A5068623243- Angiogenesis and VEGF in Cancer
- Zebrafish Biomedical Research Applications
- Cancer, Hypoxia, and Metabolism
- Apelin-related biomedical research
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Axon Guidance and Neuronal Signaling
- Epigenetics and DNA Methylation
- Lipid metabolism and disorders
- Mesenchymal stem cell research
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Nuclear Receptors and Signaling
- Biomarkers in Disease Mechanisms
- Acute Myeloid Leukemia Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hematopoietic Stem Cell Transplantation
- Lymphatic System and Diseases
- Immune cells in cancer
- Congenital heart defects research
- Phagocytosis and Immune Regulation
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- MicroRNA in disease regulation
- Fluorine in Organic Chemistry
Osaka University
2016-2025
Osaka International University
2019-2024
Shiga Medical Center for Children
2023
Osaka International Cancer Institute
2023
Takeda (Japan)
2017-2020
Japan Science and Technology Agency
2005-2015
Microbial Chemistry Research Foundation
2006-2015
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2014
Centre de Recherche Jean Pierre Aubert
2012
Toyoda Gosei (Japan)
2012
Cyclic AMP (cAMP) is a well-known intracellular signaling molecule improving barrier function in vascular endothelial cells. Here, we delineate novel cAMP-triggered signal that regulates the function. We found cAMP-elevating reagents, prostacyclin and forskolin, decreased cell permeability enhanced (VE) cadherin-dependent adhesion. Although increased VE-cadherin-mediated adhesion by forskolin were insensitive to specific inhibitor for cAMP-dependent protein kinase, these effects mimicked...
Preeclampsia is a relatively common pregnancy-related disorder. Both maternal and fetal lives will be endangered if it proceeds unabated. Recently, the placenta-derived anti-angiogenic factors, such as soluble fms-like tyrosine kinase-1 (sFLT1) endoglin (sENG), have attracted attention in progression of preeclampsia. Here, we established unique experimental model to test role sFLT1 preeclampsia using lentiviral vector-mediated placenta-specific expression system. The mice showed hypertension...
In gastrulating embryos, various types of cells are generated before differentiation into specific lineages. The mesoderm the mouse embryo represents a group such intermediate cells. PDGF receptor alpha (PDGFRα), c‐Kit and fetal liver kinase 1 (Flk1) expressed in distinctive mesodermal derivatives post‐gastrulation embryos. Their expressions during gastrulation were examined by whole mount immunostaining with monoclonal antibodies against these three receptors. stained different subsets Flow...
Abstract Cells constituting the tumor microenvironment are attractive targets for developing new cancer therapies. Here we show that cancer-associated fibroblasts (CAFs) support growth in vivo and maintain stemness of stem/initiating cells an vitro model using established CAF cell line. We found CD44 is abundantly expressed on CAFs. This molecule a stem marker several tumors, but its role tumorigenesis when by CAFs has not been investigated. It generally accepted hypoxic hyponutritional...
Sphingosine 1-phosphate (S1P) induces diverse biological responses in various tissues by activating specific G protein-coupled receptors (S1P<sub>1</sub>–S1P<sub>5</sub> receptors). The signaling regulated S1P<sub>3</sub> receptor has not been fully elucidated because of the lack an receptor-specific antagonist or agonist. We developed a novel antagonist, 1-(4-chlorophenylhydrazono)-1-(4-chlorophenylamino)-3,3-dimethyl- 2-butanone (TY-52156), and show here that S1P-induced decrease coronary...
In the central nervous system, endothelial cells (ECs) and pericytes (PCs) of blood vessel walls cooperatively form a physical chemical barrier to maintain neural homeostasis. However, in diabetic retinopathy (DR), loss PCs from is assumed cause breakdown blood-retina (BRB) subsequent vision-threatening vascular dysfunctions. Nonetheless, lack adequate DR animal models has precluded disease understanding drug discovery. Here, by using an anti-PDGFRβ antibody, we show that transient...
Heart failure, which is a major global health problem, often preceded by pathological cardiac hypertrophy. The expansion of the vasculature, to maintain adequate supply oxygen and nutrients, key determinant whether heart grows in physiological compensated manner or decompensated manner. Bidirectional endothelial cell (EC)-cardiomyocyte (CMC) cross talk via cardiokine angiocrine signaling plays an essential role regulation growth homeostasis. Currently, mechanisms involved EC-CMC interaction...