A5072577389- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- S100 Proteins and Annexins
- Biochemical and Molecular Research
- Computational Drug Discovery Methods
- Radiopharmaceutical Chemistry and Applications
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Pancreatic and Hepatic Oncology Research
- Kruppel-like factors research
- Optical measurement and interference techniques
- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Advanced Vision and Imaging
- NF-κB Signaling Pathways
- Bioinformatics and Genomic Networks
- Natural Compounds in Disease Treatment
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Optical Systems and Laser Technology
- Peptidase Inhibition and Analysis
- Immune cells in cancer
China Medical University
2019-2024
University of Toyama
2017
Triple negative breast cancer (TNBC) is a specific subtype of with poor prognosis due to its aggressive biological behaviour and lack therapeutic targets. We aimed explore some novel genes pathways related TNBC through bioinformatics methods as well potential initiation progression mechanisms.Breast mRNA data were obtained from The Cancer Genome Atlas database (TCGA). Differential expression analysis adjacent cancer, as, triple non-triple performed using R software. key the pathogenesis...
Cancer stem cells (CSCs) are responsible for the migration and recurrence of cancer progression. Small nucleolar RNAs (snoRNAs) play important roles in tumor development. However, how snoRNAs contribute to regulation stemness ovarian CSCs (OCSCs) remains unclear. In present study, we found that SNORA72 was significantly upregulated OVCAR-3 spheroids (OS) CAOV-3 (CS) with OCSC characteristics attained by serum-free culture a suspension (OV) (CA) cells. The overexpression increased...
Lung adenocarcinoma (LUAD) is one of the most malignant tumor types worldwide. Our objective was to identify a genetic signature that could predict prognosis patients with LUAD. We extracted gene data sets from The Cancer Genome Atlas and obtained differentially expressed genes were highly at every stage. These analyzed using set enrichment analysis obtain four biological processes associated Subsequently, Cox univariate multivariate analyses performed generate optimized models (G2M...
Hepatocellular carcinoma (HCC) is an aggressive cancer that has effect on human health. As a first-line drug for HCC, despite its excellent efficacy, lenvatinib (Len) prone to developing resistance in HCC patients. The N6-methyladenosine (m6A) modification not only related the development of but also shows great potential overcoming resistance. Using Dot Blot, our group first screened small molecule m6A regulator, lobeline (Lob), from library 390 compounds (mostly natural products). In vitro...
Cancer cell resistance to chemotherapy is one of the obstacles for better cancer treatment, and inflammatory signaling pathways, such as NF-κB pathway, have been recognized be involved in chemoresistance. In this study, we aim identify a new approach overcoming chemoresistance by using natural compounds. As result screening Murine B16F10 melanoma line constitutively expressing luciferase reporter gene, identified Saikosaponin B2 an effective inhibitor etoposide-induced activation B16F10NFkB...
Annexin A2 (ANXA2) encodes an oncoprotein whose expression has been found to correlate with poorer overall survival (OS) of pancreatic adenocarcinoma (PAAD) patients. Although peptides are available for targeting ANXA2, none these were initially selected target this protein specifically. Here, we took ANXA2 as a molecular PAAD and employed the phage display technique screen new ANXA2-targeted peptide. The resultant heptapeptide, YW7, was firstly labeled fluorescein isothiocyanate (FITC)...
A simple and effective external parameter calibration optimize method based on epipolar geometry for improving the accuracy stabilization of 3D optical measurement system are present.First, internal parameters two cameras calibrated using planar method.Then as initial value calibrates in every view.Optimization result is computed through minimizing line error same pair points view.Experimental results show that precision high stable volume.