A5091715846- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Bioinformatics and Genomic Networks
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Metabolism and Genetic Disorders
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Blood disorders and treatments
- Colorectal Cancer Treatments and Studies
- Marine Toxins and Detection Methods
- Gene expression and cancer classification
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Cancer Genomics and Diagnostics
- Marine Bivalve and Aquaculture Studies
- Neonatal Health and Biochemistry
- Marine and coastal ecosystems
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
Hospital Erasto Gaertner
2024-2025
Hospital Israelita Albert Einstein
2024
University of Lisbon
2020-2023
Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento
2020-2023
Background/Objectives: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths rising worldwide. This leading to an increased demand for liver transplantation (LT), the most effective treatment HCC in its initial stages. However, current patient selection criteria are limited predicting recurrence and raise ethical concerns about equitable access care. study aims enhance by refining HepatoPredict (HP) tool, machine learning-based model that combines molecular clinical data...
Background Hematopoietic cell transplantation (HCT) represents a well-established therapeutic strategy for high-risk leukemia, though post-transplant relapse remains significant challenge, particularly in resource-limited settings Procedure In this retrospective study, we analyzed medical records of 310 pediatric patients (age < 18 years) who underwent HCT acute leukemias at four Brazilian institutions between 2010 and 2019. Results The cohort included with lymphoblastic leukemia...
Colorectal cancer (CRC) is the third most common and second deathly worldwide. It a very heterogeneous disease that can develop via distinct pathways where metastasis primary cause of death. Therefore, it crucial to understand molecular mechanisms underlying metastasis. RNA-sequencing an essential tool used for studying transcriptional landscape. However, high-dimensionality gene expression data makes selecting novel metastatic biomarkers problematic. To distinguish early-stage CRC patients...
Colorectal cancer (CRC) is one of the leading causes mortality and morbidity in world. Being a heterogeneous disease, therapy prognosis represent significant challenge to medical care. The molecular information improves accuracy with which patients are classified treated since similar pathologies may show different clinical outcomes other responses treatment. However, high dimensionality gene expression data makes selection novel genes problematic task. We propose TCox, penalization function...
Abstract Hematopoietic stem cell transplantation (HSCT) is an established treatment for selected patients with inborn errors of metabolism. In this first report from the PDWP-SBTMO, we included 105 transplanted between 1988 and 2021 across six Brazilian HSCT centers. The most prevalent diseases were X-linked adrenoleukodystrophy(n=61) mucopolysaccharidosis (type I n=20; type II n=10), a median age at 8.7years 2.1years, respectively. Most conditioning regimens myeloablative busulfan-based....
Summary Aplastic anaemia in infants and young children presents unique challenges due to high prevalence of inherited bone marrow failure syndromes (IBMFS) this age group. The objective study is assessing clinical characteristics outcomes haematopoietic cell transplantation ≤5 years with syndromes. We analysied 106 patients (66% males), median 4.6 years, including 40 Fanconi (FA), 32 Acquired Severe (aSAA), 15 Diamond–Blackfan Anaemia, 11 Amegakaryocytic Purpura 8 other IBMFS. Molecular...
Background/Objectives: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths rising worldwide. This leading to an increased demand for liver transplantation (LT), the most effective treatment HCC in its initial stages. However, current patient selection criteria are limited predicting recurrence and raise ethical concerns about equitable access care. study aims enhance by refining HepatoPredict (HP) tool, machine learning-based model that combines molecular clinical data...
Clear cell renal carcinoma (ccRCC) is the most common subtype of RCC showing a significant percentage mortality. One priorities kidney cancer research to identify RCC-specific biomarkers for early detection and screening disease. With development high-throughput technology, it now possible measure expression levels thousands genes in parallel assess molecular profile individual tumors. Studying relationship between gene survival outcome has been widely used find associated with survival,...