A5064539539- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Dendrimers and Hyperbranched Polymers
- Click Chemistry and Applications
- Immunotherapy and Immune Responses
- Advanced Drug Delivery Systems
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Lattice Boltzmann Simulation Studies
- Biological Research and Disease Studies
- Bone Metabolism and Diseases
- Histone Deacetylase Inhibitors Research
- Polymer Surface Interaction Studies
- Epigenetics and DNA Methylation
- Solar-Powered Water Purification Methods
- Dental Trauma and Treatments
Qingdao University
2018-2025
Affiliated Hospital of Qingdao University
2020-2025
Tianjin University
2014-2021
Qingdao Center of Resource Chemistry and New Materials
2020
Exosomes are a class of naturally occurring nanoparticles that secreted endogenously by mammalian cells. Clinical applications for exosomes remain challenge because their unsuitable donors, low scalability, and insufficient targeting ability. In this study, we developed dual-functional exosome-based superparamagnetic nanoparticle cluster as targeted drug delivery vehicle cancer therapy. The resulting exhibits behavior at room temperature, with stronger response to an external magnetic field...
Rationale: Developing an effective nanoplatform to realize 'multi-in-one' is essential broaden the therapeutic potential of combination therapy. Exosomes are ideal candidates since their intrinsic abilities integrating multiple contents and functions. However, only limited efforts have been devoted engineering exosomes integrate needed properties, also considering safety yield, for tumor-targeted efficient gene/chemo Methods: Herein, by manipulating exosome membrane, blood with high...
As an essential component of immunotherapy, monoclonal antibodies (mAbs) have emerged as a class powerful therapeutics for treatment broad range diseases. For central nervous system (CNS) diseases, however, the efficacy remains limited due to their inability enter CNS. A platform technology is reported here that enables effective delivery mAbs CNS brain tumor therapy. This achieved by encapsulating within nanocapsules contain choline and acetylcholine analogues; such analogues facilitate...
Exosomes play critical roles in intercellular communication both nearby and distant cells individuals organs.Polymerase I transcript release factor (PTRF), also known as Cavin1, has previously been described a caveola formation, aberrant PTRF expression reported various malignancies.However, the function of tumor progression remains controversial, its role glioma is poorly understood.In this study, we report that associated with malignancy grade poor prognosis patients.Our previous study...
Mesenchymal stromal cells (MSCs) are attractive candidates for treating hepatic disorders given their potential to enhance liver regeneration and function. The paracrine paradigm may be involved in the mechanism of MSC-based therapy, exosomes (Exo) play an important role this activity. Hypoxia significantly improves effectiveness MSC transplantation. However, whether hypoxia preconditioned MSCs (Hp-MSCs) can regeneration, enhancement is mediated by Exo, unknown. In study, mouse bone...
Blood transferrin receptor-positive (TfR+) exosomes are a kind of optimized drug delivery vector compared with other kinds due to their easy access and high bio-safety. Their application facilitates the translation from bench bedside exosome-based vehicles. Methods: In this study, pH-responsive superparamagnetic nanoparticles cluster (denoted as SMNC)-based method was developed for precise mild separation blood TfR+ exosomes. Briefly, multiple (SPMNs) labeled transferrins (Tfs) could...
Abstract This study aimed to evaluate the potential of long noncoding RNA s (lnc s) as biomarkers for coronary artery disease ( CAD ). We measured levels three atherosclerosis‐ or cardiac‐related lnc in peripheral blood monocyte cells PBMC from 20 patients and non‐ control participants using real‐time reverse transcription–polymerase chain reaction (real‐time RT – PCR ) methods. found that KCNQ 1 opposite strand/antisense transcript OT 1), hypoxia‐inducible factor alpha‐antisense 2 HIF 1A‐...
Abstract Triple-negative breast cancer (TNBC) exhibits a high mortality rate and is the most aggressive subtype of cancer. As previous studies have shown that histone deacetylases (HDAC) may represent molecular targets for TNBC treatment, we screened small library synthetic molecules identified potent HDAC inhibitor (HDACi), YF438, which exerts effective anti-TNBC activity both in vitro vivo. Proteomic biochemical revealed YF438 significantly downregulated mouse double minute 2 homolog...
Oral gene therapy has emerged as a potential optimal treatment for ulcerative colitis (UC). Nucleic acid drugs possessing versatility can not only inhibit inflammation but realize colon mucosal healing, fulfilling the clinical objective of UC therapy. However, effective accumulation and distribution oral nucleic in remain considerable challenge. Furthermore, current delivery systems pay more attention to colon, while which plays key role treatment, never catches researchers. Here, we used...
Abstract Aortic dissection (AD) is a severe cardiovascular disease necessitating active therapeutic strategies for early intervention and prevention. Nucleic acid drugs, known their potent molecule‐targeting properties, offer potential genetic suppression of AD. Piwi‐interacting RNAs, class small hold promise managing diseases. Limited research on these RNAs AD exists. This study demonstrates that an antagomir targeting heart‐apoptosis‐associated piRNA (HAAPIR) effectively regulates vascular...
Abstract Background/Aims This study sought to evaluate the potential of circulating microRNAs (miRNAs) as novel indicators for acute myocardial infarction (AMI). Methods Plasma samples were collected from each participant, and total RNA was extracted. Quantitative real‐time polymerase chain reaction used investigate expression miRNAs. We measured levels six individual miRNAs, which are known be relevant AMI, in plasma 66 AMI patients 70 non‐AMI healthy comparisons. Results Five small RNAs...
The healing of osteoporotic fractures in the elderly patients is a difficult clinical problem. Currently, based on internal fixation fractures, available drug treatments mainly focus either inhibiting osteoclast function, such as bisphosphonate, calcitonin, oestrogen or promoting osteogenesis, parathyroid hormones. However, availability current antiosteoporotic drugs fracture limited. objective present study was to investigate ability MiR-21/nanocapsule enhance early bone repair...
Abstract The use of circulating microRNAs as biomarkers opens up new opportunities for the diagnosis cardiovascular diseases because their specific expression profiles. aim present study was to identify in human plasma potential heart failure and related diseases. We used real-time quantitative PCR screen microRNA samples from 62 normal controls samples. found that miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a miR-217 expressed differently between healthy patients. Plasma levels...
Cell-based immunotherapy for the treatment of hematologic malignancies, such as leukemia and lymphoma, has seen much success played an increasingly important role in clinical studies.Nevertheless, efficacy solid tumors still needs improvements due to immunosuppressive properties tumor cells microenvironment.To overcome these limitations, we prepared a novel tumor-targeting delivery system based on underlying mechanism immune-targeted cell death that encapsulated granzyme B protein within...
Taking the advantages of unique physiological character bone fracture, a systemic delivery platform growth factors for repair based on nanocapsules was exploited.
Abstract Coronary artery disease (CAD) is one of the biggest threats to human life. Circulating microRNAs (miRNAs) have been reported be linked pathogenesis CAD, indicating possible role in CAD diagnosis. The present study aimed explore expression profile plasma miRNAs and estimate their value diagnosis for CAD. 67 Non‐CAD control subjects 88 patients were enrolled. We conducted careful evaluation by RT‐PCR analysis, Spearman rank correlation coefficients Receiver Operating Characteristic...