A5084134700- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Asymmetric Hydrogenation and Catalysis
- Cancer-related gene regulation
- Kruppel-like factors research
- Synthetic Organic Chemistry Methods
- Catalytic C–H Functionalization Methods
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Pharmacological Effects of Natural Compounds
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Ginseng Biological Effects and Applications
- Neuroblastoma Research and Treatments
- Gut microbiota and health
- Microgrid Control and Optimization
- 3D Shape Modeling and Analysis
- Computational Geometry and Mesh Generation
- Computer Graphics and Visualization Techniques
- Advanced Neuroimaging Techniques and Applications
- Chemical Synthesis and Analysis
- Photovoltaic System Optimization Techniques
- Retinal and Macular Surgery
- Oxidative Organic Chemistry Reactions
XinHua Hospital
2020-2024
Shanghai Jiao Tong University
2016-2023
Renji Hospital
2023
Weatherford College
2023
University of Illinois Chicago
2021-2023
Resonance Research (United States)
2023
Shandong First Medical University
2019-2023
Qinghai University for Nationalities
2018-2019
Lanzhou University
2016-2018
Dalian Medical University
2016-2017
Reseda odorata L. has long been used in traditional Asian medicine for the treatment of diseases associated with oxidative injury and acute inflammation, such as endotoxemia, lung injury, myocardial infarction hepatitis. Luteolin, main component L., which is also widely found many natural herbs vegetables, shown to induce heme oxygenase-1 (HO-1) expression exert anti-inflammatory antioxidant effects. In this study, we aimed examine effects luteolin on mice severe pancreatitis (SAP), explore...
A catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles has been reported under mild conditions.
Autophagy flux deficiency is closely related to the development of hepatic steatosis. Transcription factor E3 (TFE3) reported be a crucial gene that regulates autophagy and lysosome function. Therefore, we investigated role TFE3 in cell model We constructed L02 hepatocyte lines stably over-expressed or knocked down expression TFE3. Subsequently, effects on hepatocellular lipid metabolism were determined by assay, oil red O (ORO) staining, immunofluorescence mitochondrial β-oxidation...
By employing a simple in situ generated magnesium catalyst, direct asymmetric reaction between hemiacetals and phosphorus ylides was achieved through tandem Wittig-oxa-Michael sequence. Enantioenriched chromans, isochromans, tetrahydropyrans were obtained good chemical yields, (-)-erythrococcamide B synthesized enantioenriched form. The byproduct triphenylphosphine oxide identified as necessary additive for this process.
Abstract A Mg II ‐mediated catalytic asymmetric dearomatization (CADA) reaction of β‐naphthols has been developed. The proceeds under ambient temperature and give a series chiral trisubstituted olefins with good chemoselectivities, Z / E ratios, excellent enantioselectivities. fluorinated β‐naphthol was designed to generate organofluorine skeletons through the current CADA reaction. Moreover, an interesting tandem cyclization observed in following transformation process undiscovered...
The first α-sp<sup>2</sup>-carbon of carbonyl compounds attacked catalytic desymmetrization reaction aziridines is disclosed by employing a simple <italic>in situ</italic> generated magnesium catalyst.
A highly enantioselective ring-opening alkylation reaction between 3-aryl-oxindole and N-(2-picolinoyl) aziridine has been realized for the first time. The is efficiently mediated by a simple in-situ-generated magnesium catalyst 3,3'-fluorinated-BINOL (BINOL=1,1'-binaphthalene-2,2'-diol) identified as powerful chiral ligand. Notably, fluorine atom on ligand plays key role in providing desired 3-alkyl-3-aryl oxindoles with excellent enantioselectivities.
Macrophages are very important immune cells and play critical roles in tumour immunity. Macrophage subtypes can be divided into classical polarization (M1 macrophages) alternative (M2 under different microenvironments. Krüppel-like factor 4 (KLF4) is an essential transcription for macrophage polarization. Our previous study has shown that KLF4 SUMOylation plays role M2 In the present study, small ubiquitin-like modifier (SUMO) specific peptidase (SENP)1 was identified as a protease...
Abstract Axial naphthols are applied in asymmetric halogenative dearomatization reactions under simple and mild conditions the work presented herein. The axial‐to‐central chirality conversion is efficiently accomplished, desired halogenated products obtained high yields enantioselectivities. By using commercially available halogenation reagents, fluorinative, chlorinative brominative of axial derived from BINOLs achieved. (BINOL=1,1′‐Bi‐2‐naphthol) magnified image
Macrophages, in response to different environmental cues, undergo the classical polarization (M1 macrophages) as well alternative (M2 that involve functions of stimulus-specific transcription factors. Kruppel-like factor 4 (KLF4), a member subfamily zinc-finger class DNA-binding factors, plays critical regulator macrophage polarization. KLF4 has been reported SUMOylated protein. In this study, we showed SUMOylation KLF4, is induced by IL-4 treatment macrophages. IL4-induced promotes RAW264.7...
A magnesium-catalyzed asymmetric ring-opening reaction of aziridines with substituted tetrazoles is reported. The current protocol proceeds smoothly and gives the corresponding desymmetrization products in high yields good enantioselectivities. new chiral ligand was synthesized from azetidine (R)-BINOL employed situ generated magnesium catalyst. Mg(II)-mediated could be performed on gram scale under mild conditions transformed to alkyl amines by a deprotection process.
Background: Gastric cancer (GC) is the third leading fatal in world and its incidence ranked second among all malignant tumors China. The molecular classification of GC, proposed by Cancer Genome Atlas (TCGA), was added to updated edition(2019) WHO for digestive system tumor. Although MSI EBV subtypes appeared as ever-increasingly significant roles immune checkpoint inhibitor therapy, underlying mechanisms are still unclear. Methods: We systematically summarized relationship between EBV,...
A nickel-mediated asymmetric allylic alkylation reaction between imidazole-modified ketones and nitroallylic acetates is presented. This catalyzed by a simple chiral diamine-nickel catalyst under mild conditions leads to series of novel enantioenriched α-allylic adducts in moderate good yields with excellent enantioselectivities. Furthermore, transformation the could smoothly lead γ-nitro-esters containing three continuous stereocenters yields.
Alcoholic liver disease greatly affects human health. Previous studies have identified that microRNAs (miRNAs) are associated with the pathogenesis of alcoholic fibrosis (ALF). Therefore, present study explored regulatory mechanism miR‑148a‑3p in ALF. An ALF model was established rats by alcohol gavage, followed treatment miR‑148a‑3p. Reverse transcription‑quantitative (RT‑q) PCR performed to detect expression rat tissues. The levels lactate dehydrogenase (LDH), aspartate aminotransferase...
Abstract Growing demand for energy consumption worldwide has led to an increase in carbon emissions, which have significant effects on climate change. There is urgent need clean and renewable sources. However, most sources, such as solar wind, very high initial costs, especially when used a principal source. Distributed power generation using wind provides effective solution reduce the dependency conventional reliability quality of systems. A mixture distributed systems loads can then be...
Microgrids are the main building blocks of future smart grids. They provide a promising solution for integrating renewable energy sources and distributed power generation into The high penetration their intermittent nature have brought about significant challenges to control operation microgrids. In recent years, an enormous amount research has been conducted on microgrid dynamics, stability analysis, management, control. However, there limited effort integrate cutting-edge technologies...
Abstract A nickel‐catalyzed asymmetric oxazole‐forming Ugi reaction of C,N‐cyclic azomethine imines and isonitriles is disclosed. The reported protocol proceeds smoothly, gives the corresponding adducts, which contain two important pharmaceutically active ring‐systems (tetrahydroquinoline oxazole rings), in good yields excellent enantioselectivities by employing an easily accessible chiral diamine as a ligand. This simple efficient strategy provides easy access to series C1‐substituted aryl...
BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is a chronic, progressive with an increasing incidence rate. This study investigated the protective effects of live combined Bacillus subtilis and Enterococcus faecium (LCBE) on NAFLD, its possible mechanisms. MATERIAL AND METHODS Five-week-old C57BL/6 mice were randomly divided into 3 groups: chow, HFD, HFD+LCBE groups. The levels serum biochemical markers, glucose tolerance, insulin, inflammatory cytokines IL-1ß, IL-6, TNF-alpha, LPS,...
A magnesium catalyzed asymmetric conjugate reaction of C3-pyrrolyl-oxindoles with terminal alkynones is presented. The current relies on the development novel combinational catalysis involving two chiral ligands. protocol proceeds smoothly and gives corresponding enantioenriched 3,3-disubstituted oxindole skeletons good enantioselectivities. Furthermore, adducts could be transferred to spiro structures containing an eight-membered ring in high ee values.
A series of 2-(cyanomethyl)azaarenes containing benzothiazole or benzoxazole were designed and synthesized for asymmetric α-functionalization with N-Boc-amino sulfones. The Mannich adducts obtained in high yields good diastereo- enantioselectivities. Aryl-substituted amino sulfones tolerated under the current conditions, reaction can be performed on gram scale results.
A highly automated method was used to construct numerical models of six 3-D human right nasal cavities from computed tomography data. Steady state airflow simulations were performed with computational fluid dynamics software for quiet breath on the models. The is validated particle simulations. Simulation results each studies are compared.