A5100406389- Mesenchymal stem cell research
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Studies
- Nanoparticle-Based Drug Delivery
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Cardiac Ischemia and Reperfusion
- Neurological Complications and Syndromes
- Hemostasis and retained surgical items
- Lymphoma Diagnosis and Treatment
- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Wound Healing and Treatments
- Nerve injury and regeneration
- Neural and Behavioral Psychology Studies
- Intensive Care Unit Cognitive Disorders
- Extracellular vesicles in disease
- Signaling Pathways in Disease
- Esophageal Cancer Research and Treatment
- Memory and Neural Mechanisms
- Cerebrovascular and Carotid Artery Diseases
Nankai University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Stanford University
2022-2023
Tianjin University
2020-2023
Binzhou University
2023
Shandong Agricultural University
2023
Chengdu University of Traditional Chinese Medicine
2019-2022
Nanjing Drum Tower Hospital
2017-2022
Sichuan University
2022
West China Hospital of Sichuan University
2022
Abstract Most existing bioadhesives, even those showing superiority in wound closure effectiveness, do not assist the post‐wound process. A bioinspired, situ formed, double‐dynamic‐bond crosslinked hydrogel bioadhesive that is capable of efficiently closing open wounds and enabling care reported. Catechol‐modified ε‐poly‐ l ‐lysine oxidized dextran are employed as natural polymer backbones they using Schiff's base dynamic bond catecholFe coordinate through a process inspired by used to cure...
Abstract From June 2011 to August 2014, 21 cases of infection by severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) were confirmed in Zhoushan Islands the Eastern coast China. To identify source SFTSV Islands, whole genomes amplified and sequenced from 17 patients. The L, M S genomic segments these strains phylogenetically analyzed together those 188 available GenBank. Phylogenetic analysis demonstrated could be classified into six genotypes. genotypes F, A D dominant mainland...
Blood transferrin receptor-positive (TfR+) exosomes are a kind of optimized drug delivery vector compared with other kinds due to their easy access and high bio-safety. Their application facilitates the translation from bench bedside exosome-based vehicles. Methods: In this study, pH-responsive superparamagnetic nanoparticles cluster (denoted as SMNC)-based method was developed for precise mild separation blood TfR+ exosomes. Briefly, multiple (SPMNs) labeled transferrins (Tfs) could...
Myocardial ischemia-reperfusion injury (MIRI) is a type of severe to the ischemic myocardium that can occur following recovery blood flow, and for which, there no effective treatment. Panaxatriol saponin (PTS), major active component P. notoginseng, has been used clinically treat ischemia-related encephalopathy due its antioxidant activity, but effect on cardiomyopathy underlying mechanism action still unclear. This study was performed investigate protective PTS against MIRI explore...
Deep gray matter structures are associated with memory and other important functions that impaired in Alzheimer's disease (AD) mild cognitive impairment (MCI). However, systematic characterization of the subregional atrophy deformations these AD MCI still need more investigations. In this article, we combined complex volumetry- vertex-based analysis to investigate pattern structural alterations deep its association global clinical scores (n = 30) patients 30), compared normal controls (NCs,...
Journal of Mechanics in Medicine and BiologyAccepted Papers No AccessMulti-slice mri classification for alzheimer's disease diagnosis with deep learningYang Chen, Siyao Lu, Heng Zhang, Teng-Teng Xueping Li, Caixu Xu, Zhipeng Gong, Haixiao GongYang Lu Search more papers by this author , Zhang Li Xu Gong https://doi.org/10.1142/S0219519425400287Cited by:0 (Source: Crossref) PreviousNext AboutFiguresReferencesRelatedDetailsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend...
Background: DNA methylation is a common event in the early development of various tumors, including breast cancer (BRCA), which has been studies as potential tumor biomarkers. Although previous have reported cluster aberrant promoter changes BRCA, none these research groups proved specificity changes. Here we aimed to identify specific signatures BRCA can be used diagnostic and prognostic markers. Methods: Differentially methylated sites were identified using Cancer Genome Atlas (TCGA) data...
Composting is an effective method of recycling organic solid waste, and it the key process linking planting with recycling. To explore reuse agricultural waste as a resource in Yellow River Delta, effects microbial inoculant different additives (calcium superphosphate, biochar, tomato straw, rice husk, sugar residue) on pile composting cow dung were studied to obtain best conditions. The results showed that all played positive roles aerobic composting, experimental groups outperformed...
Abstract Background Continuous cross talk between MSCs and macrophages is integral to acute chronic inflammation resulting from contaminated polyethylene particles (cPE); however, the effect of this inflammatory microenvironment on mitochondrial metabolism has not been fully elucidated. We hypothesized that (a) exposure cPE leads impaired glycolytic reprogramming (b) play a key role in pathway. Methods cultured with/without uncommitted M0 macrophages, 3-dimensional gelatin methacrylate (3D...
Lung adenocarcinoma (LUAD) is one of the most malignant tumor types worldwide. Our objective was to identify a genetic signature that could predict prognosis patients with LUAD. We extracted gene data sets from The Cancer Genome Atlas and obtained differentially expressed genes were highly at every stage. These analyzed using set enrichment analysis obtain four biological processes associated Subsequently, Cox univariate multivariate analyses performed generate optimized models (G2M...
Abstract Background Lingguizhugan decoction (LGZG), an ancient Chinese herbal formula, has been used to treat cardiovascular diseases in eastern Asia. We investigated whether LGZG protective activity and the mechanism underlying its effect animal model of heart failure (HF). Methods A rat HF was established by administering eight intraperitoneal injections doxorubicin (DOX) (cumulative dose 16 mg/kg) over a 4-week period. Subsequently, at 5, 10, 15 mL/kg/d administered rats intragastrically...
Abstract Background The tumor microenvironment (TME) plays a critical role in tumorigenesis, development, and therapeutic efficacy. Major advances have been achieved the treatment of various cancers through immunotherapy. Nevertheless, only minority patients positive responses to immunotherapy, which is partly due conditions immunosuppressive microenvironment. Therefore, it essential identify prognostic biomarkers that reflect heterogeneous landscapes TME. Methods materials Based upon...
It is well known that chitosan has beneficial lipid-regulating effects, but it remains unknown whether oligosaccharide (COS), the degradation product, same lipid benefits. High-fat-diet-fed Wistar rats were administrated with COS by gastric gavage for three weeks. The effects of on lipids, lipoprotein components and metabolism related protein activities investigated. Plasma lipids level assays an enzyme method showed decreased triglyceride (TG) 29-31%, increased high-density (HDL)...
Abstract Introduction Perioperative urinary tract infections (PUTIs) are common in the United States and a significant contributor to high healthcare costs. There is lack of large studies on risk factors for PUTIs after total hysterectomy (TH). Methods We conducted retrospective study using national inpatient sample (NIS) 445,380 patients from 2010 2019 analyze annual incidence associated with TH perioperatively. Results were found 9087 overall, showing 2.0% incidence. substantial...
Raven's Matrices test (RMT) is a non-verbal designed to assess individuals' ability reason and solve new problems without relying extensively on declarative knowledge derived from schooling or previous experience. Despite large number of behavioral studies that demonstrated gender differences in reasoning ability, no neural evidence supported this difference. In study, voxel-based morphometry (VBM) was used an attempt uncover the gender-specific basis as measured by combined (CRT) 370...
The intestinal epithelium is considered to be a major obstacle the gastrointestinal administration for water-insoluble drugs. To enhance absorption of paclitaxel by improving its solubility and overcoming barrier, transferrin-modified nanocrystals were prepared based on specific transferrin receptor expressed apical membrane examined exhibit mean size around 178 nm, rod-like morphology, sustained release property, an enhanced in vitro antitumor effect. situ perfusion study proved that was...
Social anxiety is one of the psychological symptoms that most commonly occur in social interaction. Although previous behavioral studies have investigated neutral-angry facial emotion change anxiety, none have, however, directly angry-neutral emotional change. Furthermore, less known about neural correlates changes individuals with anxiety. The main goal present study was to explore perception using high temporal resolution event-related potential techniques. Behaviorally, accuracy trail...