A5077356092- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Nutrition and Health in Aging
- Breast Cancer Treatment Studies
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Childhood Cancer Survivors' Quality of Life
- Ferroptosis and cancer prognosis
- Diet and metabolism studies
- Cytokine Signaling Pathways and Interactions
- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Circular RNAs in diseases
- Sarcoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Bioinformatics and Genomic Networks
- Insect Resistance and Genetics
- MicroRNA in disease regulation
Tang Du Hospital
2023
Air Force Medical University
2023
Emory University
1995-2022
China Medical University
2019-2021
National Cancer Institute
1996
The VHL tumor suppressor gene is inactivated in patients with von Hippel-Lindau disease and most sporadic clear cell renal carcinomas. Although protein function remains unclear, does interact the elongin BC subunits vivo regulates RNA polymerase II elongation activity vitro by inhibiting formation of ABC complex. Expression wild-type carcinoma cells endogenous resulted unaltered growth decreased vascular endothelial factor (VEGF) mRNA expression responsiveness to serum deprivation. VEGF...
Triple negative breast cancer (TNBC) is a specific subtype of with poor prognosis due to its aggressive biological behaviour and lack therapeutic targets. We aimed explore some novel genes pathways related TNBC through bioinformatics methods as well potential initiation progression mechanisms.Breast mRNA data were obtained from The Cancer Genome Atlas database (TCGA). Differential expression analysis adjacent cancer, as, triple non-triple performed using R software. key the pathogenesis...
Increasing studies have suggested that aberrant expression of microRNAs might play essential roles in the progression cancers. In this study, we sought to construct a high-specific and superior signature improve survival prediction colon adenocarcinoma (COAD) patients.The genome-wide miRNAs, mRNA lncRNA profiles corresponding clinical information COAD were collected from TCGA database. Differential analysis, Kaplan-Meier curve time-dependent ROC calculated performed using R software GraphPad...
Abstract Gastric cancer (GC) is one of the most fatal common cancers in worldwide. Helicobacter pylori ( H. ) infection closely related to development GC, although mechanism still unclear. In our study, we aim develop a robust messenger RNA (mRNA) signature associated with (‐) GC that can sensitively and efficiently predict prognostic. The RNA‐seq expression profile corresponding clinical data 598 gastric samples 63 normal obtained from Cancer Genome Atlas (TCGA) Gene Expression Omnibus...
Malnutrition is a common complication in children with cancer. Cancer treatment and malnutrition can disrupt gut microbiome diversity composition. The of broad interest to better understand the mechanisms cancer therapy. This study aimed compare between solid tumors postchemotherapy healthy controls, investigated association putative differences diet. Study participants were 27 (7–18 years) within first year after completion chemotherapy 22 controls. groups did not have statistically...
Background: Malnutrition is a common complication in children with cancer. Cancer treatment and malnutrition can disrupt gut microbiome diversity composition. This study aims to compare the dietary intakes between solid tumors post-chemotherapy healthy controls, investigate associations microbiome. Procedure: Children (7-18 years) were recruited during year 1 after completion of chemotherapy from Children’s Healthcare Atlanta, Georgia. Healthy controls via flyers. completed Block Kids Food...
Abstract Background China is a country with high incidence of gastric cancer, accounting for about half the new cases in world every year. The development Gastric cancer (GC) closely related to Helicobacter pylori (H. pylori) infection. Cancer stem cells (CSCs) play important roles survival, proliferation, metastasis and recurrence tumors. However, mechanism CSCs H. pylori-induced GC remains unclear.At same time, effect tumor microenvironment on infection also worth exploring. On basis...