A5100447669- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Cytokine Signaling Pathways and Interactions
- Gastric Cancer Management and Outcomes
- Drug Transport and Resistance Mechanisms
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Uterine Myomas and Treatments
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Breast Lesions and Carcinomas
- Cancer-related cognitive impairment studies
- Endometriosis Research and Treatment
- Esophageal Cancer Research and Treatment
- HER2/EGFR in Cancer Research
Chongqing Medical University
2024
Jiangsu Cancer Hospital
2015-2024
Nanjing Medical University
2015-2024
Third Affiliated Hospital of Harbin Medical University
2012-2024
Jiangsu Province Hospital
2009-2024
Kunming Institute of Botany
2023-2024
Harbin Medical University
2013-2024
Wake Forest University
2024
Shaanxi Normal University
2023
Northwest University
2023
Exosomes are small extracellular membrane vesicles of endocytic origin released by many cells that could be found in most body fluids. The main functions exosomes cellular communication and waste clean-up. This study was conducted to determine the involvement regulation sensitivity lung cancer cell line A549 cisplatin (DDP). When DDP added cells, secretion strengthened. Addition secreted other increased resistance these DDP. Upon exposure DDP, expression levels several miRNAs mRNAs...
Vitamin D insufficiency/deficiency during pregnancy has been linked to increased risk of preeclampsia. Placenta dysfunction plays an important role in the pathogenesis this disorder. In study, we tested hypothesis that disturbed vitamin metabolism takes place preeclamptic placentas. Protein expressions binding protein (VDBP), 25-hydroxylase (CYP2R1), 1α-hydroxylase (CYP27B1), 24-hydroxylase (CYP24A1), and receptor (VDR) were examined placentas from normotensive pregnancies. By immunostaining...
Over the past several years, long non‐coding RNAs (lncRNAs) have attracted more and attention due to their special functions. They are vital biomarkers in multiple diseases. LncRNA HOMEOBOX A11 (HOXA11) has been found be aberrantly expressed some kinds of malignant tumors. In this study, we mainly discuss oncogenic role it promoting progression chemoresistance lung adenocarcinoma (LUAD) cells. The expression HOXA11‐AS was much stronger cisplatin‐resistant LUAD Based on Cancer Genome Atlas...
The aims of this study were to assess whether in utero exposure untreated gestational diabetes (using the IADPSG criteria) is associated with long-term risk a disorder glucose metabolism among mothers and greater adiposity their children at 10 14 years post-partum.
Increasing studies showed that kinesin family member 20A (KIF20A) was overexpessed in several types of cancer, and its overexpression correlated with the oncogenesis prognosis cancers. However, little is known about role KIF20A lung adenocarcinoma (LUAD). In this study, we employed bioinformatics analysis to identify upregulation LUAD, then verified results human tumor specimens LUAD cell lines. Compared normal tissues, a ubiquitous observed tissues by immunohistochemistry (IHC) as well TCGA...
Circular RNAs (circRNAs) are involved in regulating of carcinogenesis various cancer cells. However, the function circRNAs colorectal (CRC) has remained largely unknown. This study investigated characteristic expression CRC and adjacent normal tissues, analyzed miRNAs related to candidate circRNAs, studied correlation between with clinical data CRC.
Breast cancer is the second leading cause of cancer‑related mortality in females worldwide. Therefore, identifying alternative strategies to combat disease important. The aim present study was investigate effect tanshinone I (Tan I) on tumorigenicity estrogen‑responsive MCF‑7 and estrogen‑independent MDA‑MB‑453 human breast cells. cytotoxicity Tan evaluated using a Cell Counting Kit‑8 assay, apoptosis cell cycle distribution were detected flow cytometry morphology observed fluorescence...
In recent years, the incidence of non‑small cell lung cancer (NSCLC) has become highest lethal rate worldwide. Molecular assays EGFR, KRAS, BRAF, NRAS, PIK3CA and Her‑2 are widely used to guide individualized treatment in NSCLC patients. Somatic mutations 112 patients, including 7 oncogenic driver genes, were detected by Iontorrent personal genome machine (PGM). Sanger sequencing was test verify results PGM. Apart from uncommon 101 specimens tested droplet digital PCR (ddPCR). According NGS...
Homoharringtonine (HHT), a natural alkaloid derived from the cephalotaxus, exhibited its anti-cancer effects in hematological malignancies clinically. However, pesticide and mechanisms treating solid tumors remain unclear. In this study, we found that HHT was capable of inhibiting tumor growth after 5-days treatment breast cancer cells, MCF-7, vivo. Furthemore, also significantly inhibited cell induced apoptosis vitro. miRNA sequencing proved miR-18a-3p noticeably downregulated cells...
Abstract Long noncoding RNAs (lncRNAs) serve critical roles in multiple human malignant tumors, including prostate cancer (PCa). Currently, the biological role of oncogenic lncRNA SNHG12 PCa remains largely unclear. In present study, we found that was highly expressed tissues and cell lines. addition, gain‐of‐function loss‐of‐function studies showed overexpression promoted, while downregulation suppressed proliferation, invasion, migration cells vitro. Knockdown also repressed xenograft...
Although immunotherapy has changed the prognosis of many advanced malignancies including lung adenocarcinoma (LUAD), patients are insensitive to drugs, with mechanisms yet be elucidated. Herein, we identified PDE4D as an efficacy-related gene through bioinformatics screening. By using a co-culture system LUAD cells and tumor-cell-specific CD8+ T cells, functional PDE4D/cAMP/IL-23 axis was further revealed in cells. Fluorescent multiplex immunohistochemistry analysis patient-derived samples...
Abstract Most of the patients with lung cancer are diagnosed at advanced stage, and they often lose opportunity surgical therapy, most whom fail to reach good prognosis after chemotherapy. Recently, a few clinical studies have confirmed role adoptive T-cell transfer in maintenance therapy patients. Here, we provided statistical insights into CIKs from three different levels, cell model (in vitro co-culture system), mice situ cancer), research progression stages). We optimized components...
Abstract This study was intended to analyze effects of lncRNA CRNDE on cervical cancer cell growth and metastasis. Fifty pairs tissues corresponding adjacent were collected. Expressions long non-coding RNAs (lncRNAs) in tissue samples detected by microarray analysis. Expression levels cells normal qRT-PCR. Cell-counting kit-8 (CCK-8) assay clone formation utilized evaluate growth. Wound healing Transwell conducted detect the migratory invasive capability cells. The expressions higher than...
Ellagic acid has been reported to possess various activities, including anti-inflammatory, anti-oxidative, antiviral and anticancer abilities. However, the effect underlying molecular mechanism of ellagic on cervical carcinoma remain unclear. Therefore, present study aimed investigate effects human cells involved. The assessed survival HeLa cultured in vitro using an MTT assay. Apoptosis rate cell cycle HaLa were measured Annexin V‑Fluorescein isothiocyanate/propidium iodide Detection Cell...
Abstract Long noncoding RNAs (lncRNAs) are aberrantly expressed in various cancers types and can function as competing endogenous (ceRNAs), which promote maintain tumor initiation progression. In this study, we explored the functional roles regulatory mechanisms of lncRNAs ceRNAs colorectal cancer their clinical potential biomarkers. The RNA sequencing profiles patients with were downloaded from TCGA database, 62 lncRNAs, 30miRNAs, 59 mRNAs identified to comprise ceRNA network (fold change...
Abstract Background Lung adenocarcinomas (LUAD) remain the leading cause of death in many countries. In this study, we investigated role division cycle‐associated 4 (CDCA4) carcinogenesis LUADs. Methods Real‐time fluorescent quantitative polymerase chain reaction and western blot were performed to detect messenger RNA protein levels CDCA4 cells. Cell counting kit 8, real‐time cell analysis, clone formation, EdU assays, cell‐cycle assays used preliminarily investigate proliferation...
Breast cancer is one of the most common malignancies in women. This study was conducted to analyze association between expressions eight immunohistochemical (IHC) indices and clinicopathological characteristics breast cancers (BCs) investigate clinical significance. IHC Envision ldpe-g-nvp used detect expression estrogen receptor (ER), progesterone (PR), human epidermal growth factor receptor-2 (HER2), vascular endothelial (VEGF), (EGFR), p53, type II topoisomerase (TOPO II) Ki-67...
Tripartite motif-containing 44 (TRIM44) has been demonstrated to be important in tumor metastasis and progression. However, the expression pattern prognostic value of TRIM44 epithelial ovarian cancer (EOC) remain fully elucidated. In present study, aim was investigate clinical role EOC. A total 109 patients, who underwent primary surgery with goal maximal resection followed by standard combination chemotherapy carboplatin paclitaxel, were analyzed study. The level determined western blot...
Abstract To gain an insight into the molecular mechanisms of cetuximab resistance in colorectal cancer, we generated a cetuximab‐resistant cell line (H508/ CR ) and performed RNA sequencing to identify differential expression patterns noncoding s (nc s) mRNA between cetuximab‐sensitive resistant cells. A total 278 nc transcripts 1,059 were dysregulated The levels nine selected long (lnc validated using quantitative real‐time PCR . Functional analysis revealed that several groups lnc might be...