A5101941828- Hepatocellular Carcinoma Treatment and Prognosis
- Dialysis and Renal Disease Management
- Genetic factors in colorectal cancer
- Venous Thromboembolism Diagnosis and Management
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Systemic Lupus Erythematosus Research
- Colorectal Cancer Treatments and Studies
- Cardiovascular Syncope and Autonomic Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Diet and metabolism studies
- Cancer Mechanisms and Therapy
- NF-κB Signaling Pathways
- Nephrotoxicity and Medicinal Plants
- Radiomics and Machine Learning in Medical Imaging
- Neurological Disease Mechanisms and Treatments
- Berberine and alkaloids research
- Chronic Kidney Disease and Diabetes
- Clostridium difficile and Clostridium perfringens research
Union Hospital
2012-2025
Huazhong University of Science and Technology
2012-2025
Fudan University
2009-2024
Huashan Hospital
2009-2024
Karamay Central Hospital of Xinjiang
2024
Hebei North University
2017-2023
Shanxi University of Finance and Economics
2021
Jimo District Qingdao Hospital of Traditional Chinese Medicine
2020
University of Cincinnati
2018
Nanjing University
2013
Background Immune checkpoint inhibitors (ICIs) in combination with antiangiogenic drugs have shown promising outcomes the third-line and subsequent treatments of patients microsatellite stable metastatic colorectal cancer (MSS-mCRC). Radiotherapy (RT) may enhance antitumor effect immunotherapy. However, RT exposure on receiving ICIs targeted therapy remains unclear. This study aimed to investigate association between clinical responses fruquintinib (a highly selective tyrosine kinase...
This study aims to investigate the effects of glucose transport l (Glut1) gene on proliferation, differentiation, and apoptosis colorectal cancer (CRC) cells by regulating TGF-β/PI3K-AKT-mTOR signaling pathway. Immunohistochemistry was conducted detect positive Glut1 expression. Normal human CRC epithelial (CCD-18Co) cell line HCT116 were grouped into control, blank, negative control (NC), shGlut1-1 groups. RT-qPCR Western blotting performed expressions Glut1, TGF-β1, PI3K, AKT, PTEN, mTOR,...
Intradialytic hypotension (IDH) is a common complication of hemodialysis (HD), but there no consensus on its definition. In 2015, Flythe proposed definition IDH (Definition 1 in this study): nadir systolic blood pressure (SBP) <90 mmHg during for patients with pre-dialysis SBP <159 mmHg, and <100 ≥160 mmHg. This prospective observational cohort study investigated the association frequent based Definition clinical outcomes compared commonly used (nadir hemodialysis, 2). The incidence was...
The M(r) = 94,000 heavy chain of bovine factor Va contains 10 cysteine residues which are distributed in the 2 A domains make up this portion V molecule. A1 domain four cysteines while A2 six cysteines. locations disulfide bridges and free were analyzed using iodo[14C]acetamide-labeled digested with trypsin, plasmin, V-8 protease, cyanogen bromide. Following HPLC separation resulting peptides, identified by incorporation radioactivity disulfide-containing peptides detected an SBD-F...
Background: Hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) has poor prognosis. Sorafenib/Lenvatinib is recommended as the first-line therapy in these currently, unsatisfactory response and survival benefit reported. Radiotherapy (RT) increasingly utilized advanced HCC considered an alternative option for PVTT. Combined treatment of RT locoregional treatments such transarterial chemoembolization shows promising results. However, efficacy safety combined...
Intradialytic hypotension (IDH) is frequently accompanied by symptoms of nausea, dizziness, fatigue, muscle spasm, and arrhythmia, which can adversely impact the daily lives patients who undergo hemodialysis may lead to decreased quality life (QoL). This study employed KDQOL™-36 scale evaluate frequent IDH, based on definition determined predialysis blood pressure (BP) nadir systolic (SBP) thresholds, QoL patients.This a single center retrospective cohort involving 160 patients. We enrolled...
According to renal M type phospholipase A2 receptor (PLA2R) immunohistochemistry, idiopathic membranous nephropathy (IMN) could be categorized into PLA2R-associated and non-PLA2R-associated IMN. We conducted a retrospective, multicenter cohort study with 91 patients compare the effect of immunosuppressive therapy between IMN patients. A total biopsy-proven from Huashan hospital People's Hospital Wuxi in past 5 years were collected this study. positive PLA2R immunohistochemistry kidney...
Aldosterone has an important role in the progression of renal fibrosis. In present study, concentration aldosterone and klotho (KL) serum patients with chronic kidney disease (CKD) were analyzed. A negative correlation was observed between KL, suggesting that KL may serve a protective CKD. Subsequently, aldosterone‑induced CKD mouse model established using single nephrectomy subcutaneous osmotic pump 1% high‑salt drinking water. It demonstrated fibronectin 1 (Fn1) expression levels higher...
Unhealthy diet especially high-fat (HFD) is the major cause of hyperlipidemia leading to deterioration chronic kidney diseases (CKD) in patients. Trimethylamine N-oxide (TMAO) a gut-derived uremic toxin. Our previous clinical study demonstrated that elevation TMAO was positively correlated with CKD progression. Finasteride, competitive and specific inhibitor type II 5a-reductase, has been reported recently be able downregulate plasma level thus preventing onset atherosclerosis by our...
Objectives . To evaluate the value of whole volume apparent diffusion coefficient (ADC) histogram in distinguishing between benign and malignant breast lesions differentiating different molecular subtypes cancers to assess correlation ADC parameters Ki‐67 expression cancers. Methods The institutional review board approved this retrospective study. Between September 2016 February 2019, 189 patients with 84 105 underwent magnetic resonance imaging (MRI). Volumetric histograms were created by...
Patients with locally advanced rectal cancer (LARC) achieving a pathological complete response (pCR) to neoadjuvant treatment usually have good prognosis, but only accounted for less than 20%. We report case of 25-year-old male LARC treated FOLFOX chemotherapy, and experienced pCR. The next-generation sequencing analysis revealed the presence breast gene 2 (BRCA2) somatic mutation an increased mutational load without microsatellite instability (MSI). To our knowledge, this is first BRCA2...
Henoch-Schonlein purpura nephritis (HSPN) is a common glomerulonephritis secondary to (HSP) that affects systemic metabolism. Currently, there rarity of biomarkers predict the progression HSPN. This work sought screen metabolic markers HSPN via serum-urine matched metabolomics. A total 90 patients were enrolled, including 46 (+) with severe kidney damage (persistent proteinuria &gt;0.3 g/day) and 44 (–) without obvious symptoms (proteinuria &lt; 0.3 g/day). Untargeted metabolomics...
Objective To compare the clinical effects of three treatment methods including systemic thrombolysis(ST),catheter-directed thrombolysis(CDT),and AngioJet percutaneous mechanical thrombectomy(PMT)in acute lower extremity deep venous thrombosis(LEDVT). Methods The data 82 patients diagnosed with LEDVT in Department Vascular and Gland Surgery First Affiliated Hospital Hebei North University from January 2017 to December 2020 were collected.The assigned into a ST group(n=50),a CDT...
To optimize the dosing regimen in patients with severe renal impairment based on population pharmacokinetic (PPK)/pharmacodynamic analysis.The pharmacokinetics and safety of nemonoxacin was evaluated a single-dose, open-label, nonrandomized, parallel-group study after single oral dose 0.5-g capsule 10 healthy controls. Both blood urine samples were collected within 72 hours admission determined concentrations. A PPK model built using nonlinear mixed effects modelling. The probability target...
Survival benefit of liver cancer patients who undergo palliative radiotherapy varies from person to person. The present study aims identify indicators survival advanced receiving radiotherapy.One hundred and fifty-nine treated with for were retrospectively assessed. Of the 159 patients, 103 included prediction model construction in training phase, while other 56 analyzed external validation phase. In clinical characteristics evaluated by Kaplan-Meier curves log-rank test. Thereafter,...
Abstract: To evaluate the therapeutic effects of HELP system (heparin‐induced extracorporeal low‐density lipoprotein‐apolipoprotein(a)‐fibrinogen precipitation) in patients with acute ischemic stroke and probe into its possible mechanism, 10 were included this study received therapy addition to low molecular weight dextran, salvia miltiorrhiza aspirin. Matched gender, age, European Stroke Scale (ESS) fibrinogen, 20 cerebral infarction treated heparin chosen as controls during same period. We...
Objective: To investigate the effect of liraglutide on diabetic nephropathy in rats and its regulatory mechanism. Methods: The rat model was constructed with high-glucose-high-fat diet combination STZ, randomly divided into normal saline group group. were given sc 200 μg/kg liraglutide, 20 mg/kg twice a day for 4 weeks. control not treated any treatment. biochemical indexes such as body weight, 24-hour urine total protein quantification (UTP), fasting blood glucose (FPG), triglyceride (TG),...