A5100319103- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- interferon and immune responses
- Immune cells in cancer
- Atrial Fibrillation Management and Outcomes
- Mast cells and histamine
- Immunotherapy and Immune Responses
- Aquaculture disease management and microbiota
- Cancer Immunotherapy and Biomarkers
- Cardiac Arrhythmias and Treatments
- Osteoarthritis Treatment and Mechanisms
- Invertebrate Immune Response Mechanisms
- Reproductive System and Pregnancy
- Multiple Sclerosis Research Studies
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Circular RNAs in diseases
- Adrenal Hormones and Disorders
First Affiliated Hospital of Kunming Medical University
2016-2025
Kunming Medical University
2016-2025
Ruijin Hospital
2025
Shanghai Jiao Tong University
2025
Shanghai Institute of Hematology
2025
Fujian Agriculture and Forestry University
2025
Ministry of Agriculture and Rural Affairs
2024-2025
Heilongjiang University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2020-2024
This study aimed to probe into the associations among circular RNA ZFR (circ-ZFR), miR-130a/miR-107, and PTEN, investigate regulatory mechanism of circ-ZFR‒miR-130a/miR-107‒PTEN axis in gastric cancer (GC).
A new nodavirus, named covert mortality nodavirus (CMNV), is associated with disease of shrimp which has caused serious loss in China since 2009. Histopathological examination suffering the revealed coagulative necrosis striated muscle similar to typical histopathology features infectious myonecrosis virus (IMNV), Penaeus vannamei (PvNV) and Macrobrachium rosenbergii (MrNV). However, this tested negative for IMNV, MrNV PvNV by reverse transcription (RT)-PCR. Additionally, eosinophilic...
Environmental factors play an important role in the development of rheumatoid arthritis (RA). Among these factors, smoking is generally considered to be established risk factor for RA. Data regarding impact diet on RA limited. This study assessed dietary patterns susceptibility Chinese populations. was a large scale, case-control composed 968 patients with and 1037 matched healthy controls. Subjects were recruited from 18 teaching hospitals. Socio-demographic characteristics intakes 5 years...
Although laboratory studies have implicated the high mobility group box 1 (HMGB1) in melanoma, its clinical relevance remains unclear. We analyzed nearly 100 cases of human melanoma and found that HMGB1 was highly overexpressed samples relative to normal skin nevi tissues. Significantly, higher levels correlated with more advanced disease stages poorer survival patients. Unlike well-documented pro-inflammatory role extracellular HMGB1, we intracellular activity is necessary for cell...
Depressive and anxiety disorders are frequently observed in patients with Systemic Lupus Erythematosus (SLE). However, the underlying mechanisms still unknown. We conducted this survey to understand prevalence of depression SLE without major neuropsychiatric manifestations (non-NPSLE) explore relationship between emotional disorders, symptoms, autoantibodies, disease activity, treatments SLE. 176 were included, activity index (SLEDAI), Hamilton Depression Rating Scale (HAMD), Anxiety (HAMA)...
Abstract Background Targeting CD47/SIRPα axis has emerged as a promising strategy in cancer immunotherapy. Despite the encouraging clinical efficacy observed hematologic malignancies through CD47-SIRPα blockade, there are safety concerns related to binding of anti-CD47 antibodies CD47 on membrane peripheral blood cells. Methods In order enhance selectivity and therapeutic antibody, we developed humanized monoclonal antibody called Gentulizumab (GenSci059). The capacity GenSci059 was...
Abstract Aims Dedicator of Cytokinesis 2 (DOCK2), a member the DOCK family Guanine nucleotide exchange factors that specifically act on Rho GTPases including Rac and Cdc42, plays pivotal roles in regulation leukocyte homeostasis. However, its functions platelets remain unknown. Methods Results Using mice with genetic deficiency DOCK2 (Dock2-/-), we showed Dock2-/-mice exhibited macrothrombocytopenic phenotype characterized as decreased platelet count enlarged size by transmission electron...
Tomato (Solanum lycopersicum L.) is a major economic vegetable crop globally, yet it prone to gray mold disease caused by Botrytis cinerea infection during cultivation. Caffeoyl shikimate esterase (CSE) crucial component of the lignin biosynthesis pathway, which significantly contributes plant stress resistance. Therefore, investigating expression patterns SlCSE after may offer theoretical foundation for breeding resistant tomato varieties. In this study, 11 family members were identified...
Systemic lupus erythematosus patients' brain functional network impairments are incompletely clarified. This study investigates the topological alterations in systemic and application of machine learning to classification healthy controls. Resting-state MRI data from 127 patients 102 controls were used. The pre-processing process involved using automated anatomical labelling atlas compute time series for 116 regions. A connectivity was then created by assessing Pearson correlation between...
To study changes in blood brain barrier (BBB) permeability systemic lupus erythematosus (SLE) patients, and explore the association between alterations BBB depression/anxiety SLE. Brain dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) images were collected from 42 SLE patients 23 healthy controls (HCs). Based on Patlak pharmacokinetic model, Ktrans value of each voxel whole subject was calculated. indicator (the value) control group compared. Hamilton Depression Scale (HAMD)...
Abstract Macrophages possess a diverse range of well‐defined capabilities and roles as phagocytes, encompassing the regulation inflammation, facilitation wound healing, maintenance tissue homeostasis, serving crucial element in innate immune response against microbial pathogens. The emergence extracellular traps is novel strategy defense that has been observed several types cells. In to infection, macrophages are stimulated produce macrophage (METs), which take form net‐like structures,...
Functional roles of SIGLEC15 in hepatocellular carcinoma (HCC) were not clear, which was recently found to be an immune inhibitor with similar structure inhibitory B7 family members. expression HCC explored public databases and further examined by PCR analysis. PD-L1 patterns samples through immunohistochemistry. knocked-down or over-expressed cell lines, CCK8 tests used examine proliferative ability vitro. Influences on tumor growth deficient immunocompetent mice respectively. Co-culture...
The response to glucocorticoids (GCs) for patients with systemic lupus erythematosus (SLE) is characterized by wide interindividual variability, a significant number of who have no response. We analyzed whether genetic polymorphisms within glucocorticoid receptor (GR) gene are related variability in the efficacy GCs Chinese population SLE. A cohort 220 SLE was studied. These were treated (prednisone) 12 weeks. measured scores on disease activity index (SLEDAI). Patients classified into two...
Tripartite motif-containing 44 (TRIM44) has been demonstrated to be important in tumor metastasis and progression. However, the expression pattern prognostic value of TRIM44 epithelial ovarian cancer (EOC) remain fully elucidated. In present study, aim was investigate clinical role EOC. A total 109 patients, who underwent primary surgery with goal maximal resection followed by standard combination chemotherapy carboplatin paclitaxel, were analyzed study. The level determined western blot...
Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the main causes death in patients with (SLE). Signs and symptoms NPSLE are heterogeneous, it hard to diagnose, treat early stage. We conducted this study explore possible brain activity changes using resting state functional magnetic resonance imaging (rs-fMRI) SLE without major neuropsychiatric manifestations (non-NPSLE patients). also tried investigate associations among activity, disease depression, anxiety. In our study, 118...
Abstract We previously documented that M2-like macrophages exert a hepatoprotective effect in acute-on-chronic liver failure (ACLF) by inhibiting necroptosis signalling. Nevertheless, the molecular mechanism behind this hepatoprotection still needs to be further dissected. Galectin-3 (GAL3) has been reported critically involved pathogenesis of multiple diseases, whereas potential role GAL3 ACLF remains explored. Herein, we hypothesised plays pivotal conferred necroptosis. To test hypothesis,...
Aeromonas caviae (A. caviae) is one of the major etiological agents in human intestinal infections reported to be associated with a broad spectrum extra-intestinal increasing incidence over recent years. Although previous studies have established its significance as causative agent both bloodstream and gastrointestinal infections, characteristics A. that cause remain unilluminated.In this single-center retrospective study, we investigated epidemiological characteristics, antimicrobial...