A5115592495- Pain Mechanisms and Treatments
- Pain Management and Treatment
- Acupuncture Treatment Research Studies
- Myofascial pain diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Viral Infections and Vectors
- Research in Cotton Cultivation
- Gout, Hyperuricemia, Uric Acid
- Pain Management and Placebo Effect
- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Healthcare and Venom Research
- Vector-borne infectious diseases
- Gut microbiota and health
- Respiratory viral infections research
- Laser Applications in Dentistry and Medicine
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Metabolomics and Mass Spectrometry Studies
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Plant-based Medicinal Research
- Leptospirosis research and findings
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2019-2025
Shandong First Medical University
2025
China Pharmaceutical University
2025
Air Force General Hospital PLA
2025
Jilin Agricultural Science and Technology University
2025
Qinghai University
2025
All-Russian Institute of Light Alloys (Russia)
2025
Hebei Medical University
2023-2024
North China Electric Power University
2024
Zhejiang Chinese Medical University
2021-2024
Paclitaxel-induced peripheral neuropathy is a common adverse effect during paclitaxel treatment resulting in sensory abnormalities and neuropathic pain chemotherapy cancer survivors. Conventional therapies are usually ineffective possess effects. Here, we examined the effects of electroacupuncture (EA) on rat model paclitaxel-induced related mechanisms. EA robustly persistently alleviated hypersensitivities. Mechanistically, TLR4 (Toll-Like Receptor 4) downstream signaling MyD88 (Myeloid...
Background and Purpose Gout arthritis, which is provoked by monosodium urate (MSU) crystal accumulation in the joint periarticular tissues, induces severe pain affects quality of life patients. Eucalyptol (1,8‐cineol), principal component essential oils eucalyptus leaves, known to possess anti‐inflammatory analgesic properties. We aimed examine therapeutic effects eucalyptol on gout arthritis related mechanisms. Experimental Approach A mouse model was established via MSU injection into ankle...
Objective: Gout, induced by monosodium urate (MSU) crystal deposition in joint tissues, provokes severe pain and impacts life quality of patients. However, the mechanisms underlying gout are still incompletely understood. Methods: We established a mouse model intra-articularly injection MSU crystals into ankle wild type genetic knockout mice. RNA-Sequencing, vivo molecular imaging, Ca2+ reactive oxygen species (ROS) generation, neutrophil influx nocifensive behavioral assays, etc. were used....
Abstract Background Paclitaxel is a widely prescribed chemotherapy drug for treating solid tumors. However, paclitaxel-induced peripheral neuropathy (PIPN) common adverse effect during paclitaxel treatment, which results in sensory abnormalities and neuropathic pain among patients. Unfortunately, the mechanisms underlying PIPN still remain poorly understood. Long noncoding RNAs (lncRNAs) are novel promising targets chronic but their involvement remains unexplored. Methods We established rat...
Chronic pain, such as neuropathic causes anxiety and other negative emotions, which aggravates the pain sensation increases risk of chronic over time. Dopamine receptor D1 (DRD1) dopamine D2 (DRD2) in basolateral amygdala (BLA) have been implicated mediating anxiety-related behaviors, but their potential roles BLA pain-induced not examined. Electroacupuncture (EA) is commonly used to treat emotional disorders, it still unclear whether EA plays a role analgesia relief through DRD1 DRD2 BLA....
Abstract Background Complex regional pain syndrome type-I (CRPS-I) causes excruciating that affect patients’ life quality. However, the mechanisms underlying CRPS-I are incompletely understood, which hampers development of target specific therapeutics. Methods The mouse chronic post-ischemic (CPIP) model was established to mimic CRPS-I. qPCR, Western blot, immunostaining, behavioral assay and pharmacological methods were used study neuroinflammation in spinal cord dorsal horn (SCDH) CPIP...
Abstract Aims Epidemiological studies in patients with neuropathic pain have demonstrated a strong association between and psychiatric conditions such as anxiety. Preclinical clinical work has that electroacupuncture (EA) effectively alleviates anxiety‐like behaviors induced by chronic pain. In this study, potential neural circuitry underlying the therapeutic action of EA was investigated. Methods The effects stimulation on mechanical allodynia animal models spared nerve injury (SNI) were...
Modulation and suppression of the immune response host by nematode parasites have been reported extensively cysteine protease inhibitor (CPI or cystatin) is identified as one major immunomodulators. In present study, we cloned produced recombinant CPI protein from murine parasite Heligmosomoides polygyrus (rHp-CPI) investigated its immunomodulatory effects on dendritic cell (DC) function responses in mice. Bone-marrow-derived CD11c(+) DC (BMDC) that were exposed to rHp-CPI during...
We isolated Rickettsia japonica from a febrile patient in Lu'an City, China, 2013. Subsequently, we found an R. seroprevalence of 54.8% (494/902) the rural population Anhui Province and prevalence Haemaphysalis longicornis ticks 0.5% (5/935). its tick vector exist China.
Abstract Background Complex regional pain syndrome type-I (CRPS-I) is a progressive and devastating condition. The mechanisms of CRPS-I still remain poorly understood. We aim to explore expression profiles genes relevant neuroinflammation involved in CRPS-I. Methods rat chronic post-ischemic (CPIP) model that mimics human was established. RNA-sequencing (RNA-Seq), qPCR, Western blot, immunostaining, pharmacological studies were used for profiling gene changes ipsilateral spinal cord dorsal...
Abstract Background Gout results from disturbed uric acid metabolism, which causes urate crystal deposition in joints and surrounding tissues. pain management is largely limited to colchicine nonsteroidal anti-inflammatory drugs. Constant usage of these medications leads severe side effects. We previously showed electroacupuncture (EA) effective for relieving animal model gout arthritis. Here we continued study the mechanisms underlying how EA alleviates pain. Methods Monosodium was injected...
Excessive deposition of monosodium urate (MSU) crystal in the joint results gout arthritis, which triggers severe pain and affects life quality. Oxidative stress is a pivotal mechanism that contributes to etiology inflammation. Here we investigated whether activating Nrf2, plays important roles regulating endogenous antioxidant response, would attenuate arthritis via promoting signaling tissues. Gout model was established by intra-articular injection MSU (500 μg/ankle) into right ankle...
Cerebral malaria ( CM ) is a neurological syndrome often occurring in severe malaria. Although known as an immunopathology brain tissue mediated by excessive proinflammatory cytokines, the immunoregulatory mechanism poorly understood. Here, we investigated role of IL ‐10‐producing regulatory B reg) cells modulating development murine model P lasmodium berghei ANKA infection. We observed that blood‐stage . induced expansion reg C 57 BL /6 mice. Adoptive transfer ‐10 + to P. infected mice...
In the United States, poison ivy exposure is most common naturally occurring allergen to cause allergic contact dermatitis (ACD). The immune and pruritic mechanisms associated with ACD remain largely unexplored. Here, we compared skin whole transcriptomes itch mediator levels in mouse models induced by allergen, urushiol, synthetic oxazolone. urushiol model produced a Th2-biased response scratching behavior, resembling findings patients. Urushiol-challenged contained elevated of cytokine...
The gut microflora play a very important role in the life of animals. Although an increasing number studies have investigated microbiota birds recent years, there is lack research work on wild birds, especially carnivorous raptors, which are thought to be pathogen vectors. There also focused dynamics during development raptors. In this study, 16S rRNA gene amplicon high-throughput sequencing was used analyze community composition medium-sized raptor, Eurasian Kestrel ( Falco tinnunculus ),...
Plasticity in the microbial community composition and function can permit host to adapt ecological, environmental, physiological changes. Much of information on gut microbiota-host relationship date derives from studies laboratory model organisms, while little is known concerning wild animals their ecological relevance microbes. It also unclear how activity changes diet energy, nutritional requirements, utilization induced by dietary expansion invertebrates vertebrates. The great evening bat...
Neuropathic pain is a common cause of chronic and often accompanied by negative emotions, making it complex difficult to treat. However, the neural circuit mechanisms underlying these symptoms remain unclear. Herein, we present novel pathway associated with comorbid anxiety. Using chemogenetic methods, found that activation glutamatergic projections from rostral anterior cingulate cortex (rACC Glu ) ventrolateral periaqueductal gray (vlPAG) induced both hyperalgesia anxiety-like behaviors in...
Pain memory is commonly considered an underlying cause of chronic pain and also responsible for a range anxiety. Electroacupuncture (EA) has been shown to ameliorate memories exert anti-anxiety effects. Previous research indicated that GABAergic neurons and/or GABA receptors (GABARs) in the midcingulate cortex (MCC) have potential associations with However, there no known empirical specifically studied effects EA on system MCC. Here, we used cross-injection carrageenan establish rats model....