A5100378098- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Kruppel-like factors research
- Caveolin-1 and cellular processes
- RNA Research and Splicing
- FOXO transcription factor regulation
- Polyamine Metabolism and Applications
- Mitochondrial Function and Pathology
- Bone Metabolism and Diseases
- TGF-β signaling in diseases
- Curcumin's Biomedical Applications
- Ginseng Biological Effects and Applications
- RNA Interference and Gene Delivery
- Wnt/β-catenin signaling in development and cancer
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- Cancer-related gene regulation
- Bone health and osteoporosis research
- Pancreatic and Hepatic Oncology Research
- Autophagy in Disease and Therapy
- Bone health and treatments
First Affiliated Hospital of Soochow University
2017-2023
Soochow University
2017-2023
Hainan Medical University
2023
Nanjing University
2023
Guiyang Medical University
2023
Nanjing Medical University
2022
York University
2022
WuXi AppTec (China)
2021
China Pharmaceutical University
2020
Southwest Hospital
2019
Abstract Some types of circular RNA (circRNA) are aberrantly expressed in human diseases including hepatocellular carcinoma (HCC). However, its regulation mechanism and diagnostic roles largely unknown. Here, we identified that circRNA_104075 (circ_104075) was highly HCC tissues, cell lines serum. Mechanistically, HNF4a bound to the −1409 −1401 region circ_104075 promoter stimulate expression circ_104075. Moreover, acted as a ceRNA upregulate YAP by absorbing miR-582-3p. Interestingly, an N...
Rationale: Reactive oxygen species (ROS) burst from mitochondrial complex I is considered the critical cause of ischemia/reperfusion (I/R) injury. Ginsenoside Rb1 has been reported to protect heart against I/R injury; however, underlying mechanism remains unclear. This work aimed investigate if ginsenoside attenuates cardiac injury by inhibiting ROS production I. Methods: In in vivo experiments, mice were given and then subjected Mitochondrial levels determined using mitochondrial-targeted...
Abstract Background Chemotherapeutic resistance is the main cause of clinical treatment failure and poor prognosis in triple-negative breast cancer (TNBC). There no research on chemotherapeutic TNBC from perspective circular RNAs (circRNAs). Methods TNBC-related circRNAs were identified based GSE101124 dataset. Quantitative reverse transcription PCR was used to detect expression level circWAC cells tissues. Then, vitro vivo functional experiments performed evaluate effects TNBC. Results...
Abstract Background Circular RNAs (circRNAs) have recently been shown to play important roles in different tumors. However, their detailed and regulatory mechanisms pancreatic ductal adenocarcinoma (PDAC) are not well understood. This study aimed identify enriched circRNAs detect functions PDAC cells tissues. Methods circRNA-ASH2L (circ-ASH2L) was identified by circRNA microarray studies based on previous studies, further detected samples qRT-PCR. The of circ-ASH2L were transwell, EdU, cell...
Biological and clinical studies have indicated that aberrant expression of circMTO1 served as a crucial biomarker for the diagnosis prognosis hepatocellular carcinoma (HCC) patients well potential therapeutic target. However, detection circRNAs currently faces challenges such homologous linear RNA interference low-expression abundance certain circRNAs. Therefore, we developed triple amplification method based on catalytic hairpin assembly (CHA) activation by back-splice junction (BSJ),...
// Yan Chen 1, 2, * , Shai Huang Bo Wu 3, Jiankai Fang 2 Minsheng Zhu Li Sun 4 Lifeng Zhang 1 Yongsheng 5 Maomin Lingling Guo and Shouli Wang 6, 7 Department of Surgery, The First Affiliated Hospital Soochow University, Suzhou 215006, China Pathology, School Biology & Basic Medical Sciences, 215123, 3 People's Sihong County, 223900, Jiangsu Province, Laboratory Animal Research Center, University Medicine, Second 215004, 6 Molecular County Hospital, Key Tumor Microenvironment These authors...
Diabetes osteoporosis is a chronic complication of diabetes mellitus (DM) and associated with osteoclast formation enhanced bone resorption. Specnuezhenide (SPN) an active compound anti-inflammatory immunomodulatory properties. However, the roles SPN in diabetic remain unknown. In this study, primary marrow macrophages (BMMs) were pretreated stimulated receptor activator nuclear factor kappa B ligand (RANKL; 50 ng/mL) to induce osteoclastogenesis. The number osteoclasts was detected by...
Abstract Hepatocellular carcinoma (HCC) is a global health problem. Its incidence and mortality are increasing. Exploring novel therapeutic targets against HCC important urgent. We here explored the expression potential function of Gαi2 (G protein subunit alpha i2) in HCC. The Cancer Genome Atlas Liver Carcinoma (TCGA-LIHC) database shows that number transcripts tissues significantly higher than normal liver tissues. Moreover, overexpression correlates with poor prognosis patients. mRNA also...
We report herein the discovery of quinazolindiones as potent and selective tankyrase inhibitors. Elucidation structure-activity relationship lead compound 1g led to truncated analogues that have good potency in cells, pharmacokinetic (PK) properties, excellent selectivity. Compound 21 exhibited potencies cells proliferation studies, selectivity, vitro activities, an PK profile. also inhibited H292 xenograft tumor growth nude mice. The synthesis, biological, pharmacokinetic, vivo efficacy...
Circular RNAs (circRNAs) possess key functions in the pathogenesis of hepatocellular carcinoma (HCC). Nonetheless, actions individual circRNAs HCC remain undefined.circ_0031242, miR-944, and MAD2L1 expression were quantified by qRT-PCR. Transwell assay was utilized to examine cell invasion migration. Glucose consumption lactate production measured assess impact on glycolysis. The relationships among circ_0031242, MAD2L1, miR-944 examined via luciferase reporter assay.circ_0031242 notably...
Abstract The role of circular RNAs (ciRNAs; whose dysregulation causes various cancer types) in gastric (GC) remains largely unknown. Here, we investigated the expression a ciRNA, hsa_circ_0000026 (ciR-0026), GC tissues and deciphered molecular mechanism by which ciR-0026 suppresses cell proliferation. cells was analyzed using quantitative PCR. clinical significance changes SPSS.25 software. effects ciR-0026overexpression on phenotypes were determined colony formation, counting kit-8,...