A5085194045- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Alcohol Consumption and Health Effects
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Liver Diseases and Immunity
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
- Hepatitis B Virus Studies
- Diagnosis and Treatment of Venous Diseases
- Hemodynamic Monitoring and Therapy
- Hormonal Regulation and Hypertension
- Frailty in Older Adults
- Renal function and acid-base balance
- Eicosanoids and Hypertension Pharmacology
- Gut microbiota and health
- Nitric Oxide and Endothelin Effects
- Electrolyte and hormonal disorders
- Diet and metabolism studies
- Renal Transplantation Outcomes and Treatments
- Gallbladder and Bile Duct Disorders
- Clinical Nutrition and Gastroenterology
University of Alberta
2016-2025
University of Alberta Hospital
2017-2024
Alberta Hospital Edmonton
2017-2024
University of Pittsburgh Medical Center
2024
Mayo Clinic in Arizona
2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2011-2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2010-2023
Universitat de Barcelona
2012-2023
Alberta Health Services
2023
Ronald Reagan UCLA Medical Center
2023
This guidance provides a data-supported approach to risk stratification, diagnosis, and management of patients with cirrhosis portal hypertension (PH). A document is different from guideline. Guidelines are developed by multidisciplinary panel experts who rate the quality (level) evidence strength each recommendation using Grading Recommendations Assessment, Development, Evaluation system. in topic, statements, not recommendations, put forward help clinicians understand implement most recent...
Patients with cirrhosis in Child-Pugh class C or those B who have persistent bleeding at endoscopy are high risk for treatment failure and a poor prognosis, even if they undergone rescue transjugular intrahepatic portosystemic shunt (TIPS). This study evaluated the earlier use of TIPS such patients.We randomly assigned, within 24 hours after admission, total 63 patients acute variceal had been treated vasoactive drugs plus endoscopic therapy to polytetrafluoroethylene-covered stent 72...
In cirrhotic patients under pharmacologic treatment for portal hypertension, a reduction in hepatic venous pressure gradient (HVPG) of ≥20% baseline or to ≤12 mm Hg markedly reduces the risk variceal rebleeding. This study was aimed at evaluating whether these hemodynamic targets also prevent other complications hypertension and improve long-term survival. One hundred five included prospective trials prevention rebleeding were studied. Seventy-three had 2 separate HVPG measurements, therapy...
Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in chronic liver patients. In this study, we assessed the value of TE for prediction fibrosis stage cohort pediatric patients with nonalcoholic steatohepatitis. Furthermore, interobserver agreement was evaluated. performed 52 consecutive biopsy-proven steatohepatitis (32 males, 20 females, age 13.6 +/- 2.44 years). The area under receiver operating characteristic curves "any" (>or=1),...
Prognostic stratification of patients with alcoholic hepatitis (AH) may improve the clinical management and facilitate trials. We aimed at developing a scoring system capable providing prognostic AH.Patients biopsy-proven AH were prospectively included between 2000 2006. The biochemical, clinical, portal hemodynamic histological parameters evaluated. A Cox regression model was used for univariate multivariate analyses. predictive score built using variables obtained admission identified in...
In patients with compensated advanced chronic liver disease (cACLD), the presence of clinically significant portal hypertension (CSPH) and varices needing treatment (VNT) bears prognostic therapeutic implications. Our aim was to develop noninvasive tests-based risk prediction models provide a point-of-care assessment cACLD patients. We analyzed 518 from five centers in Europe/Canada paired tests (liver stiffness measurement [LSM] by transient elastography, platelet count, spleen diameter...
Lifelong immunosuppression increases morbidity and mortality in liver transplantation. Discontinuation of immunosuppressive drugs could lessen this burden, but the safety, applicability, clinical outcomes strategy need to be carefully defined. We enrolled 102 stable recipients at least 3 years after transplantation a single-arm multicenter withdrawal trial. Drugs were gradually discontinued over 6 9-month period. The primary endpoint was development operational tolerance, defined as...
Budd-Chiari syndrome (BCS) is a rare, life-threatening disease caused by obstruction of hepatic venous outflow. The aim the study was to assess long-term outcome and identify prognostic factors in BCS patients managed step-wise approach using anticoagulation, angioplasty/thrombolysis, transjugular intrahepatic portosystemic shunting (TIPS), orthotopic liver transplantation (OLT). We reviewed data on 157 previously included European Network for Vascular Disorders Liver, multicenter...