A5021533737- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- RNA Interference and Gene Delivery
- Structural Response to Dynamic Loads
- Hip and Femur Fractures
- Structural Behavior of Reinforced Concrete
- Transportation Safety and Impact Analysis
- Dental Implant Techniques and Outcomes
- 3D Printing in Biomedical Research
- Bone fractures and treatments
- Nanoparticle-Based Drug Delivery
South China University of Technology
2021-2024
National Medical Products Administration
2023
Bone bionics and structural engineering have sparked a broad interest in optimizing artificial scaffolds for better bone regeneration. However, the mechanism behind scaffold pore morphology-regulated regeneration remains unclear, making structure design of repair challenging. To address this issue, we carefully assessed diverse cell behaviors mesenchymal stem cells (BMSCs) on β-tricalcium phosphate (β-TCP) with three representative morphologies (i.e., cross column, diamond, gyroid unit,...
The regenerative repair of large bone defects is a major problem in orthopedics and clinical medicine. key the lack ability existing graft materials to promote osteogenesis angiogenesis. Previous studies have shown that osteogenic or angiogenic abilities these could be significantly improved by adding miRNA small-molecule drugs materials; however, synergistic effect arising from this combination not clear. Therefore, we proposed construct dual drug delivery system simultaneously achieve...
The increasing clinical occurrence of segmental bone defects is demanding constant improvements in transplantation to overcome issues limited resources, immune rejection and poor structural complement. This study aimed develop a personalized defect repair modality using 3D-printed tricalcium phosphate (β-TCP) grafts assess its osteogenic impacts femoral model beagles, as basis for studies application. Aβ-TCP scaffold was designed manufactured computer-aided design. A 3 cm established 27...
Mechanical metamaterials feature specially designed structures that enhance their mechanical properties. A 3D-printed lattice material (LM) is a typical metamaterial with high strength, low weight, and considerable potential for application in bone implants, aircraft, automotive industries. Nevertheless, its limited owing to the difficulty of balancing specific strength toughness or fatigue resistance, which makes designing challenging. Inspired by excellent performance service life Zhaozhou...