A5101827228- Advanced DC-DC Converters
- Multilevel Inverters and Converters
- Dermatology and Skin Diseases
- Microgrid Control and Optimization
- IL-33, ST2, and ILC Pathways
- Vascular Malformations and Hemangiomas
- Electromagnetic Compatibility and Noise Suppression
- Inflammatory mediators and NSAID effects
- Vascular Malformations Diagnosis and Treatment
- Advanced Glycation End Products research
- Advanced Battery Technologies Research
- Semiconductor Quantum Structures and Devices
- Silicon Carbide Semiconductor Technologies
- Hedgehog Signaling Pathway Studies
- Semiconductor materials and devices
- Vascular Anomalies and Treatments
- Cancer and Skin Lesions
- Allergic Rhinitis and Sensitization
- Induction Heating and Inverter Technology
- Psoriasis: Treatment and Pathogenesis
- Pediatric health and respiratory diseases
- Nonmelanoma Skin Cancer Studies
- Wound Healing and Treatments
- Synthesis of Organic Compounds
- Asthma and respiratory diseases
Ehime University
2015-2024
Nagasaki Medical Center
2011-2022
Universal Entertainment (Japan)
2021
Niigata Prefectural Shibata Hospital
2021
Ehime University Hospital
2020
University of Ottawa
2020
Sony Computer Science Laboratories
2020
San-ikukai Hospital
2019
Mukogawa Women's University
2011-2018
Osaka University
1965-2013
Abstract Trehalose is the nonreducing disaccharide of glucose, evolutionarily conserved in invertebrates. The living skin equivalent (LSE) an organotypic coculture containing keratinocytes cultivated on fibroblast-populated dermal substitutes. We demonstrated that human primary fibroblasts treated with highly concentrated trehalose promote significantly extensive spread epidermal layer LSE without any deleterious effects. RNA-seq analysis trehalose-treated 2D and 3D at early time points...
Modifying effects of a fungal product, flavoglaucin, and four plant-derived chemicals, shikonin, gingerol, oleanolic acid paeoniflorin, on intestinal carcinogenesis were examined in rat model using azoxymethane (AOM). A total 280 male F344 rats, 6 weeks old, divided into 12 groups. Group 1 (30 rats) was given two subcutaneous injections 15 mg/kg AOM at the start experiment. Groups 2 rats), 3 (20 4 5 received test chemical (flavoglaucin, or respectively) diet concentration 0.02% for weeks,...
Abstract Melinjo ( Gnetum gnemon L.) seed extract MSE ) and its active ingredient gnetin C GC ), a resveratrol dimer, have been shown to possess broad spectrum of pharmacological activities. In this study, we investigated the antitumor activity using human murine tumor cell culture models in vitro. The was compared with trans ‐resveratrol t RV stilbenoid polyphenol. Our results show that at clinically achievable concentrations significantly inhibited proliferation pancreatic, prostate,...
Attenuation characteristics of portal vein thrombi on nonenhanced computed tomographic (CT) scans were assessed in 122 patients with proved thrombosis. Portal high attenuation found four hepatocellular carcinoma. From pathologic and radiologic studies, it was concluded that the caused by blood clots recent onset formed at tip tumor thrombus. Differentiation from choledocholithiasis, hematobilia, calcification could be easily made means ultrasonography (US). Although plain CT is usually...
Abstract IL‐22 induces STAT3 phosphorylation and mediates psoriasis‐related gene expression. However, the signaling mechanism leading from pSTAT3 to expression of these genes remains unclear. We focused on Bcl‐3, which is induced by activation In cultured human epidermal keratinocytes, increased was translocated nucleus with p50 via activation. The increases in CXCL8, S100As β‐defensin 2 mRNA caused were abolished siRNA against Bcl‐3. Although CCL20 also augmented IL‐22, knockdown Bcl‐3 its...
Various epidermal growth factor receptor (EGFR) ligands are highly expressed in the epidermis of psoriasis lesions, and abnormal EGFR activation appears to be involved pathogenesis psoriasis. However, how signaling contributes development is unclear. Interleukin (IL)-17A, a critical effector IL-23/IL-17A pathway, increases expression signature genes keratinocytes plays an essential role by inducing IκBζ, transcriptional regulator In this study, we stimulated primary human with IL-17A various...
Abstract Sweat is an essential protection system for the body, but its failure can result in pathologic conditions, including several skin diseases, such as palmoplantar pustulosis (PPP). As reduced intraepidermal E-cadherin expression lesions was confirmed PPP lesions, a role interleukin (IL)-1-rich sweat has been proposed, and IL-1 implicated altered observed both cultured keratinocytes mice epidermis. For further investigation, live imaging of perspiration on mouse toe-pad under...
Abstract Angiogenesis is a promising target for cancer prevention and treatment. This study aimed to determine the antiangiogenic effects of melinjo ( Gnetum gnemon L.) seed extract its resveratrol derivative components, such as gnetin C (GC), L (GL), gnemonoside A (GMA), (GMC), D (GMD). An ethanol seeds (EEMS) two gnetins markedly inhibited proliferation tube formation human umbilical vein endothelial cells (HUVEC) stimulated with vascular growth factor basic fibroblast factor. The...
Nuclear IL-33 levels are high at the epidermal edges of skin wounds and facilitate wound healing. However, IL-33-mediated regulation keratinocyte (KC) biology during healing remains poorly understood. During skin-wound healing, KC migration re-epithelialization mediated predominantly by EGFR signaling activation depend on function signal transducer activator transcription 3 (STAT3). We found that migrating KCs leading mouse exhibited concomitant induction nuclear colocalization...
The conventional boost converters are generally used for rectifier circuits with power factor correction, and as a result the output voltage becomes limited. To expand controlled range, buck-boost or Cuk converter types should be utilized. This paper presents circuit configuration correction by third type of buck converter, termed 'CSC, canonical switching cell'. Single-phase using can control over wide because it has ability to step-up step-down voltage. Firstly, this compares mechanisms...
Undoped GaAs epitaxial layers were grown by low-pressure MOCVD in a wide range of operating pressure (3×10 -3 to 75 Torr). These had smooth surfaces. Conductivity the under same [AsH 3 ]/[TMG] ratio (=75) changed from n-type p-type at about 5×10 -1 Torr as was reduced. Low temperature photoluminescence spectra indicate that carbon is dominant acceptor and its concentration increases
Various immune mediators are hypothesized to have important roles in the pathogenesis of vitreoretinal B-cell lymphoma, although exact mechanisms remain unclear. We determined mediator profile vitreous eyes with lymphoma.We studied 28 (23 patients) and 27 (27 undergoing vitrectomy for macular hole epiretinal membrane served as controls. Undiluted samples were collected, cytometric bead array ELISA used determine concentrations 38 mediators, including 14 interleukins (IL); interferon (IFN)-γ;...
Abstract The objective was to prepare guidelines perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas vascular malformations, confirming safety, systematizing treatment, employing evidence-based medicine (EBM) techniques aimed at improvement outcomes. Clinical questions (CQs) were decided based on important clinical issues. For document retrieval, key words for literature searches set each CQ published from 1980 end September 2014 searched in...
Abstract The objective was to prepare guidelines perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas vascular malformations, confirming safety, systematizing treatment, employing evidence‐based medicine (EBM) techniques aimed at improvement outcomes. Clinical questions (CQs) were decided based on important clinical issues. For document retrieval, key words for literature searches set each CQ published from 1980 end September 2014 searched in...
Abstract The objective was to prepare guidelines perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas vascular malformations, confirming safety systematizing treatment, employing evidence‐based medicine techniques aimed at improvement outcomes. Clinical questions (CQ) were decided based on important clinical issues. For document retrieval, key words for published work searches set each CQ, from 1980 end September 2014 searched in PubMed,...