A5025500195- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- 14-3-3 protein interactions
- Wnt/β-catenin signaling in development and cancer
- interferon and immune responses
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- Parathyroid Disorders and Treatments
- Mesenchymal stem cell research
- Lipid metabolism and biosynthesis
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Cancer Research and Treatments
- NF-κB Signaling Pathways
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Thyroid Cancer Diagnosis and Treatment
Xiangya Hospital Central South University
2021-2024
Central South University
2021-2024
Hunan Cancer Hospital
2022
Zhongnan Hospital of Wuhan University
2019-2021
Wuhan University
2019-2021
Hepatocellular carcinoma (HCC) is a lethal and aggressive human malignancy. The present study examins the anti-tumor effects of deubiquitylating enzymes (DUB) inhibitors in HCC. It found that inhibitor ubiquitin specific peptidase 8 (USP8) DUB-IN-3 shows most effective anti-cancer responses. Targeting USP8 inhibits proliferation HCC induces cell ferroptosis. In vivo xenograft metastasis experiments indicate inhibition suppresses tumor growth lung metastasis. treatment or depletion decrease...
Abstract Hepatocellular carcinoma (HCC) is the most common type of primary hepatic carcinoma, which a growing public health problem worldwide. One main genetic alterations in HCC deregulated Wnt/β-catenin signaling, activation β-catenin associated with progression HCC. In present study, we aimed to identify novel modulators controlling ubiquitination and stability. USP8 was overexpressed tissues correlated protein level. High expression indicated poor prognosis patients. depletion...
Abstract Breast cancer is the most common malignancy for women worldwide, while Triple Negative Cancer (TNBC) accounts 20% in all patients. Compared with estrogen receptor positive breast cancer, which could be effectively controlled via endocrine therapy, TNBC more aggressive and worse prognosis. It therefore urgent necessary to develop a novel therapeutic strategy treatment. Recent studies identified Hippo signaling highly activated TNBC, driving pathway progression. In our study, we...
Breast cancer is the most commonly diagnosed malignancy in female worldwide, over 70% of which are estrogen receptor α (ERα) positive. ERα has a crucial role initiation and progression breast an indicator endocrine therapy, while resistance urgent problem ER-positive patients. In present study, we identify novel E3 ubiquitin ligase TRIM11 function to facilitate signaling. overexpressed human cancer, associates with poor prognosis. The protein level highly correlated ERα. RNA-seq results...
Breast cancer is the most common malignancy in women worldwide. Estrogen receptor α (ERα) expressed ∼70% of breast cases and promotes estrogen-dependent progression. In present study, we identified OTU domain-containing 7B (OTUD7B), a deubiquitylase belonging to A20 subgroup ovarian tumor protein superfamily, as bona fide ERα cancer. OTUD7B expression was found be positively correlated with associated poor prognosis. could interact with, deubiquitylate, stabilize deubiquitylation...
Histones methyltransferase NSD3 targeting H3K36 is frequently disordered and mutant in various cancers, while the function of during cancer initiation progression remains unclear. In this study, it proved that downregulated level linked to clinical features poor survival lung adenocarcinoma. vivo, inhibited proliferation, immigration, invasion ability Meanwhile, suppressed glycolysis by inhibiting HK2 translation, transcription, glucose uptake, lactate production Mechanistically, as an...
Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal human malignancies, with quite limited treatment alternatives. The proteasome responsible for protein degradation in eukaryotic cells required maintenance intracellular homeostasis. However, its potential role HCC largely unknown. In current study, we identified translation initiation factor 3 subunit H (EIF3H), belonging to JAB1/MPN/MOV34 (JAMM) superfamily, as a bona fide deubiquitylase O-GlcNAc transferase (OGT) HCC....
Anaplastic thyroid cancer (ATC) is one of the most aggressive and virulent solid tumors.The ubiquitin proteasome system presents in all eukaryotic cells essential for cellular homeostasis.While its underlying role ATC remains largely unclear.TRIM11 an E3 ligase has been reported to act as oncogene several human cancers.The present study aims reveal oncogenic function TRIM11 ATC.Western blot was used measure protein expression YAP, while YAP target genes were measured by real-time PCR.CCK8...
Anaplastic thyroid cancer (ATC) is one of the most lethal and aggressive human malignancies, with no effective treatment currently available. The Hippo tumor suppressor pathway highly conserved in mammals plays an important role carcinogenesis. TAZ major key effectors pathway. However, mechanism supporting abnormal expression ATC remains to be characterized. In present study, we identified USP26, a DUB enzyme ubiquitin-specific proteases family, as bona fide deubiquitylase ATC. USP26 was...
Oxaliplatin (OXA) resistance is a major clinic challenge in hepatocellular carcinoma (HCC). Ferroptosis kind of iron-dependent cell death. Triggering ferroptosis considered to restore sensitivity chemotherapy. In the present study, we found that USP20 was overexpressed OXA-resistant HCC cells. High expression associated with poor prognosis. contributes OXA and suppress HCC. Pharmacological inhibition or knockdown triggered increased cells both vitro vivo. Coimmunoprecipitation results...
Abstract Background Bladder cancer is one of the most commonly diagnosed urological malignant tumor. The Hippo tumor suppressor pathway highly conserved in mammals and plays an important role carcinogenesis. YAP major key effectors pathway. However, mechanism supporting abnormal expression bladder remains to be characterized. Methods Western blot was used measure MINDY1 YAP, while target genes were measured by real-time PCR. CCK8 assay detect cell viability. xeno-graft model for vivo study....
Abstract Breast cancer is one of the most frequently diagnosed malignancies and a leading cause death among females. Multiple molecular alterations are observed in breast cancer. LncRNA transcripts were proved to play important roles biology tumorigenesis. In this study, we aimed identify lncRNA expression signature that can predict patient survival. We developed 10‐lncRNA signature‐based risk score which was used separate patients into high‐risk low‐risk groups. Patients group had...
Breast cancer (BC) is the most common female malignancy worldwide, and 70% of which are estrogen receptor α (ERα) positive. Endocrine treatment, such as tamoxifen, a primary adjuvant therapy for patients with ER-positive BC. However, some will develop acquired resistance following long-time treatment. Further research on signaling important to improve these patients. In this study, we report that E3 ubiquitin ligase tripartite motif 8 (TRIM8) acts novel regulator ERα signaling. TRIM8...
Abstract Breast cancer is the most commonly diagnosed malignant tumor among females. Estrogen receptor α (ERα) initially expressed in 70% of breast cancers and a well-known target endocrine therapy for ERα-positive cancer. In present study, we identified MINDY1, member belongs to motif interacting with Ubcontaining novel DUB family (MINDY), as potential deubiquitylase ERα There was positive correlation between MINDY1 protein levels human tissues. We found that high expression associated poor...
Abstract Quite a few estrogen receptor (ER)‐positive breast cancer patients receiving endocrine therapy are at risk of disease recurrence and death. ER‐related genes involved in the progression chemoresistance cancer. In this study, we identified an gene signature that can predict prognosis ER‐positive patient therapy. We collected RNA expression profiling from Gene Expression Omnibus database. An was developed to separate into high‐risk low‐risk groups. Patients group had significantly...
Breast cancer is a malignancy with the highest incidence and mortality in women worldwide. Senescence model of arrest cell cycle, which plays an important role tumor progression, while prognostic value cellular senescence-related genes (SRGs) evaluating immune infiltration clinical outcomes breast needs further investigation. In present study, we identified two distinct molecular subtypes according to expression profiles 278 SRGs. We explored dysregulated pathways between constructed...
Abstract Background Prostate cancer (PC) is the most common neoplasm and second leading cause of cancer-related deaths in men worldwide. The Hippo tumor suppressor pathway highly conserved mammals plays an important role carcinogenesis. YAP one major key effectors pathway. However, mechanism supporting abnormal expression PC remains to be characterized. Methods Western blot was used measure protein ATXN3 YAP, while target genes were measured by real-time PCR. CCK8 assay detect cell...
Abstract Background Accidentally removed parathyroid glands are still challenging in neck surgery, leading to hypoparathyroidism characterized with abnormally low levels of hormone. Parathyroid auto-transplantation is usually applied compensation. To improve the efficiency transplantation, we introduced a method by co-transplanting adipose-derived cells, including stromal vascular fractions (SVFs) and stem cells (ADSCs), investigated underlying molecular mechanisms involved transplantation...
Tryptophan metabolism is associated with tumorigenesis and tumor immune response in various cancers. Liver the main place where tryptophan catabolism performed. However, role of hepatocellular carcinoma (HCC) has not been well clarified. In present study, we described mutations 42 metabolism-related genes (TRPGs) HCC cohorts. Then, patients were distributed into two subtypes based on expression profiles TRPGs. The clinicopathological characteristics microenvironmental landscape profiled. We...
Breast cancer is a major cause of cancer-related morbidity and mortality in women. Estrogen receptor-positive breast accounts for roughly 70%-80% tumors, estrogen receptor alpha (ERα) has been considered as key driver promoting progression. In the present study, we identified USP37 novel modulator modulating ERα ubiquitination stability. The expression was upregulated ERα-positive correlated with protein level. High associated unfavorable prognosis. depletion resulted significantly decreased...