A5030494791- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Migraine and Headache Studies
- Stress Responses and Cortisol
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Pancreatitis Pathology and Treatment
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Fetal and Pediatric Neurological Disorders
- Neuropeptides and Animal Physiology
- Cerebrospinal fluid and hydrocephalus
- MRI in cancer diagnosis
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Iron oxide chemistry and applications
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- EEG and Brain-Computer Interfaces
- Adipose Tissue and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- Clay minerals and soil interactions
- Electroconvulsive Therapy Studies
Emory University
2025
Semmelweis University
2025
Amsterdam University Medical Centers
2024
University of Szeged
2014-2023
Békés Megyei Központi Kórház
2019
Central European Institute of Technology
2018
MTA-SZTE Research Group on Artificial Intelligence
2018
Eötvös Loránd University
2008-2015
Pázmány Péter Catholic University
2014
Weizmann Institute of Science
2005-2007
Background Recent studies on migraineurs and our own animal experiments have revealed that pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) has an important role in activation of the trigeminovascular system. The aim this study was to determine PACAP-38-like immunoreactivity (LI) plasma healthy subjects, parallel with calcitonin gene-related peptide (CGRP)-LI migraine patients ictal interictal periods. Methods A total 87 40 control volunteers were enrolled examination. Blood...
The cerebral cortex is composed of subregions whose functional specialization largely determined by their incoming and outgoing connections with each other. In the present study, we asked which cortical regions can exert greatest influence over other network as a whole. Previous research on this question has relied coarse anatomy (mapping large fiber pathways) or connectivity inter-regional statistical dependencies in ongoing activity). Here combined direct electrical stimulation recordings...
Activation of the trigeminal-autonomic reflex, involving trigeminal ganglion, superior salivatory nucleus and sphenopalatine ganglion (SPG) is crucial in pathophysiology cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) present both SPG (TG) its role migraine has been described, our aim was to determine plasma PACAP-38 levels different phases episodic CH (ECH). Peripheral cubital fossa blood samples were taken during ictal inter-bout periods male...
Migraine is one of the most severe primary headache disorders. The nature and associated symptoms during attack suggest underlying functional alterations in brain. In this study, we examined amplitude, resting state fMRI fluctuation migraineurs with without aura (MWA, MWoA respectively) healthy controls. Resting MRI images T1 high-resolution were acquired from all participants. For data analysis compared groups (MWA-Control, MWA-MWoA, MWoA-Control). networks identified by MELODIC. mean time...
Background: Formerly white matter abnormalities in a mixed group of migraine patients with and without aura were shown. Here, we aimed to explore alterations homogeneous migraineurs delineate possible relationships between changes clinical variables. Methods: Eighteen aura, 25 28 controls scanned on 1.5T MRI scanner. Diffusivity parameters the estimated compared patients' groups using whole-brain tract-based spatial statistics. Results: Decreased radial diffusivity (p < 0.036) was found...
We evaluated the effects of early maternal deprivation (MD; age 7–14 days) alone or in combination with unpredictable chronic stress (UCS; MDUN; 28–84 on anxiety and learning 90 days old adult rats. hypothesized that exposure to both stressors (MDUN) would be more detrimental than one neither. Unexpectedly, rats from MDUN group did not differ control animals, whereas MD animals exhibited impaired avoidance learning. next investigated effect juvenile-onset (30–90 versus adult-onset (60–90...
Brain atrophy is a key imaging hallmark of Alzheimer disease (AD). In this study, we carried out an integrative evaluation AD-related atrophy. Twelve patients with AD and 13 healthy controls were enrolled. We conducted cross-sectional analysis total brain tissue volumes SIENAX. Localized gray matter was identified optimized voxel-wise morphometry (FSL-VBM), subcortical evaluated by active shape model implemented in FMRIB's Integrated Registration Segmentation Toolkit. SIENAX demonstrated...
In the inflammatory process of multiple sclerosis (MS) several toxic waste products are generated. The clearance these might depend on glymphatic system; however, it's preserved function in MS is uncertain. Recently, it was suggested that this 'waste clearance' system can be examined by measuring diffusion along perivascular space (ALPS) index.
Abstract Background and purpose Cognitive impairment in multiple sclerosis (MS) is common associated with problems employment, driving ability, quality of life. Since cognitive at time diagnosis predictive disability progression, early assessment annual monitoring recommended. The Brief International Assessment Multiple Sclerosis (BICAMS) was introduced as a time‐efficient screening tool that can easily be applied standard clinical care. However, besides application, tests need to analysed...
Abstract Background Pediatric RSV-associated hospitalizations are well-described but mortality data limited. Methods RSV Hospitalization Surveillance Network (RSV-NET), a 12-state population-based surveillance system, captured laboratory-confirmed among catchment-area residents during October–April in 2018–19 and October–September 2021–22 (excluding May–June) 2022–23. Medical charts were reviewed for children who died in-hospital those ≤30 days post-discharge via matching case death...
Background: The sodium glucose cotransporter 2 (SGLT2) inhibitor may improve mitochondrial biogenesis and attenuate pulmonary vascular remodeling in arterial hypertension (PAH). We investigated the impact of empagliflozin PAH. Methods: Lung sections primary cell cultures isolated from microvascular endothelial cells (MVECs) were collected control subjects PAH patients. MVECs treated with biogenesis, metabolism, oxidative stress proliferation evaluated. Subsequently, was induced male female...
Abstract This study aims to investigate whether intranetwork dynamic functional connectivity and causal interactions of the salience network is altered in interictal term migraine. Thirty-two healthy controls, 37 migraineurs without aura, 20 with aura were recruited. Participants underwent a T1-weighted scan resting-state fMRI protocol inside 1.5T MR scanner. We obtained average spatial maps networks using group independent component analysis, which yielded subject-specific time series...
Next to the disseminated clinical symptoms, cognitive dysfunctions are common features of multiple sclerosis (MS). Over recent years several different MRI measures became available representing various pathology, but contribution and functions is not yet fully understood. In this multiparametric study we set out identify parameters that best predict disability in MS. High resolution T1 weighted structural high angular diffusion images were measured 53 patients with relapsing remitting MS...
Previous studies in primary headache disorders showed microstructural alterations the white matter as measured by diffusion imaging. However these investigations are not full agreement and some of those, especially cluster headache, restricted analysis to only a limited number parameters. Therefore, current study we examined microstructure patients.Diffusion weighted MRI images with 60 directions were acquired from thirteen patients sixteen age-matched healthy controls. Tract based spatial...
Background Previous functional and structural imaging studies have revealed that subcortical structures play a key role in pain processing. The recurring painful episodes might trigger maladaptive plasticity or alternatively degenerative processes be detected by MRI as changes size microstructure. In the current investigation, we aimed to identify macro- microstructural alterations of episodic cluster headache. Methods High-resolution T1-weighted diffusion-weighted images with 60 gradient...
Introduction: Brain structure and function were reported to be altered in migraine. Importantly our earlier results showed that white matter diffusion abnormalities resting state functional activity affected differently the two subtypes of disease, migraine with without aura. Resting fluctuation BOLD signal was recently. The question arising whether activity, is strongly coupled gray also perturbed differentially disease if so, it related microstructural alterations matter. Methods: fMRI, 60...
Lesion number and burden can predict the long-term outcome of multiple sclerosis, while localization lesions is also a good predictive marker disease progression. These biomarkers are used in studies clinical practice, but reproducibility lesion count not well-known.In total, five raters evaluated T2 hyperintense 140 patients with sclerosis six localizations: periventricular, juxtacortical, deep white matter, infratentorial, spinal cord, optic nerve. Black holes on T1-weighted images brain...
Objective: Cortical pathology, periventricular demyelination and lesion formation in multiple sclerosis (MS) are related (hypothesis 1). Factors the cerebrospinal fluid close to these compartments could possibly drive parallel processes. Alternatively, cortical atrophy be caused by remote axonal transection 2). Since MRI can differentiate between axon loss, we used this imaging modality investigate correlation pattern of diffusion parameter changes periventricular- deep white matter grey...
Abstract Previous studies have described the structure and function of insular cortex in terms spatially continuous gradients. Here we assess how spatial features resting state functional organization correspond to individual pain sensitivity. From a previous multicenter study, included 107 healthy participants, who underwent MRI scans, T1-weighted scans quantitative sensory testing on left forearm. Thermal mechanical thresholds were determined. Connectopic mapping, technique using...