A5020626458- Orthopaedic implants and arthroplasty
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Bone fractures and treatments
- Ferroptosis and cancer prognosis
- Hip and Femur Fractures
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Bone Tumor Diagnosis and Treatments
- Total Knee Arthroplasty Outcomes
- Ubiquitin and proteasome pathways
- Spine and Intervertebral Disc Pathology
- Hip disorders and treatments
- Cancer-related Molecular Pathways
- Cardiac Valve Diseases and Treatments
- Plant Virus Research Studies
- Scoliosis diagnosis and treatment
- Cancer, Hypoxia, and Metabolism
- Plant Disease Resistance and Genetics
- MicroRNA in disease regulation
- Spinal Fractures and Fixation Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Orthopedic Infections and Treatments
- Anatomy and Medical Technology
- Hippo pathway signaling and YAP/TAZ
Central South University
2022-2025
Xiangya Hospital Central South University
2023-2024
South China University of Technology
2022-2024
Second Xiangya Hospital of Central South University
2023
Zaozhuang University
2019
Objective: Aryl hydrocarbon receptor (AhR) is a transcription factor. It reported that AhR associated with non-small cell lung cancer (NSCLC), but the mechanisms underlying this relationship remain unclear. Therefore, we investigated role of in NSCLC to elucidate mechanisms. Methods: We collected clinical samples and constructed overexpression knockdown lines investigate tumorigenicity vivo vitro. Furthermore, performed ferroptosis induction experiment chromatin immunoprecipitation...
Histones methyltransferase NSD3 targeting H3K36 is frequently disordered and mutant in various cancers, while the function of during cancer initiation progression remains unclear. In this study, it proved that downregulated level linked to clinical features poor survival lung adenocarcinoma. vivo, inhibited proliferation, immigration, invasion ability Meanwhile, suppressed glycolysis by inhibiting HK2 translation, transcription, glucose uptake, lactate production Mechanistically, as an...
Disulfidptosis is a novel form of programmed cell death that unveils promising avenues for the exploration tumor treatment modalities. Gastric cancer (GC) malignant characterized by high incidence and mortality rate. However, there has been no systematic study disulfidptosis-related long noncoding RNAs (DRLs) signature in GC patients.The lncRNA expression profiles containing 412 samples were acquired from Cancer Genome Atlas (TCGA) database. Differential analysis was performed alongside...
Background Hip replacement surgeries are increasing in demand, requiring rigorous improvements to a mature surgical protocol. Postoperative patient dissatisfaction mainly stems from postoperative complications resulting the inappropriate selection of prostheses meet needs each patient. This results prosthesis loosening, hospital-related fractures, and complex pain, which can all be attributed sizing. In this study, we aimed further explore intraoperative benefits incorporating computer-aided...
Background/Objectives: Ribosomal Protein Lateral Stalk Subunit P2 (RPLP2), an important ribosomal protein, is mainly involved in modulating protein synthesis and plays essential role the carcinogenesis of many cancers. However, its precise impact on diffuse large B-cell lymphoma (DLBCL) remains unknown. Methods: This study utilized siRNA to knock down RPLP2, aiming investigate DLBCL progression. RT-qPCR immunohistochemistry (IHC) were employed assess RPLP2 frataxin (FXN) expression levels...
The Regulator of Chromosome Condensation 2 (RCC2) is an important gene that regulates mitosis and cytoplasmic division in the cell cycle. Although there have been reported several individual tumors, integrative analysis RCC2 its clinical significance across diverse cancer types poorly elucidated. In this study, we performed bioinformatics analyses to profile expression landscape assess prognostic value pan-cancers. Correlations between tumor-infiltrating immune cells, tumor mutation burden...
Abstract Objective Segmental bone defect animal studies require stable fixation which is a continuous experimental challenge. Large models are comparable to the human bone, but with obvious drawbacks of housing and costs. Our study aims utilize CAD 3D printing in construction reproducible segmental mode. Methods CAD-aided printed surgical instruments were incorporated into model through preoperative emulation. 20 femurs divided either group using or control group. In Vitro time accuracy...
The increasing clinical occurrence of segmental bone defects is demanding constant improvements in transplantation to overcome issues limited resources, immune rejection and poor structural complement. This study aimed develop a personalized defect repair modality using 3D-printed tricalcium phosphate (β-TCP) grafts assess its osteogenic impacts femoral model beagles, as basis for studies application. Aβ-TCP scaffold was designed manufactured computer-aided design. A 3 cm established 27...
AP4M1 is a protein-coding gene that plays crucial role in transporter activity, recognition, and hereditary-associated diseases, but it's largely unknown cancers.The expression level of cancers was investigated by The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases, the correlation between hepatocellular carcinoma (HCC) clinicopathological parameters were analyzed. Univariate multifactorial COX regression analyses performed to clarify prognostic value HCC. immune cell...
Objective To evaluate the feasibility and utility of computer‐aided design (CAD) in surgical treatment leg length discrepancy (LLD) using monorail external fixators. Methods In present case series, we retrospectively analyzed seven patients diagnosed with LLD who were surgically treated a fixator between June 2018 August 2020. A personalized emulation each patient was designed CAD based on preoperative CT scans to measure limb parameters. Through reverse engineering, guide plate then assist...
Rice black-streaked dwarf virus (RBSDV) and Southern rice (SRBSDV) seriously interfered in the production of maize China. These two viruses are members genus Fijivirus family Reoviridae can cause similar symptoms rice. Although some studies have reported phylogenetic analysis on RBSDV or SRBSDV, evolutionary relationship between these is scarce. In this study, we analyzed relationships SRBSDV based data from codon usage, RNA recombination relationship, selection pressure genetic...
<title>Abstract</title> <bold>Background:</bold>Total hip arthroplasty effectively treats developmental dysplasia of the hip. Severe acetabular deformities present challenges for accurate positioning and prosthetic placement. The advent three-dimensional printing offers a solution.The aim this study was to investigate clinical efficacy 3D printed surgical guides in total dysplasia. <bold>Patients Methods:</bold> A retrospective case-control conducted on patients treated between 2020 2023....
Abstract Objective: Introduction and Evaluation of the Effects 3D Technology-Assisted Transforaminal Spinal Osteotomy on Orthopedic Rate, Nail Placement Accuracy, Healing Methods: This study conducted a retrospective review treatment outcomes seven patients (four males three females), aged 19-59 years, who underwent transforaminal osteotomy between December 2011 March 2023. Digital Computer-Aided Design (CAD) technology was utilized for preoperative surgical planning precise intraoperative...
The trochanter of the femur is a common site for bone tumors. However, locating specific boundary tumor infiltration and determining surgical method can be challenging. objective this study was to review diagnosis, treatment, outcomes patients with tumors or tumor-like changes in femoral after computer-assisted precise resection hip-preserving reconstruction trochanter. From January 2005 September 2020 11 trochanteric (age: 18–53 years; six males five females) were treated at our...