A5042835753- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Fatty Acid Research and Health
- Folate and B Vitamins Research
- Adipose Tissue and Metabolism
- Dietary Effects on Health
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Prostate Cancer Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Phytoestrogen effects and research
- Lipid metabolism and biosynthesis
- Trace Elements in Health
- Hormonal and reproductive studies
- Advanced biosensing and bioanalysis techniques
- Cancer survivorship and care
- Pregnancy and preeclampsia studies
- Cervical Cancer and HPV Research
- Salivary Gland Disorders and Functions
- Birth, Development, and Health
- Endometrial and Cervical Cancer Treatments
- Epigenetics and DNA Methylation
- Molecular Sensors and Ion Detection
University of Alabama
2012-2024
University of Alabama at Birmingham
2007-2021
University of Michigan
2012
University of Maryland, Baltimore
2012
Cornell University
2012
Case Western Reserve University
2012
Enterolactone and enterodiol, mammalian lignans derived from dietary sources such as flaxseed, sesame seeds, kale, broccoli, apricots, may impede tumor proliferation by inhibiting activation of nuclear factor kappa B (NFκB) vascular endothelial growth (VEGF). We examined the associations between urinary enterolactone enterodiol with prostatic expression NFκB, VEGF, Ki67 among 147 patients prostate cancer who participated in a presurgical trial flaxseed supplementation (30 g/day) for ∼30...
Obesity is associated with aggressive prostate cancer. To explore whether weight loss favourably affects tumour biology and other outcomes, we undertook a presurgical trial among overweight obese men This single-blinded, two-arm randomised controlled explored outcomes of intervention (WLI) that promoted ∼1 kg per week via caloric restriction increased physical activity (PA). Forty overweight/obese clinically confirmed cancer were to the WLI presurgery or control arm; changes in weight, body...
Obesity adversely impacts overall and cancer‐specific survival among breast cancer patients. Preclinical studies demonstrate negative energy balance inhibits progression; however, feasibility effects in patients are unknown. A two‐arm, single‐blinded, randomized controlled weight‐loss trial was undertaken presurgery 32 overweight/obese, Stage 0–II The attention control arm (AC) received basic nutritional counseling upper‐body progressive resistance training whereas the weight loss...
Obesity is associated with tumor aggressiveness and disease-specific mortality for more than 15 defined malignancies, including prostate cancer. Preclinical studies suggest that weight loss from caloric restriction increased physical activity may suppress hormonal, energy-sensing, inflammatory factors drive neoplastic progression; however, exact mechanisms are yet to be determined, experiments in humans limited.We conducted a randomized controlled trial among 40 overweight or obese,...
Small-molecule fluorescent sensors are versatile agents for detecting mobile zinc in biology. Capitalizing on the abundance of validated probes, we devised a strategy repurposing existing intensity-based quantitative applications. Using solid-phase peptide synthesis, conjugated zinc-sensitive Zinpyr-1 derivative and zinc-insensitive 7-hydroxycoumarin onto opposite ends rigid P9K scaffold to create HcZ9, ratiometric probe zinc. A plate reader-based assay using HcZ9 was developed, accuracy...
Previous observational studies have reported associations between prostate cancer and alpha-linolenic acid (ALA). However, few investigations been able to study this relationship prospectively in well-controlled settings. Moreover, no determined whether single nucleotide polymorphisms (SNPs) that influence ALA metabolism are associated with common cancer. The purpose of was explore prostatic levels ALA, SNPs cancer-specific biomarkers samples collected from a previous randomized clinical...
Lower serum concentrations of sex‐hormone binding globulin (SHBG) are associated with increased risk for several obesity‐related diseases in women including hormone‐sensitive cancers, type 2 diabetes, metabolic syndrome, and cardiovascular disease. Previous investigations have reported that body composition, specifically central obesity, and/or higher insulin key factors lower SHBG overweight obese women; however, these studies were limited by their cross‐sectional design. We hypothesized...
Obesity is a known risk factor for postmenopausal breast cancer and associated with poorer prognosis premenopausal patients; however, the aetiological mechanisms are unknown. Preclinical studies support weight loss via caloric restriction increased physical activity as possible control strategy, though few clinical have been conducted. We undertook feasibility trial among women recently diagnosed stage 0-II hypothesising that presurgical would be feasible, safe result in favourable changes...
The purpose of this study was to evaluate whether mandatory fortification grain products with folic acid in the USA is associated changes global DNA methylation cells involved cervical carcinogenesis. Archived specimens i
Patients with IgA vasculitis (IgAV), an immune complex-mediated disease, may exhibit kidney involvement—IgAV nephritis (IgAVN). The kidney-biopsy histopathologic features of IgAVN are similar to those nephropathy, but little is known about disease severity based on the interval between purpura onset and diagnostic biopsy. We assessed histopathology clinical laboratory data in a cohort adult patients (n = 110). cases were grouped biopsy: Group 1 (G1, <1 month, n 14), 2 (G2, 1–6 months,...
Purpose: Obesity is associated with risk and prognosis of endometrial cancer (EC), the mammalian target rapamycin complex 1 (mTORC1) pathway may play an instrumental role. We sought to explore associations between cellular proliferation, Akt, 4E binding protein-1 (4E-BP1) (a downstream mTORC1), in obese nonobese women without EC. Methods: Archival tissue-specimens from biopsies were grouped into two broad categories based on observed disease behavior similarities tissue staining patterns:...
Abstract We investigated whether serum from normal weight women is less mitogenic and more apoptotic than sera the same in overweight state. Sera premenopausal women, age (mean ± SEE) 34.6 0.53 years, who were randomized to caloric restriction (CR) (n = 13), CR + aerobic exercise (AE) 14), or resistance training (RT) 20) used culture endometrial cancer cells. Phases of cell cycle determined, proliferating nuclear antigen (PCNA) positivity was assess proliferation apoptosis assessed by...
Objectives: Hypertension during pregnancy is the leading cause of pregnancy-related mortality in United States to long-term cardiovascular perturbations for both offspring and mothers. Although dietary nitrate known decrease blood pressure (BP), it unknown whether will augment effects hypertension medication therapies. This study evaluated alone or with labetalol on BP echocardiograph measures spontaneously hypertensive rat (SHR) dams their offspring. Methods: Twenty-week-old female SHR were...