A5035967340- Cancer survivorship and care
- Nutrition and Health in Aging
- Health and Medical Research Impacts
- Childhood Cancer Survivors' Quality of Life
- Cancer, Lipids, and Metabolism
- Nutritional Studies and Diet
- Cancer Risks and Factors
- Health Sciences Research and Education
- Phytoestrogen effects and research
- Physical Activity and Health
- Innovations in Medical Education
- Ethics in Clinical Research
- Tea Polyphenols and Effects
- Health Systems, Economic Evaluations, Quality of Life
- Advances in Oncology and Radiotherapy
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Fatty Acid Research and Health
- Cancer-related cognitive impairment studies
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmaceutical Economics and Policy
- Lymphatic System and Diseases
- Meta-analysis and systematic reviews
- Cancer, Stress, Anesthesia, and Immune Response
- Dietary Effects on Health
Duke University
2013-2024
Merck (Singapore)
2024
Johnson & Johnson (Israel)
2024
Astellas Pharma (China)
2024
Memorial Sloan Kettering Cancer Center
2024
Innovative Clinical Research
2024
Augusta University
2019
Columbia University
2019
Duke Medical Center
2006-2018
Abington Memorial Hospital
2013
<h3>Context</h3>Five-year survival rates for early stage colorectal, breast, and prostate cancer currently exceed 90% are increasing. Cancer survivors at greater risk second malignancies, other comorbidities, accelerated functional decline. Lifestyle interventions may provide benefit, but it is unknown whether long-term can modify their lifestyle behaviors sufficiently to improve status.<h3>Objective</h3>To determine a telephone counseling mailed print material–based diet exercise...
Cancer survivors are at increased risk for cardiovascular disease, diabetes, osteoporosis, and second primary tumors. Healthful lifestyle practices may improve the health well-being of survivors. The FRESH START trial tested efficacy sequentially tailored versus standardized mailed materials on improving cancer survivors' diet exercise behaviors.Five hundred forty-three individuals with newly diagnosed locoregional breast or prostate were recruited from 39 states two provinces within North...
Declines in physical functioning (PF) among elderly cancer patients threaten quality of life and the ability to maintain independence. Adherence healthy lifestyle behaviors may prevent functional decline.Project Leading Way Exercise Diet (LEAD), an intervention development study Pepper Older Americans Independence Center, aimed determine whether breast prostate survivors (age 65+ years) assigned a 6-month home-based diet exercise experienced improvements PF when compared with attention...
Abstract BACKGROUND: Older cancer survivors are at increased risk for secondary cancers, cardiovascular disease, obesity, and functional decline and, thus, may benefit from health‐related interventions. However, to the authors' knowledge, little is known regarding health behaviors of older associations those with quality‐of‐life outcomes, especially during long‐term post‐treatment period. METHODS: In total, 753 (aged ≥65 years) (≥5 years postdiagnosis) breast, prostate, colorectal completed...
Abstract Background: Prostate cancer affects one of six men during their lifetime. Dietary factors are postulated to influence the development and progression prostate cancer. Low-fat diets flaxseed supplementation may offer potentially protective strategies. Methods: We undertook a multisite, randomized controlled trial test effects low-fat and/or flaxseed-supplemented on biology other biomarkers. patients (n = 161) scheduled at least 21 days before prostatectomy were randomly assigned...
Diet and exercise interventions have been tested in cancer survivors as a means to reduce late effects comorbidity, but few assessed adherence health outcomes long term.
While moderate- to vigorous-intensity physical activities (MVPA) confer the greatest health benefits, evidence suggests that light-intensity are also beneficial, particularly for older adults and individuals with moderate severe comorbidities.To examine cross-sectional longitudinal associations between activity function in cancer survivors at increased risk age- treatment-related comorbidities, including accelerated functional decline.The analysis included data from 641 breast, prostate,...
The clinical and translational research enterprise is recognized by many as the "evidence generation system." While there have been several calls to revolutionize this more effectively deliver fruits of biomedical science patients society, significant issues across workforce are pervasive. Perhaps most visible sign widening gap between supply demand for competent staff. Underpinning this, a perfect storm complex issues. Now reaching crisis point, problem far bigger than staffing issue...
Purpose/Objectives: To determine childhood cancer survivors' barriers to increasing exercise and consuming less fat more fruits vegetables, whole grains, calcium-rich foods.
BACKGROUND Few studies to date have used the cancer diagnosis as a teachable moment promote healthy behavior changes in survivors of and their family members. Given role obesity primary tertiary prevention breast cancer, authors explored feasibility mother‐daughter weight loss intervention. METHODS A randomized controlled trial mailed intervention was undertaken among 68 dyads (n = 136), each comprised survivor (AJCC stage 0‐III) her adult biological daughter. All women had body mass indices...
Abstract Background This study examined whether changes in self‐efficacy explain the effects of a mailed print intervention on long‐term dietary practices breast and prostate cancer survivors. The relationship between change physical activity (PA) also was examined. Methods Breast survivors ( N = 543) from 39 US states two Canadian provinces participated FRESH START trial. Participants were randomly assigned to receive 10‐month program materials diet PA available public domain or tailored...
Purpose The primary study aim was to evaluate associations of estimated weekly minutes moderate-to-vigorous-intensity exercise from self-reports the telephone-administered 7-Day Physical Activity Recall (7-Day PAR) with data captured by RT3 triaxial accelerometer. Methods This investigation undertaken as part FRESH START study, a randomized clinical trial that tested an iteratively tailored diet and mailed print intervention among newly diagnosed breast prostate cancer survivors. A...
Abstract Objective : Cure rates for cancer are increasing, especially breast, prostate, and colorectal cancer. Despite positive trends in survivorship, a diagnosis can trigger accelerated functional decline that threaten independence, reduce quality‐of‐life increase healthcare costs, among the elderly who comprise majority of survivors. Lifestyle interventions may hold promise reorienting older survivors, but few studies have been conducted. Methods We describe design methods randomized...
Enterolactone and enterodiol, mammalian lignans derived from dietary sources such as flaxseed, sesame seeds, kale, broccoli, apricots, may impede tumor proliferation by inhibiting activation of nuclear factor kappa B (NFκB) vascular endothelial growth (VEGF). We examined the associations between urinary enterolactone enterodiol with prostatic expression NFκB, VEGF, Ki67 among 147 patients prostate cancer who participated in a presurgical trial flaxseed supplementation (30 g/day) for ∼30...
BACKGROUND The health benefits of diet and exercise interventions for cancer survivors are well documented. However, little is known regarding demographic medical predictors survivors' willingness to participate in intervention trials, study enrollment, adherence, completion. To assist interpreting the generalizability trial findings improve design future this examined these process measures. METHODS An integrative data analysis was performed on from 3 largest home‐based trials (n = 23,841)....
The purpose of this study was to identify parents' self-reported stressors as they experience their baby's course in the neonatal intensive care unit (NICU). Miles, Funk & Carlson (1993) Parental Stressor Scale: Neonatal Intensive Care Unit used survey 119 parents infants, born at 24 weeks full term, 28-bed level 3 NICU a mid-Atlantic, Magnet-designated acute hospital with 665 licensed beds. newly developed Grosik, Snyder, Cleary and Tidwell External Stressors Stress Reduction Scale (2006),...
Abstract The potential for physicians, clinicians, and health professionals to contribute the advancement of medical therapies through clinical research is significant. Yet, a lack exposure to, or practical training in, conduct can inhibit profession trainees from considering careers, thus perpetuating already limited influx new talent. To enhance sustainability career pathways into all trainees, including those traditionally underrepresented communities, must experience early concepts...
Abstract Background: Clinical research professionals (CRPs) are essential members of teams serving in multiple job roles. However, recent turnover rates have reached crisis proportions, negatively impacting clinical trial metrics. Gaining an understanding satisfaction factors among CRPs working at academic medical centers (AMCs) can provide insights into retention efforts. Materials/Methods: A survey instrument was developed to measure key related CRP and retention. The included 47 rating...
Objectives/Goals: Clinical research professional (CRP) managers often struggle to onboard effectively in the rapid timelines necessary. We developed a competency-based, standardized, onboarding program using 3-factor adult learning approach and designed be easily adaptable, broadly shared, readily implemented across variety of environments. Methods/Study Population: The Duke competency-based for CRPs was through an iterative process with input from community members. Initially, 97 courses...
Objectives/Goals: The primary objectives of this project were to create a user-friendly website that • Shares details ongoing studies in an easily searchable and filterable format. Provides lay summaries study results. Highlights our volunteer registry. Offers platform for community engagement feedback on research interests. Methods/Study Population: website, developed using DRUPAL 10 launched June 2024, was created with input from faculty, staff, participants, partners. It targets potential...