A5052217593- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Spine and Intervertebral Disc Pathology
- Helicobacter pylori-related gastroenterology studies
- Spinal Fractures and Fixation Techniques
- Gastric Cancer Management and Outcomes
- Diabetes Treatment and Management
- Gastroesophageal reflux and treatments
- Diet and metabolism studies
- Pelvic and Acetabular Injuries
- IgG4-Related and Inflammatory Diseases
- Eosinophilic Esophagitis
- Gut microbiota and health
- Alcohol Consumption and Health Effects
- Multiple Myeloma Research and Treatments
- Metabolism, Diabetes, and Cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Musculoskeletal pain and rehabilitation
- Intestinal and Peritoneal Adhesions
- Peptidase Inhibition and Analysis
- Hepatitis Viruses Studies and Epidemiology
- Cervical and Thoracic Myelopathy
- Lipoproteins and Cardiovascular Health
Mount Elizabeth Hospital
2024
National University of Singapore
2019-2021
Sengkang General Hospital
2020-2021
Changi General Hospital
2017-2020
Yong In University
2020
SingHealth
2018
Chinese University of Hong Kong
2014-2018
Swedish Medical Center
2009-2015
Middlemore Hospital
2013-2014
Counties Manukau District Health Board
2013-2014
Despite recent advances in treatment of viral hepatitis, liver-related mortality is high, possibly owing to the large burden advanced alcohol-related liver disease (ALD). We investigated whether patients with ALD are initially seen at later stages development than hepatitis C virus (HCV) infection or other etiologies.We performed a cross-sectional study 3453 consecutive either early (1699 and 1754 disease) 17 tertiary care gastrointestinal units worldwide, from August 2015 through March...
We compared the effects of weight loss induced with glucagon-like peptide-1 agonist liraglutide, that lifestyle modification, followed by maintenance after discontinuing intervention, in obese adults non-alcoholic fatty liver disease (NAFLD).Thirty (mean age 40.7 ± 9.1 years, BMI 33.2 3.6 kg/m2 , 90% male) NAFLD defined as fat fraction (LFF) > 5% on magnetic resonance imaging without other causes hepatic steatosis were randomized to a supervised programme energy restriction plus...
We compared the effects of weight loss induced by glucagon‐like peptide 1‐agonist liraglutide with a structured lifestyle intervention in obese adults non‐alcoholic fatty liver disease ( NAFLD ). Obese (body mass index ≥30 kg/m 2 , mean 96.0 ± 16.3 kg) non‐diabetic Asian adults, diagnosed fat fraction LFF ) ≥ 5.5% on magnetic resonance imaging without other causes hepatic steatosis, were randomized to supervised program dieting (restriction 400 kilocalories/d) plus moderate‐intensity aerobic...
Abstract Background and Aim The effect of type 2 diabetes mellitus ( DM ) on morbidity mortality among hepatitis B virus HBV cirrhosis patients is poorly defined. We assess the outcomes survival. Methods A retrospective study who sought care at a sole public hospital in geographically defined region, from year 2000 to 2012. Cirrhosis complications, liver transplantations, were reviewed. Primary outcome composite liver‐related overall or orthotopic transplantation OLT ). Results Two hundred...
Proton pump inhibitors (PPIs) are widely prescribed, often without clear indications. There conflicting data on its association with mortality risk and hepatic decompensation in cirrhotic patients. Furthermore, PPI users exposure some studies have been poorly defined many confounding factors.To examine if use increases the impact of cumulative dose exposure.Data from patients decompensated liver cirrhosis were extracted a hospital database between 2013 to 2017. as daily (cDDD) ≥ 28 within...
Even though a lot of effort has gone into preventing operating at the wrong site and patient, wrong-level surgery is unique problem in spine surgery.The current method to prevent level performed mainly relied on intra-operative X-ray. Unfortunately, because features anatomy spinal column, still happens. There are situations that even with intraoperative X-ray, correct cannot be reliably identified.Examples patient whose can easily illustrated. A protocol preformed developed.The consequence...
Object The authors propose an easy MR imaging method to measure and categorize individual anatomical variations within the cervicothoracic junction (CTJ). Furthermore, they guidelines for selection of appropriate approach based on this new categorization system. Methods In midsagittal section studies obtained in 95 Chinese patients, a triangle was drawn among 3 points: suprasternal notch (SSN), midpoint anterior border C7/T1 intervertebral disc, corresponding CTJ at level SSN. angle above...
Liver cirrhosis is an important cause of morbidity and mortality; however, little known about its impact in New Zealand.We aim to determine the disease burden, epidemiology outcomes cirrhotic patients.This a retrospective study patients under secondary public hospital care geographically defined region, between years 2000 2011. Cirrhosis complications mortality was recorded. Poisson log-linear regression analysis performed for incidence rate ratio (IRR) Cox used analyse time-related...
Gastric cancer (GC)-related incidence and mortality rates remain high owing to Helicobacter pylori infection in Asia, the importance of primary secondary prevention GC has been well recognized. We aimed investigate extent overall agreement among clinicians Asia-Pacific region regarding management H. infection.
The objectives of this study were to examine the effects ethnicity, gender and a proton pump inhibitor (PPI), omeprazole, on human gut microbiome. PPIs are commonly used for treatment acid-related disorders. We hypothesised that PPI therapy might perturb microbial communities alter microbiome.Healthy subjects Chinese (n = 12), Malay 12) Indian 10) ancestry, aged 21-37 years, enrolled. They provided baseline stool sample (Day 1) then given course omeprazole at therapeutic dose (20 mg daily)...
Summary Background Delayed hepatitis B e antigen ( HB eAg) seroclearance increases the risk of cirrhosis and hepatocellular carcinoma HCC ). The effect metabolic syndrome (MetS) on eAg in chronic CHB ) patients remains unclear. Aims To examine MetS seroclearance. Methods A prospective cohort 413 treatment‐naïve eAg‐positive from 2005 to 2012 was studied. Clinical, virological histological parameters were evaluated. classified into three groups according characteristics; normal, pre‐MetS...
INTRODUCTION Linkage to care among individuals with substance misuse remains a barrier the elimination of hepatitis C virus (HCV). We aimed determine whether point-of-care (PoC) education, screening and staging for liver disease direct access hospitals would improve linkage this group. METHODS All participants were offered PoC education HCV screening. HCV-positive randomised standard (controls) or access, which provided pathway hospitals. was determined by reviewing electronic medical...
In Brief Study Design. Prospective registry of spine surgery. Objective. To identify variation in utilization, processes care, and outcomes surgery to improve statewide quality safety. Summary Background Data. Variability the utilization elective across different regions United States internationally has become a growing focus critical evaluation. 2011, surgeons Washington State created Spine Surgical Care Outcomes Assessment Program address variability use, process, outcome Methods. cohort...
Perturbance in the composition of human gut microbiota has been associated with metabolic disorders such as obesity, diabetes mellitus, and insulin resistance. The objectives this study are to examine effects ethnicity, central recorded dietary components on potentially influencing microbiome. We hypothesize that these factors have an influence microbiome.Subjects Chinese (n = 14), Malay 10), Indian 11) ancestry, a median age 39 years (range: 22-70 old), provided stool samples for microbiome...
Minimally invasive lumbar spine fusion surgery has gained popularity in recent years. Routinely, this technique requires bilateral parasagittal incisions for decompression, interbody fusion, and posterior instrumentation. The following study is a description of new minimally one-level transforaminal (TLIF) using unilateral incision (Wiltse approach), with placement pedicle screws then percutaneous transpedicular facet screw insertion on the contralateral side. biomechanical stability...
We report a case of 55-year-old woman with hypertension and diabetes mellitus, who took tamoxifen for the past 4 years. She presented acute pancreatitis caused by markedly elevated serum triglycerides (3,883 mg/dL). Tamoxifen is known to cause mild increase in triglycerides, but it rarely increases such high levels pancreatitis. The patient recovered well, was switched letrozole. It crucial monitor lipids up years beyond patients on tamoxifen, particularly dyslipidemia or mellitus.
The prohibitively high cost of direct-acting antivirals (DAA) for hepatitis C virus (HCV) infection remains a barrier to treatment access in Singapore. We aimed evaluate whether DAA as first-line therapy would be cost-effective genotype 3 (GT3) HCV patients compared with pegylated interferon and ribavirin (PR).A decision tree analysis was used compare the costs outcomes PR therapy. Treatment effectiveness, defined sustained virological response, assessed using retrospective cohort treated...