A5035736887- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Biomedical Research and Pathophysiology
- Parathyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- Magnesium in Health and Disease
- MRI in cancer diagnosis
- Renal and related cancers
- Digestive system and related health
XinHua Hospital
2024
Fudan University
2018-2022
Huashan Hospital
2018-2022
<b><i>Background/Aims:</i></b> We aimed to determine if soluble α-klotho level was an indicator of chronic kidney disease (CKD) progression and whether interacted with aldosterone during the course further renal damage. <b><i>Methods:</i></b> 112 adults stages 1–5 CKD were enrolled into our cohort study. All patients followed up for 6 years (from January 2010 December 2015). Serum measured at baseline 1.5-years follow-up. The primary outcome...
Aldosterone has an important role in the progression of renal fibrosis. In present study, concentration aldosterone and klotho (KL) serum patients with chronic kidney disease (CKD) were analyzed. A negative correlation was observed between KL, suggesting that KL may serve a protective CKD. Subsequently, aldosterone‑induced CKD mouse model established using single nephrectomy subcutaneous osmotic pump 1% high‑salt drinking water. It demonstrated fibronectin 1 (Fn1) expression levels higher...
Tenascin-C (TNC), a non-structural extracellular matrix glycoprotein, is transiently expressed during development or after injury, playing an important role in injury and repair process. The potential of TNC the pathogenesis IgA nephropathy (IgAN) remains to be clarified.Immunohistochemistry staining for was conducted on paraffin-embedded slices from renal biopsies 107 IgAN patients, correlation analysis made between mesangial expression clinic-pathological parameters. In situ hybridization...
We aimed to explore the associated factors of endothelial injury in chronic kidney disease (CKD) and relationship between dysfunction CKD prognosis.A prospective observational cohort study.77 adults with stages 1-5 were enrolled January 2010 December followed up until 2015.Serum asymmetric dimethylarginine (ADMA) level at baseline, α-klotho, sodium-phosphorus synergistic transporter, dimethylarginine-dimethylamine hydrolase expression biopsy samples.Initiation replacement therapy...