A5022877958- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Genital Health and Disease
- Urologic and reproductive health conditions
- Ferroptosis and cancer prognosis
- Kidney Stones and Urolithiasis Treatments
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Tissue Engineering and Regenerative Medicine
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Dialysis and Renal Disease Management
- RNA modifications and cancer
- Ureteral procedures and complications
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- Sexual function and dysfunction studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Urinary Bladder and Prostate Research
- Pediatric Urology and Nephrology Studies
Central South University
2012-2024
Xiangya Hospital Central South University
2012-2024
Bladder cancer is the ninth most diagnosed in world. This study aims to investigate role and mechanisms of taurine-upregulated gene 1 (TUG1)/miR-140-3p/annexin A8 (ANXA8) axis bladder cancer. Western blotting qRT-PCR determined expression levels ANXA8, miR-140-3p, TUG1, epithelial-mesenchymal transition (EMT) markers. RNA immunoprecipitation (RIP), luciferase assay, pull-down assay validated association among TUG1. The biological functions were by colony formation, Annexin V-fluorescein...
To prospectively study the surgical strategies and clinical efficacy of laparoendoscopic single-site (LESS) inguinal lymphadenectomy compared with conventional endoscopic for management nodes.A total 12 patients squamous cell carcinoma penis who underwent penectomy between February July 2013 were enrolled in study. All bilateral (LESS one limb other) preservation saphenous vein. lymphatic tissue boundaries adductor longus muscle (medially), sartorius (laterally), 2 cm above ligament...
Abstract Background Prostate cancer (PC) is the most common neoplasm and second leading cause of cancer-related deaths in men worldwide. The Hippo tumor suppressor pathway highly conserved mammals plays an important role carcinogenesis. YAP one major key effectors pathway. However, mechanism supporting abnormal expression PC remains to be characterized. Methods Western blot was used measure protein ATXN3 YAP, while target genes were measured by real-time PCR. CCK8 assay detect cell...
Bladder cancer (BLCA) is featured with high incidence and mortality. Whether the IFN-γ signaling could be used as an immunotherapy determinant for BLCA has not been fully confirmed. In this study, transcriptome data clinical information of samples were collected from The Cancer Genome Atlas (TCGA). Besides, four cohorts including IMvigor210 cohort, Gide Van Allen Lauss cohort collected. Xiangya real-world was independent validation. An IFN-γ-related signature developed validated in...
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES STUDY ADD?: Bladder cancer (BC) is a public health problem throughout the world, and now radical cystectomy (RC) has been introduced as standard treatment for BC invading muscle some BCs not muscle. Pelvic lymph node dissection (PLND) considered an integral part of RC its prognostic therapeutic significance, but extent PLND precisely defined. Computed tomography one most preferable methods to assess stage preoperatively because high sensitivity...
Complex interactions in the tumor microenvironment (TME) between bladder cancer (BLCA) and immune cells are critical for progression. However, studies of neutrophil extracellular trap-associated long non-coding RNAs (NET-lncRNAs) TME BLCA have not been reported. This study aims to screen NET-lncRNAs preliminarily explore their effects on development.The correlation NET-related gene sets, which were identified from genome atlas (TCGA) datasets, with lncRNAs was analyzed prognosis-related...
Although enhancer of zeste homolog 2 (EZH2) has been reported as an independent prognostic factor in renal cell carcinoma (RCC), little is known about the exact mechanism EZH2 promoting genesis RCC. However, several studies have shown that dysregulation Wnt/β-catenin signaling pathway plays a crucial role. Therefore, we determined whether could affect ACHN human RCC proliferation and invasion via pathway. In present study, investigated effects short interfering RNA (siRNA)-mediated gene...
Bladder cancer (BC) is one of the most prevalent and life-threatening cancers among male population worldwide. Sex determining region Y-box protein 5 (SOX5) plays important roles in a variety human cancers. However, little research has been conducted on function underlying mechanism SOX5 BC. In present study, we first reveal increased expression BC tissues vitro cells lines. Second, discover that inhibition inhibits cell growth migration but promotes apoptosis. Meanwhile, ectopic stimulates...
<b><i>Objective:</i></b> To elucidate the role of CXCR4 in metastasis bladder transitional cell carcinoma (BTCC) by examining expression BTCC tissue and its correlation with clinicopathological features. <b><i>Methods:</i></b> The was assessed tissues from 70 patients 18 normal controls, respectively, using immunohistochemistry. lymph node also examined determining lymphatic vessel density (LVD). <b><i>Results:</i></b>...
Background. Thioesterase superfamily member 6 (THEM6) has been implicated in the development and progression of various cancers. However, prior research emphasized on its regulatory role merely, we aim to investigate effect THEM6 gene immunological relationship with molecular subtype bladder cancer (BLCA). Methods. Through pan-cancer analysis, explored expression pattern using The Cancer Genome Atlas (TCGA) database. In addition, performed a correlation functions, including immunomodulators,...