A5110090186- Bipolar Disorder and Treatment
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Pharmacological Effects of Natural Compounds
- Olfactory and Sensory Function Studies
- Electroconvulsive Therapy Studies
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Biochemical Analysis and Sensing Techniques
- RNA regulation and disease
- Schizophrenia research and treatment
- Estrogen and related hormone effects
- Genetics and Neurodevelopmental Disorders
- Pain Mechanisms and Treatments
- Surgical Sutures and Adhesives
- Mycotoxins in Agriculture and Food
- Neurogenesis and neuroplasticity mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Traditional Chinese Medicine Analysis
- Hemostasis and retained surgical items
- Microbial Metabolites in Food Biotechnology
- Food Quality and Safety Studies
- Collagen: Extraction and Characterization
- Cardiac electrophysiology and arrhythmias
Yantai University
2015-2024
University of Louisville
2015-2024
Neurological Surgery
2024
Luye Pharma (China)
2006-2022
Fujian University of Traditional Chinese Medicine
2020
University of Cincinnati
2020
University of Louisville Hospital
2010-2019
North China Electric Power University
2018
Duke Medical Center
2014
Duke University
2014
Abstract: Tartrazine is an artificial azo dye commonly used in human food and pharmaceutical products. The present study was conducted to evaluate the toxic effect of tartrazine on learning memory functions mice rats. Animals were administered different doses for a period 30 d evaluated by open‐field test, step‐through Morris water maze respectively. Furthermore, biomarkers oxidative stress pathohistology also measured explore possible mechanisms involved. results indicated that extract...
The study aimed to analyze the global influences of dietary inulin with different degrees polymerization (DP) on intestinal microbial communities. Six-week-old male C57BL/6J mice were treated fructo-oligosaccharides and for 6 weeks. Fecal samples obtained at time point 0 6th week. 16S rRNA sequence analysis was used measure microbiota performed Illumina MiSeq platform. Influences more complex effects than bifidogenic effects, relative abundance butyrate-producing bacteria increased after...
Abstract Pirfenidone (PFD), an anti-fibrotic small molecule drug, is used to treat fibrotic diseases, but its effects on myocardial infarction (MI)-induced cardiac fibrosis are unknown. The aim of this study was determine the PFD MI-induced and possible underlying mechanisms in rats. After establishment model, animals were administered by gavage for 4 weeks. During development fibrosis, we found activation a positive feedback loop between angiotensin II type 1 receptor (AT1R)/phospho-p38...
In clinical practice, tissue adhesives have emerged as an alternative tool for wound treatments due to their advantages in ease of use, rapid application, less pain, and minimal damage. Since most are designed internal use or treatments, the biodegradation is important. To endow with biodegradability, past few decades, various biodegradable polymers, either natural polymers (such chitosan, hyaluronic acid, gelatin, chondroitin sulfate, starch, sodium alginate, glucans, pectin, functional...
The aim of the present study was to investigate effects gallic acid (GA) on proliferation and apoptosis colon cancer cells further clarify mechanism GA function associated with SRC EGFR phosphorylation. HCT116 HT29 were treated different concentrations for 24 h. Cell analyzed using plate clone formation flow cytometry assays, respectively. In addition, expression apoptosis‑related proteins examined by western blotting. Furthermore, level STAT3, AKT, phosphorylation blotting...
In this study, the structure, composition, cytotoxicity, and in vitro hypoglycemic activity of a polysaccharide isolated from Spirulina platensis (PSP1) its degradation fragments (PSP2, PSP3) were assessed. Structurally, PSP was identified as sulfated α-pyranose. All three tested polysaccharides found to inhibit α-glucosidase, with small-molecule PSP3 exhibiting best efficacy context. MTT assays indicated that none exhibited cytotoxic when used treat 3T3-L1 preadipocytes, whereas all able...
20(S)-ginsenoside-Rg3 (C42H72O13), a natural triterpenoid saponin, is extracted from red ginseng. The increasing use of 20(S)-ginsenoside Rg3 has raised product safety concerns.In acute toxicity, was singly and orally administrated to Kunming mice Sprague-Dawley (SD) rats at the maximum doses 1600 mg/kg 800 mg/kg, respectively. In 26-week toxicity study, we used repeated oral administration in SD over 26 weeks 0, 20, 60, or 180 mg/kg. Moreover, 4-week recovery period scheduled observe...
Type I collagen, used as a raw material, plays pivotal role in the development of medical devices and tissue engineering. Due to risk zoonotic transmission religious constraints for mammalian fish collagen gains increased attention is widely seen an alternative. In this study, two micro/nanofiber materials, self-assembled nanofiber electrospun nanofiber, were prepared by tilapia skin their biocompatibility immunogenicity was thoroughly investigated. The result revealed that state different....
After spinal cord injury (SCI), re-establishing cellular homeostasis is critical to optimize functional recovery. Central that response PERK signaling, which ultimately initiates a pro-apoptotic if cannot be restored. Oligodendrocyte (OL) loss and white matter damage drive consequences determine recovery potential after thoracic contusive SCI. We examined acute (<48 h post-SCI) chronic (6 weeks effects of conditionally deleting Perk from OLs prior While transcript expressed in many types...