A5101956588- Protein Tyrosine Phosphatases
- RNA modifications and cancer
- Chinese history and philosophy
- Cancer-related gene regulation
- Galectins and Cancer Biology
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- Spine and Intervertebral Disc Pathology
- Protein Kinase Regulation and GTPase Signaling
- Autophagy in Disease and Therapy
- Musculoskeletal pain and rehabilitation
- Genomics, phytochemicals, and oxidative stress
- Hemoglobinopathies and Related Disorders
- Cardiovascular Function and Risk Factors
- Extracellular vesicles in disease
- Urban Transport and Accessibility
- Spinal Cord Injury Research
- Health, Environment, Cognitive Aging
- Marine Sponges and Natural Products
- Chemotherapy-induced cardiotoxicity and mitigation
- Chromatin Remodeling and Cancer
- Cardiac Fibrosis and Remodeling
- Gout, Hyperuricemia, Uric Acid
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Mechanisms and Therapy
Affiliated Hospital of Jining Medical University
2024-2025
Jinan University
2023-2025
First Affiliated Hospital of GuangXi Medical University
2023-2024
Guangxi Medical University
2019-2024
Hebei University of Chinese Medicine
2024
Shandong University
2018-2023
Central South University
2023
Xiangya Hospital Central South University
2023
Qilu Hospital of Shandong University
2023
Chongqing University
2023
Hepatocellular carcinoma (HCC) is a lethal and aggressive human malignancy. The present study examins the anti-tumor effects of deubiquitylating enzymes (DUB) inhibitors in HCC. It found that inhibitor ubiquitin specific peptidase 8 (USP8) DUB-IN-3 shows most effective anti-cancer responses. Targeting USP8 inhibits proliferation HCC induces cell ferroptosis. In vivo xenograft metastasis experiments indicate inhibition suppresses tumor growth lung metastasis. treatment or depletion decrease...
Abstract Hepatocellular carcinoma (HCC) is the most common type of primary hepatic carcinoma, which a growing public health problem worldwide. One main genetic alterations in HCC deregulated Wnt/β-catenin signaling, activation β-catenin associated with progression HCC. In present study, we aimed to identify novel modulators controlling ubiquitination and stability. USP8 was overexpressed tissues correlated protein level. High expression indicated poor prognosis patients. depletion...
Reactive oxygen species (ROS), predominantly generated by mitochondria, play a crucial role in the pathogenesis of intervertebral disc degeneration (IVDD). Reduction ROS levels may be an effective strategy to delay IVDD. In this study, we assessed whether umbilical cord mesenchymal stem cell-exosomes (UCMSC-exos) can used treat IVDD suppressing production caused mitochondrial dysfunction. Human UCMSC-exos were isolated and identified. Nucleus pulposus cells (NPCs) stimulated with H2O2...
Oxaliplatin (OXA) resistance is a major clinic challenge in hepatocellular carcinoma (HCC). Ferroptosis kind of iron-dependent cell death. Triggering ferroptosis considered to restore sensitivity chemotherapy. In the present study, we found that USP20 was overexpressed OXA-resistant HCC cells. High expression associated with poor prognosis. contributes OXA and suppress HCC. Pharmacological inhibition or knockdown triggered increased cells both vitro vivo. Coimmunoprecipitation results...
Resistance to chemotherapy is a major obstacle in the treatment of wide array different types cancer. Chemotherapeutic drug resistance achieved by cancer cells variety mechanisms, which can be either compound specific or general. An emerging mechanism for nonspecific chemotherapeutic relies on hyperactivity transcription factor Nrf2. Normally Nrf2 levels are tightly regulated ubiquitin-proteasome system; however, mutations genes responsible this regulation common many types, resulting...
Lignans are a powerful weapon for plants to resist stresses and have diverse bioactive functions protect human health. Elucidating the mechanisms of stereoselective biosynthesis response lignans is important guidance plant improvement. Here, we identified complete pathway stereoselectively synthesize antiviral (–)-lariciresinol glucosides in Isatis indigotica roots, which consists three-step sequential enzymes DIR1/2, PLR, UGT71B2. DIR1 was further as key gene able trigger stress defenses by...
Quorum sensing (QS) plays a critical role in the regulation of bacterial pathogenesis. Doscadenamide A (
Accurate protein structure in the ligand-bound state is a prerequisite for successful structure-based virtual screening (SBVS). Therefore, applications of SBVS against targets which only an apo available may be severely limited. To address this constraint, we developed computational strategy to explore target protein, by combined use molecular dynamics simulation, MM/GBSA binding energy calculation, and fragment-centric topographical mapping. Our validated low-molecular weight tyrosine...
The nucleus pulposus (NP) plays a vital role in intervertebral disc degeneration (IVDD). Previous studies have revealed cellular heterogeneity NP tissue during IVDD progression. However, the and molecular alterations of diverse cell clusters remain to be fully elucidated. tissues were isolated from patients with different grades undergoing discectomy, then subjected single-cell RNA sequencing (scRNA-seq). Cell subsets identified based on unbiased clustering gene expression profiles. Gene...