A5101971418- Intraocular Surgery and Lenses
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Anesthesia and Sedative Agents
- Intraoperative Neuromonitoring and Anesthetic Effects
- Corneal surgery and disorders
- Cerebrospinal fluid and hydrocephalus
- Mitochondrial Function and Pathology
- Pediatric Pain Management Techniques
- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Impairment Studies
- Cell death mechanisms and regulation
- Photoreceptor and optogenetics research
- Retinal Diseases and Treatments
- Peroxisome Proliferator-Activated Receptors
- Virus-based gene therapy research
- Neurosurgical Procedures and Complications
- ATP Synthase and ATPases Research
- Peripheral Neuropathies and Disorders
- Hemodynamic Monitoring and Therapy
- Metabolism, Diabetes, and Cancer
- Enhanced Recovery After Surgery
- Neuroscience and Neuropharmacology Research
Doheny Eye Institute
2023-2025
Queen Elizabeth Hospital
2024
University of Pennsylvania
2016-2024
University of Auckland
2024
Hospital of the University of Pennsylvania
2023
University of California, Los Angeles
2023
University of Ottawa
2017-2021
Ottawa Hospital
2021
Hospital for Sick Children
2018-2020
Hahnemann University Hospital
2016-2019
PER genes are essential for the biogenesis of peroxisomes in yeast Pichia pastoris. Here we describe cloning PER3 and functional characterization its product Per3p. The sequence predicts that Per3p is a 713-amino acid (81-kDa) hydrophobic protein with at least three potential membrane-spanning domains. We show membrane peroxisome. Methanol- or oleate-induced cells per3-1, mutant strain generated by chemical mutagenesis, lack normal but contain numerous abnormal vesicular structures. vesicles...
Neurodegenerative diseases (NDs) refer to a group of in which slow, continuous cell death is the main pathogenic event nervous system. Most NDs are characterized by cognitive dysfunction or progressive motor dysfunction. Treatments mainly target alleviating symptoms, and most do not have disease-modifying drugs. The pathogenesis involves inflammation apoptosis mediated mitochondrial Dantrolene, approved US Food Drug Administration, acts as RyRs antagonist for treatment malignant...
Mutations in lamin A/C result a range of tissue-specific disorders collectively called laminopathies. Of these, Emery–Dreifuss and Limb-Girdle muscular dystrophy 1B mainly affect striated muscle. A useful model for understanding both laminopathies function is the Lmna−/− mouse. We found that skeletal muscle growth satellite (stem) cell proliferation were reduced mice. Lamins C associate with lamina-associated polypeptide 2 alpha (Lap2α) retinoblastoma gene product, pRb, to regulate cycle...
Aims/Purpose: To perform post‐mortem ocular analyses in two patients with Leber hereditary optic neuropathy (LHON) caused by the m.11778G > A MT‐ND4 mutation who received lenadogene nolparvovec (AAV2‐ ND4 ) gene therapy. Methods: Two LHON an intravitreal injection of one eye and a sham other during RESCUE study. Post‐mortem histopathological molecular (ddPCR) were performed on laser‐captured retinal nerve samples. Results: Within 2 months therapy, both participants developed intraocular...
To present a cluster of cases corneal edema occurring after phacoemulsification.Regional hospital in rural Australia.This retrospective case series comprised 12 patients from single surgical list comprising 19 who developed persistent having phacoemulsification.After 6 months, the improved 1 patient. Inadvertent intraocular use balanced salt solution (BSS) preserved with benzalkonium chloride was found to be cause this serious complication.Benzalkonium concentrations commonly used...
Persistent pain is prevalent in the elderly population, although it not an inevitable part of aging.It important to understand how manage effectively old age, particularly because increasing number individuals are becoming older, or living longer.Several problems, less common younger adults, may complicate treatment pain.An accurate assessment required for most efficient strategy treatment.Challenges effective include: underreporting by patients, atypical manifestations elderly,...
To assess the relationship between qualitative diabetic retinopathy (DR) scales with precise numbers and surface area of DR lesions within Early Treatment Diabetic Retinopathy Study (ETDRS) standard seven field (S7F) region on ultrawide-field (UWF) color fundus images.In this study, we collected UWF images from adult patients diabetes. Poor-quality eyes any pathology precluding assessment severity were excluded. The manually segmented. was graded according to International Clinical (ICDR) AA...
A bstract Background: Recently an intraocular lens (IOL) has been introduced which blocks blue light. As blocking light may be to the patient's detriment, this study was designed evaluate visual function following implantation of a blue‐blocking (Acrysof Natural) IOL. Methods: Patients were recruited for non‐randomized controlled interventional study, from those attending private rural ophthalmology clinic cataract surgery ( n = 93). Only who had previously conventional IOL implanted into...
Gastric cancer (GC)-related incidence and mortality rates remain high owing to Helicobacter pylori infection in Asia, the importance of primary secondary prevention GC has been well recognized. We aimed investigate extent overall agreement among clinicians Asia-Pacific region regarding management H. infection.
Long-term horizontal optokinetic stimulation (HOKS) decreases the gain of reflex and evokes second phase afternystagmus (OKAN-II). We investigated possible molecular constituents this adaptation. used a differential display reverse transcriptase-PCR screen for mRNAs isolated from retinas rabbits that received HOKS. In each rabbit, we compared retina stimulated in posterior→anterior (preferred) direction with anterior→posterior (null) direction. Acyl-CoA-binding protein (ACBP) mRNA was one...
A 59-year-old man presents with expressive aphasia and short term memory deficits. Shortly thereafter, he started developing staring spells intermittent right hand spasms, preliminarily thought to be simple partial seizures. Subsequent MRI brain imaging was highly suggestive of herpes simplex virus (HSV) encephalitis; however, HSV PCR from cerebrospinal fluid negative. On further testing, the patient found have an autoimmune encephalitis related incidentally thymoma. His clinical...
Voltage-gated sodium channels (Nav) are crucial to the initiation and propagation of action potentials (APs) in electrically excitable cells, during past decades they have received considerable attention due their therapeutic potential. Here, we report for first time synthesis electrophysiological evaluation 16 ligands based on a 2-methylbenzamide scaffold that been identified as Nav1.1 modulators. Among these compounds, N,N'-(1,3-phenylene)bis(2-methylbenzamide) (3a) has selected evaluated...
An international phone conference on malignant hyperthermia (MH) status in China was inspired by a recent case which young healthy patient the northeast region died of fulminant MH before IV dantrolene mobilized from hospital several hours flying distance away Beijing.a This resulted joint discussion among 4 major societies: MHAUS, Malignant Hyperthermia Association US; CSA, Chinese Society Anesthesiology; CASA, American ICAA, International Academy Anesthesiology The societies met to review...
To assess whether the choice of an intraocular lens (IOL) with rigid haptics (Sensar) or IOL pliable (Acrysof) has effect on refractive stability following cataract surgery.Seventy-three patients were recruited consecutively as they returned for their 6-month visit surgery. There 37 who had received Acrysof and 36 a Sensar IOL. Each patient error measured at 1-month postoperative visit. At follow-up visit, refraction was repeated. The change in then compared between groups other factors that...
Teodorescu, Roxana MD; Liu, Henry Sadun, Alfredo A. MD, PhDEditor(s): Avery, Robert DO; Golnik, Karl C. Froment, Caroline PhD; Wang, An-Guor MD Author Information
Peripapillary vitreous traction (PVT) occurring without any underlying eye disease has been contemplated as a distinct entity from nonarteritic ischemic optic neuropathy (NAION) for many years and is sometimes difficult to differentiate classical NAION. We report 6 new cases analyze the clinical features of PVT syndrome that would expand spectrum anterior neuropathies.Prospective case series.PVT seems affect discs with small area cup-to-disc (C/D) ratio. The C/D ratio does not significantly...