A5071397507- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Problem and Project Based Learning
- Education and Critical Thinking Development
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Peroxisome Proliferator-Activated Receptors
- Alzheimer's disease research and treatments
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Plant-based Medicinal Research
- Sphingolipid Metabolism and Signaling
- Metabolism, Diabetes, and Cancer
- Traditional Chinese Medicine Studies
- Eicosanoids and Hypertension Pharmacology
- Diet and metabolism studies
- Innovative Teaching and Learning Methods
- Autophagy in Disease and Therapy
- Medicinal Plant Pharmacodynamics Research
- Mangiferin and Mango Extracts
- Traditional and Medicinal Uses of Annonaceae
- Insect Utilization and Effects
- Innovations in Medical Education
- Adipose Tissue and Metabolism
- Nephrotoxicity and Medicinal Plants
China Pharmaceutical University
2017-2025
Rationale: Reactive oxygen species (ROS) burst from mitochondrial complex I is considered the critical cause of ischemia/reperfusion (I/R) injury. Ginsenoside Rb1 has been reported to protect heart against I/R injury; however, underlying mechanism remains unclear. This work aimed investigate if ginsenoside attenuates cardiac injury by inhibiting ROS production I. Methods: In in vivo experiments, mice were given and then subjected Mitochondrial levels determined using mitochondrial-targeted...
Astrocytes activation in response to stroke results altered mitochondrial exchange with neurons. Ginsenoside Rb1is a major ginsenoside of Panax ginseng particularly known for its neuroprotective potential. This work aimed investigate if Rb1 could rescue neurons from ischemic insult via astrocyte inactivation and transfer. We prepared conditioned astrocytes-derived medium co-culture examined the role transfer astrocytes The potential was further confirmed vivo using mouse model brain...
Background: As new biomarkers of coronary artery diseases (CAD) emerge via metabolomics, the underlying functional mechanisms remain to be elucidated. Functional metabolomics aims translate metabolomics-derived disease mechanisms. Methods: A cohort 2324 patients who underwent angiography from 4 independent centers was studied. combination ultra–performance liquid chromatography and quadrupole time-of-flight mass spectrometry in negative ion mode used for untargeted analysis metabolites...
Abstract Disordered hepatic glucagon response contributes to hyperglycemia in diabetes. The regulators involved are less understood. This work aims investigate the roles of mitochondrial β-oxidation enzyme HADHA and its downstream ketone bodies response. Here we show that challenge impairs expression HADHA. Liver-specific overexpression reversed gluconeogenesis mice, while knockdown augmented Stable isotope tracing shows promotes body production via β-oxidation. β-hydroxybutyrate (BHB) but...
Dysbiotic gut microbiota has been identified as a primary mediator of inherent inflammation that underlies the pathogenesis obesity. Cordyceps comprises larval body and stroma sinensis (BerK.) Sacc. parasiting on Hepialidae larvae moths (H. pialusoberthur) with potent metabolic regulation functions. The underlying anti-obesity mechanisms, however, remain largely unknown. Here, we demonstrate water extract attenuates glucose lipid metabolism disorders its associated in high-fat diet (HFD)-fed...
Salvianolic acid B (Sal B), the main water-soluble compound in Salvia miltiorrhiza, is known to exhibit anti-inflammatory activity, however, underlying mechanism(s) not completely uncovered. In this study, Sal inhibited lipopolysaccharide (LPS)-induced M1 activation and promoted transformation of macrophages from M1- M2-type polarization. The altered lipid profiles LPS-induced RAW 264.7 were partly restored by treatment. At proteomic level, a total 5612 proteins identified 432 significantly...
Henoch-Schonlein purpura nephritis (HSPN) is a common glomerulonephritis secondary to (HSP) that affects systemic metabolism. Currently, there rarity of biomarkers predict the progression HSPN. This work sought screen metabolic markers HSPN via serum-urine matched metabolomics. A total 90 patients were enrolled, including 46 (+) with severe kidney damage (persistent proteinuria >0.3 g/day) and 44 (–) without obvious symptoms (proteinuria < 0.3 g/day). Untargeted metabolomics...
Abstract Objective This study aimed to comprehensively evaluate the effect of PBL on problem-solving, self-directed learning, and critical thinking ability pharmaceutical students through a randomized controlled trial (RCT) meta-analysis RCTs. Methods In 2021, 57 third-year pharmacy from China Pharmaceutical University were randomly divided into group lecture-based learning (LBL) group. Mean scores compared between two groups for communication skills, thinking, final exam grades. Students’...
Background: Long-term exposure to particular matter (PM), especially fine PM (< 2.5μm in the aerodynamic diameter, PM2.5), is associated with increased risk of cardiovascular disorders. This study aimed evaluate association between long-term PM2.5/PM10 and metabolites change plasma. Specifically, using metabolomics we sought identify biomarkers for vulnerable subgroup PM2.5 exposure.