A5061507619- Renal Diseases and Glomerulopathies
- Hormonal Regulation and Hypertension
- Autoimmune Bullous Skin Diseases
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ion Transport and Channel Regulation
- Parathyroid Disorders and Treatments
- Biomedical Research and Pathophysiology
- Electrolyte and hormonal disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Diabetes Treatment and Management
- Kruppel-like factors research
- Platelet Disorders and Treatments
- Helicobacter pylori-related gastroenterology studies
- Microtubule and mitosis dynamics
- Abdominal vascular conditions and treatments
- Potassium and Related Disorders
- Urticaria and Related Conditions
- Muscle and Compartmental Disorders
- Healthcare cost, quality, practices
- Cell Adhesion Molecules Research
- Celiac Disease Research and Management
Huashan Hospital
2009-2024
Fudan University
2009-2024
General Hospital of Shenyang Military Region
2023
Command Hospital
2022
University of Alabama at Birmingham
2015-2021
University of Maryland, Baltimore
1997
Enteropathogenic Escherichia coli strains are able to signal host cells, cause dramatic cytoskeletal rearrangements, and adhere intimately the cell surface in a process known as attaching effacing effect. A pathogenicity island of 35 kb locus enterocyte effacement (LEE) is necessary sufficient for this The LEE encodes an outer membrane adhesin called intimin, type III secretion apparatus, EspA EspB secreted proteins. DNA sequence region between espA espB revealed new gene, espD. product espD...
IgA nephropathy, a frequent cause of end-stage renal disease, is an autoimmune disease wherein immune complexes consisting IgA1 with galactose-deficient O-glycans (autoantigen) and anti-glycan autoantibodies deposit in glomeruli induce injury. Multiple genetic loci associated risk have been identified. The prevalence alleles varies geographically, highest eastern Asia northern Europe, fewer other parts Europe North America, the least Africa. nephropathy diagnosed from pathological assessment...
Trimethylamine N-oxide (TMAO) leads to the development of cardiovascular and chronic kidney diseases, but there are currently no potent drugs that inhibit production or toxicity TMAO.In this study, high-fat diet-fed ApoE-/-mice were treated with finasteride, ranitidine, andrioe.Subsequently, distribution quantity gut microbiota in faeces mice each group analysed using 16S rRNA sequencing V3+V4 regions.Pathological examination confirmed both ranitidine finasteride reduced atherosclerosis...
Background Low circulating vitamin D levels have been suggested to potentially contribute acute complications in critically ill patients. However, patients with kidney injury (AKI), whether deficiency occurs and is a potential contributor worse early outcomes at the time of AKI diagnosis remains unclear. Methodology/Principal Findings Two hundred were enrolled our study. Healthy subjects without served as controls. Serum concentrations measured three groups. The followed up for 90 days...
Klotho expression abnormalities induces kidney injury and chronic disease, however, the underlying mechanism remains unclear.Here, +/-mice wild-type mice were treated with low-dose bovine serum albumin (BSA).Pathological examination demonstrated that area of glomerular collagen deposition fibrosis in BSA-Kl -/+ was significantly larger than BSA-WT mice.The levels superoxide dismutase, malondialdehyde, creatinine, urea increased.Sequencing gut microbiota 16S rRNA v3-v4 region indicated showed...
<b><i>Background/Aims:</i></b> We aimed to determine if soluble α-klotho level was an indicator of chronic kidney disease (CKD) progression and whether interacted with aldosterone during the course further renal damage. <b><i>Methods:</i></b> 112 adults stages 1–5 CKD were enrolled into our cohort study. All patients followed up for 6 years (from January 2010 December 2015). Serum measured at baseline 1.5-years follow-up. The primary outcome...
The development and formation of mammalian blood vessels are closely related to the regulation signal transduction pathways.Klotho/AMPK YAP/TAZ signaling pathways angiogenesis, but internal relationship between them is not clear.In this study, we found that Klotho heterozygous deletion mice (Klotho +/-mice) had obvious thickening renal vascular wall, enlargement volume, significant proliferation pricking endothelial cells.Western blot showed expression levels total YAP protein, p-YAP protein...
Aldosterone has an important role in the progression of renal fibrosis. In present study, concentration aldosterone and klotho (KL) serum patients with chronic kidney disease (CKD) were analyzed. A negative correlation was observed between KL, suggesting that KL may serve a protective CKD. Subsequently, aldosterone‑induced CKD mouse model established using single nephrectomy subcutaneous osmotic pump 1% high‑salt drinking water. It demonstrated fibronectin 1 (Fn1) expression levels higher...
It is crucial to utilize combination therapy for immunoglobulin A nephropathy (IgAN) patients reduce proteinuria and maintain stable kidney function. We demonstrate the safety efficacy of low-dose spironolactone in management IgAN patients.
During the run-in phase of TESTING study, approximately half patients with IgA nephropathy (IgAN) were excluded due to proteinuria below 1 g/24 h after intensive supportive therapy. The long-term prognosis these needs further investigation.
<i>Background:</i> Aldosterone plays an important role in fibrosis. Recent studies showed that Na<sup>+</sup>-H<sup>+</sup> exchanger isoform 1 (NHE1) is involved mineralocorticoid-induced organ In this study, we examined the of NHE1 aldosterone-induced fibronectin accumulation rat mesangial cells and signaling pathway involved. <i>Methods:</i> We detected expression mineralocorticoid receptor 11β-hydroxysteroid dehydrogenase 2 glomeruli by...
Rationale: Renal complications in ankylosing spondylitis (AS) were rarely observed, and proteinuria associated with AS can be seen often due to amyloidosis this kind of complications, while membranous nephropathy (MN) is seldom considered. This article reports a case coexistence MN, provide the exact relationship these 2 entities recognized some causes renal involvement AS. Patient concerns: A 44-year-old female presented pain left leg for 4 years pedal edema weeks. Diagnoses: was diagnosed...
Henoch-Schonlein purpura nephritis (HSPN) is a common glomerulonephritis secondary to (HSP) that affects systemic metabolism. Currently, there rarity of biomarkers predict the progression HSPN. This work sought screen metabolic markers HSPN via serum-urine matched metabolomics. A total 90 patients were enrolled, including 46 (+) with severe kidney damage (persistent proteinuria &gt;0.3 g/day) and 44 (–) without obvious symptoms (proteinuria &lt; 0.3 g/day). Untargeted metabolomics...
Patients with IgA vasculitis (IgAV), an immune complex-mediated disease, may exhibit kidney involvement—IgAV nephritis (IgAVN). The kidney-biopsy histopathologic features of IgAVN are similar to those nephropathy, but little is known about disease severity based on the interval between purpura onset and diagnostic biopsy. We assessed histopathology clinical laboratory data in a cohort adult patients (n = 110). cases were grouped biopsy: Group 1 (G1, <1 month, n 14), 2 (G2, 1–6 months,...
Tenascin-C (TNC), a non-structural extracellular matrix glycoprotein, is transiently expressed during development or after injury, playing an important role in injury and repair process. The potential of TNC the pathogenesis IgA nephropathy (IgAN) remains to be clarified.Immunohistochemistry staining for was conducted on paraffin-embedded slices from renal biopsies 107 IgAN patients, correlation analysis made between mesangial expression clinic-pathological parameters. In situ hybridization...
Inflammatory demyelinating neuropathies such as Guillain-Barré syndrome (GBS), chronic inflammatory polyneuropathy (CIDP), and focal segmental glomerulosclerosis (FSGS) are autoimmune disorders that may have a common pathogenesis. Here, we describe 2 unique cases of FSGS, 1 with GBS the other CIPD. We believe reviewing these multisystemic diseases will help in better understanding FSGS pathogenesis.The 1st patient, 66-year-old woman, complained tingling numbness limbs within days, she...