domain selection (2) gauge interest an symptom system. Methods: performed...
The liver is a rare site for anastomosing hemangiomas with only few cases reported that characterize the lesions on magnetic resonance imaging (MRI). These may be underreported due to overlapping features classic hemangiomas. Anastomosing have well-defined histological profile and are often diagnosed by biopsy in setting of atypical features. We report case biopsy-proven hepatic hemangioma found screening MRI hepatocellular carcinoma 52-year-old female cirrhosis. This lesion initially...
We present a case of pericardial amyloidosis with associated lymphoplasmacytic lymphoma in patient chronic worsening shortness breath and cough. This highlights the wide variation presentation cardiac amyloidosis, rare occurrence clinically significant light-chain heavy-chain pericardium. (Level Difficulty: Advanced.).