A5100436075- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Nerve injury and regeneration
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Pluripotent Stem Cells Research
- Anesthesia and Neurotoxicity Research
- Hedgehog Signaling Pathway Studies
- Tryptophan and brain disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Meat and Animal Product Quality
- Genetics and Neurodevelopmental Disorders
- Bone Metabolism and Diseases
- Plant Pathogens and Fungal Diseases
- Intensive Care Unit Cognitive Disorders
- Nuclear Receptors and Signaling
- Ferroptosis and cancer prognosis
- Tea Polyphenols and Effects
- Neural Networks and Reservoir Computing
China Medical University
2020-2025
Hebei Medical University
2011-2024
Xinxiang Medical University
2024
First Affiliated Hospital of Xinxiang Medical University
2024
Hebei North University
2010-2023
Second Affiliated Hospital of Jilin University
2023
Hubei Provincial Hospital of Traditional Chinese Medicine
2023
Hubei University of Chinese Medicine
2023
St. Jude Children's Research Hospital
2016-2022
XinHua Hospital
2022
Stroke increases neurogenesis. The authors investigated whether neural stem cells or progenitor in the adult subventricular zone (SVZ) of rats contribute to stroke-induced increase After induction stroke rats, numbers immunoreactive doublecortin, a marker for immature neurons, increased ipsilateral SVZ and striatum. Infusion an antimitotic agent (cytosine-β-D-arabiofuranoside, Ara-C) onto cortex eliminated more than 98% actively proliferating doublecortin-positive However, rapidly...
In the adult rodent, stroke induces an increase in endogenous neural progenitor cell (NPC) proliferation subventricular zone (SVZ) and neuroblasts migrate towards ischemic boundary. We investigated role of stromal cell-derived factor 1α (SDF-1α) mediating NPC migration after stroke. found that cultured NPCs harvested from normal SVZ, when they were overlaid onto brain slices, exhibited significantly ( P > 0.01) increased (67.2 ± 25.2 μm) compared with on slices (29.5729.5 μm)....
Angiogenesis and neurogenesis are coupled processes. Using a coculture system, we tested the hypothesis that cerebral endothelial cells activated by ischemia enhance neural progenitor cell proliferation differentiation, while isolated from ischemic subventricular zone promote angiogenesis. Coculture of adult normal rat with stroke boundary substantially increased neuronal differentiation reduced astrocytic differentiation. Conditioned medium harvested promoted capillary tube formation cells....
Abstract Background Chemotherapeutic resistance is the main cause of clinical treatment failure and poor prognosis in triple-negative breast cancer (TNBC). There no research on chemotherapeutic TNBC from perspective circular RNAs (circRNAs). Methods TNBC-related circRNAs were identified based GSE101124 dataset. Quantitative reverse transcription PCR was used to detect expression level circWAC cells tissues. Then, vitro vivo functional experiments performed evaluate effects TNBC. Results...
We intracisternally transplanted subventricular zone (SVZ) cells labeled by ferromagnetic particles into stroked rats. Migration of was non-invasively tracked using magnetic resonance imaging (MRI). found that selectively migrated towards the ischemic parenchyma at a mean speed 65 +/- 14.6 microm/hr in living brain also measured histopathologically. Rats with SVZ exhibited significant improvement neurological function. Our data suggest intracisternal transplantation provides an avenue for...
Abstract Ischemic stroke stimulates neurogenesis in the adult rodent brain. The molecules that mediate stroke‐induced have not been fully investigated. Using a microarray containing 113 known genes associated with angiogenesis, we analyzed transcriptional profiles subventricular zone (SVZ) tissue and cultured neural progenitor cells isolated from SVZ of mice subjected to middle cerebral artery occlusion (MCAo). Among most robustly up‐regulated by MCAo were chemokine ligand 2 (CCL2) 10...
With the development of social population ageing, bone fracture has become a global public health problem due to its high morbidity, disability and mortality. Fracture healing is complex phenomenon involving coordinated participation immigration, differentiation proliferation inflammatory cells, angioblasts, fibroblasts, chondroblasts osteoblasts which synthesize release bioactive substances extracellular matrix components, Mortality caused by age-related fractures or osteoporosis steadily...
The intracellular mechanisms that regulate neurogenesis remain unclear. Using neurospheres isolated from the subventricular zone (SVZ) of adult rat, we investigated effect cyclic guanosine monophosphate (cGMP) and its signaling pathway on induction neurogenesis. Neurospheres expressed phosphodiesterase 5 (PDE5) treatment with Sildenafil, a specific inhibitor PDE5, significantly increased cGMP levels In addition, incubation Sildenafil phosphorylated Akt, which was associated an increase...
Abstract Circular RNA (circRNA) is a type of non-coding that widely expressed in mammals. It highly conserved and abundantly the brain. Here, we report regulatory role circRNA derived from pantothenate kinase 1 (Pank1) gene (circ-Pank1) Parkinson’s disease (PD). Circ-Pank1 substantia nigra (SN) PD model mice treated with rotenone MN9D cell dopaminergic neurons. The circ-Pank1 knockdown ameliorated neuron damage locomotor dysfunction after treatment rotenone. We found could adsorb miR-7a-5p...
Adult ependymal cells are postmitotic and highly differentiated. Radial glial neurogenic precursors. Here, we show that stroke acutely stimulated adult cell proliferation, dividing of the lateral ventricle had genotype, phenotype, morphology radial in rat. The majority exhibited symmetrical division about cleavage plane, a fiber was maintained throughout each stage mitosis. Increases parallel expansion neural progenitors subventricular zone (SVZ). Furthermore, after derived from SVZ...
Previous studies have examined the associations between individual foods or nutrients, but few considered dietary patterns associated with ovarian cancer (OC) survival. In a prospective cohort study, we association pre-diagnosis and post-diagnosis overall diet, including changes from to post-diagnosis, survival (OS) in 560 patients OC. Dietary intake was collected using valid 111-item food frequency questionnaire. Principal component analysis performed determine patterns. Cox proportional...
Ovarian cancer (OC) is the gynecologic with highest mortality. Circular RNAs (circRNAs) play a vital role in development and progression of cancer. This study aimed to explore potential circ_0015756 OC its molecular mechanism.The levels circ_0015756, microRNA-942-5p (miR-942-5p) Cullin 4B (CUL4B) were determined by quantitative real-time PCR (qRT-PCR) or Western blot assay. Cell proliferation, apoptosis, migration invasion assessed Counting Kit-8 (CCK-8), colony formation assay, flow...
Antioxidant response transcription factor nuclear erythroid-2-related 2 (Nrf2/Nfe2l2) is a neuroprotective agent in learning and memory impairment. This study provides new perspective to explore the regulatory mechanisms of Nrf2. Here, we found that Nrf2 regulated circular RNA circ-Vps41 increase hippocampal synaptic plasticity; bound Vps41 promoter activate gene promote expression circ-Vps41; positively correlated with Nrf2, plasticity, but negatively reactive oxygen species; promoted...
Proneuronal basic helix–loop–helix (bHLH) transcription factor, neurogenin 1 (Ngn1), regulates neuronal differentiation during development of the cerebral cortex. Akt mediates proneuronal bHLH protein function to promote differentiation. Here, we show that recombinant human erythropoietin (rhEPO) significantly increased activity and Ngn1 mRNA levels in neural progenitor cells derived from subventricular zone (SVZ) adult rat, which was coincident with increases cell proliferation,...
Inflammation is an important pathophysiological mechanism in diabetic nephropathy (DN). Tubular epithelial cell-myofibroblast transdifferentiation (TEMT), which can be induced by many cytokines, event DN. Oncostatin M (OSM), inflammatory cytokine, induce TEMT vitro. The suppressors of cytokine signaling (SOCS) proteins are negative-feedback regulators signaling. purpose this study was to investigate the role SOCS results demonstrated that overexpression ameliorated proteinuria, expression...