A5085174047- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Cerebral Venous Sinus Thrombosis
- Advanced MRI Techniques and Applications
- Migraine and Headache Studies
- COVID-19 diagnosis using AI
- Vestibular and auditory disorders
- Hemispheric Asymmetry in Neuroscience
- Trigeminal Neuralgia and Treatments
- Spatial Neglect and Hemispheric Dysfunction
- Neural and Behavioral Psychology Studies
- Ophthalmology and Eye Disorders
- Neural dynamics and brain function
- Parkinson's Disease Mechanisms and Treatments
- Photoacoustic and Ultrasonic Imaging
- MRI in cancer diagnosis
- Glaucoma and retinal disorders
- Ultrasound and Hyperthermia Applications
- Facial Trauma and Fracture Management
- RNA regulation and disease
- Bone and Joint Diseases
- Cerebrospinal fluid and hydrocephalus
- COVID-19 Clinical Research Studies
Semmelweis University
2025
University of Szeged
2019-2023
In the inflammatory process of multiple sclerosis (MS) several toxic waste products are generated. The clearance these might depend on glymphatic system; however, it's preserved function in MS is uncertain. Recently, it was suggested that this 'waste clearance' system can be examined by measuring diffusion along perivascular space (ALPS) index.
Abstract This study aims to investigate whether intranetwork dynamic functional connectivity and causal interactions of the salience network is altered in interictal term migraine. Thirty-two healthy controls, 37 migraineurs without aura, 20 with aura were recruited. Participants underwent a T1-weighted scan resting-state fMRI protocol inside 1.5T MR scanner. We obtained average spatial maps networks using group independent component analysis, which yielded subject-specific time series...
Introduction: Brain structure and function were reported to be altered in migraine. Importantly our earlier results showed that white matter diffusion abnormalities resting state functional activity affected differently the two subtypes of disease, migraine with without aura. Resting fluctuation BOLD signal was recently. The question arising whether activity, is strongly coupled gray also perturbed differentially disease if so, it related microstructural alterations matter. Methods: fMRI, 60...
Lesion number and burden can predict the long-term outcome of multiple sclerosis, while localization lesions is also a good predictive marker disease progression. These biomarkers are used in studies clinical practice, but reproducibility lesion count not well-known.In total, five raters evaluated T2 hyperintense 140 patients with sclerosis six localizations: periventricular, juxtacortical, deep white matter, infratentorial, spinal cord, optic nerve. Black holes on T1-weighted images brain...
Abstract Previous studies have described the structure and function of insular cortex in terms spatially continuous gradients. Here we assess how spatial features resting state functional organization correspond to individual pain sensitivity. From a previous multicenter study, included 107 healthy participants, who underwent MRI scans, T1-weighted scans quantitative sensory testing on left forearm. Thermal mechanical thresholds were determined. Connectopic mapping, technique using...
Background: Multiple sclerosis may damage cognitive performance in several domains, including attention. Although attention network deficits were described during rest, studies that investigate their function task are scarce. Objective: To connectivity within and between task-related networks multiple a visual as of performance. Methods: A total 23 relapsing-remitting (RRMS) patients 29 healthy controls underwent task-functional magnetic resonance imaging (fMRI) scans using paradigm on 3T...
Abstract Transorbital sonography (TOS) could be a swift and convenient method to detect the atrophy of optic nerve, possibly providing marker that might reflect other quantitative structural markers multiple sclerosis (MS). Here we evaluate utility TOS as complementary tool for assessing nerve atrophy, investigate how TOS-derived measures correspond volumetric brain in MS. We recruited 25 healthy controls (HC) 45 patients with relapsing–remitting MS performed B-mode ultrasonographic...
Background: Hypointense lesions on T1-weighted images have important clinical relevance in multiple sclerosis patients. Traditionally, spin-echo (SE) sequences are used to assess these (termed black holes), but Fast Spoiled Gradient-Echo (FSPGR) provide an excellent alternative. Objective: To determine whether the contrast difference between T1 hypointense and surrounding normal white matter is similar two sequences, different lesion types could be identified, of different. Methods:...
Abstract Laterality patterns of resting state networks (RSN) change in various neuropsychiatric conditions. Multiple sclerosis (MS) causes neuro-cognitive symptoms involving dysfunctional large-scale brain networks. Yet, whether healthy laterality RSNs are maintained MS and altered explain disease has not been explicitly investigated. We analysed functional MRI diffusion tensor imaging data from 24 relapsing–remitting patients 25 participants. performed group-level independent component...
Eye movement deficits are frequently noted in multiple sclerosis during bedside clinical examination, but subtle dysfunction may remain undetected and might only be identified with advanced approaches. While classical neurology provides insight into the complex functional anatomy of oculomotor functions, little is known about structural background this MS. 34 clinically stable, treated relapsing-remitting MS patients mild disability healthy controls were included our study. Group difference...
ABSTRACT BACKGROUND AND PURPOSE Diffusion tensor imaging (DTI) is a promising approach to detect the underlying brain pathology. These alterations can be seen in several diseases such as multiple sclerosis. Tract‐based spatial statistics (TBSS) an easy use and robust way for analyzing diffusion data. The effect of acquisition parameters DTI on TBSS has not been evaluated, especially number encoding directions (NDED), which directly proportional with scan time. METHODS We analyzed large set...
Visual dysfunction is a recognized early symptom of Parkinson's disease (PD) that partly scales motor symptoms, yet its background heterogeneous. With additional deficits in visuospatial attention, the two systems are hard to disentangle and it not known whether impaired functional connectivity visual cortex translative nature or disrupted attentional modulation also contributes. In this study, we investigate during attention task patients with PD. total, 15 PD 16 age-matched healthy...
Cognitive decline is a prominent symptom of MS. Clear connection between cognitive status and white matter microstructural changes has not been unequivocally observed to date.To characterise the relationship microstructure performance partial least squares (PLS) approach was used.53 RR MS patients' T1 DTI images BICAMS subtests were used in our analysis. Standard FSL pipeline obtain diffusion parameters. A PLS applied reveal parameter patterns responsible for dysfunction.The first latent...
Lateralization of visuospatial attention in healthy people, known as pseudoneglect, results leftward bias during the Landmark or line bisection tasks. Cognitive dysfunctions patients with multiple sclerosis (MS) might affect attentional abilities well. In this study, we aimed to examine association between atrophy and lesion location extent lateralization MS.Visuospatial was measured 35 relapsing-remitting MS using task. To evaluate relation spatial gray matter atrophy, voxel-based...