A5100768517- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Salivary Gland Tumors Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Inflammatory Myopathies and Dermatomyositis
- Atherosclerosis and Cardiovascular Diseases
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Gut microbiota and health
- Growth Hormone and Insulin-like Growth Factors
- Galectins and Cancer Biology
- Immunodeficiency and Autoimmune Disorders
- Oral Health Pathology and Treatment
- Eosinophilic Disorders and Syndromes
- IgG4-Related and Inflammatory Diseases
- Chronic Lymphocytic Leukemia Research
- Ocular Surface and Contact Lens
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Chemokine receptors and signaling
- Inflammasome and immune disorders
Peking University People's Hospital
2016-2025
Peking University
2016-2025
Guiyang Medical University
2024-2025
Harbin Medical University
2024
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
Affiliated Hospital of Guizhou Medical University
2024
Wuhan University
2022-2024
Renji Hospital
2024
Shanghai Jiao Tong University
2024
Objectives Open-labelled clinical trials suggested that low-dose IL-2 might be effective in treatment of systemic lupus erythematosus (SLE). A double-blind and placebo-controlled trial is required to formally evaluate the safety efficacy therapy. Methods randomised, was designed treat 60 patients with active SLE. These received either (n=30) or placebo standard for 12 weeks, were followed up additional weeks. at a dose 1 million IU administered subcutaneously every other day 2 weeks by...
The imbalance between pathogenic and beneficial species of the intestinal microbiome metabolism in rheumatoid arthritis (RA) remains unclarified. Here, using shotgun-based metagenome sequencing for a treatment-naïve patient cohort “quasi-paired cohort” method, we observed deficiency butyrate-producing an overwhelming number butyrate consumers RA patients. These outcomes mainly occurred patients with positive ACPA, mean AUC 0.94. This panel was also validated established 0.986 those joint...
Abstract Background Sjögren's syndrome (SS) is a chronic, systemic autoimmune disorder characterized by sicca and/or manifestations. The disease severely affects the health and life of patients, treatment SS has always been clinical challenge essentially palliative. Mesenchymal stem cells (MSCs) have reported to exert immunomodulatory effects as potential novel therapeutic strategy for SS. Labial gland-derived MSCs (LGMSCs) are population resident in labial gland, first isolated our group....
Abstract Rheumatoid arthritis (RA) is an aggressive autoimmune arthritis, and current therapies remain unsatisfactory due to low remission rate substantially adverse effects. Low-dose interleukin-2 (Ld-IL2) potentially a therapeutic approach further improve the disease. This randomized, double-blind, placebo-controlled trial was undertaken evaluate efficacy safety of Ld-IL2 in patients with active RA. Patients were randomly assigned (1:1) receive Ld-IL2, defined as dose 1 million IU, or...
Primary Sjögren syndrome (pSS) is a systemic autoimmune disease associated with dysregulated immune cells, no efficient therapy. There need to study potential therapeutic approaches.To investigate the efficacy, safety, and response of low-dose interleukin 2 (LD-IL-2) in treatment pSS.A double-blind, placebo-controlled randomized clinical trial was conducted 2-group superiority design from June 2015 August 2017. Sixty patients, aged 18 70 years, were recruited Peking University People's...
Abstract Patients with SLE are at high risk of various infections as evidenced by a number studies. The main determinants infection in disease activity, organ damage, and often inevitable medication. molecular cellular mechanisms underlying remain unclear. Impaired immunity, immunosuppressants corticosteroids clearly increase the infection, whereas some medications, such low-dose IL-2, hydroxychloroquine IVIG safe patients substantial evidence. It is important to balance immunosuppression...
B10 and B10pro cells suppress immune responses via secreting interleukin (IL)-10. However, their regulators underlying mechanisms, especially in human autoimmune diseases, are elusive. This study aimed to address these questions rheumatoid arthritis (RA), one of the most common highly disabling diseases.
Environmental factors play an important role in the development of rheumatoid arthritis (RA). Among these factors, smoking is generally considered to be established risk factor for RA. Data regarding impact diet on RA limited. This study assessed dietary patterns susceptibility Chinese populations. was a large scale, case-control composed 968 patients with and 1037 matched healthy controls. Subjects were recruited from 18 teaching hospitals. Socio-demographic characteristics intakes 5 years...
Objective: This study was conducted to identify the characteristics and prognosis of rapidly progressive interstitial lung disease (RP-ILD) in idiopathic inflammatory myopathy (IIM) assess predictors for poor survival RP-ILD IIM. Methods: A total 474 patients with IIM were enrolled retrospectively according medical records from Peking University People's Hospital. Clinical laboratory recorded at diagnosis chronic ILD (C-ILD) compared. The Kaplan-Meier estimator univariate multivariate...
The pathogenesis of the prototypical chronic autoimmune disorder primary Sjögren syndrome (pSS) has been thought to be B-cell-centric, based on serum autoantibodies, increased risk B cell lymphoma, and altered subsets in patients with pSS. Over last 10 years, therapies targeting cells have investigated for pSS; however, current evidence efficacy targeted pSS is still sparse. Mesenchymal stem (MSCs) might represent a promising strategy therapy diseases via regulation immune cells....
Antimelanoma differentiation-associated protein 5 (anti-MDA5) autoantibody has been reported in dermatomyositis (DM) to be associated with rapidly progressive interstitial lung disease (RP-ILD). Our study is aimed at determining the clinical characteristics and prognostic factors underpinning anti-MDA5-associated RP-ILD. Patients DM (aMDA5-DM) were identified Peking University People's Hospital. The presence of anti-MDA5 antibody was determined by immunoblotting. Kaplan-Meier, chi-square...
Objective: Recent studies on double negative B cells (DN cells) suggested that they have potential pathogenic roles in systemic lupus erythematosus (SLE). This study aimed to determine the circulating DN SLE patients and analyzed clinical significance of this cell subset. Methods: Fifty-seven fifty healthy controls (HCs) were recruited study. Among 57 patients, 25 had nephritis (LN). All followed up for 24 weeks. Peripheral subsets by flow cytometry. Results: significantly elevated...
Abstract Follicular helper T (T FH ) cells control antibody responses by supporting affinity maturation and memory formation. Inadequate function has been found in individuals with ineffective to vaccines, but the mechanism underlying regulation vaccination is not understood. Here, we report that lower serum levels of metabolic hormone leptin associate reduced vaccine influenza or hepatitis B virus vaccines healthy populations. Leptin promotes mouse human differentiation IL-21 production via...
Abstract We consider to model matrix time series based on a tensor canonical polyadic (CP)-decomposition. Instead of using an iterative algorithm which is the standard practice for estimating CP-decompositions, we propose new and one-pass estimation procedure generalized eigenanalysis constructed from serial dependence structure underlying process. To overcome intricacy solving rank-reduced eigenequation, further refined approach projects it into lower-dimensional full-ranked eigenequation....
Objective. To assess the diagnostic value of salivary gland ultrasonography (SGUS) for primary SS (pSS) and to compare usefulness two existing SGUS scoring systems.
An IgG1 SNP enhances autoimmunity One common feature of autoimmune diseases like systemic lupus erythematosus (SLE) is the presence high titers self-reactive antibodies. These result in immune complexes, inflammation, and tissue pathology. Consequently, checkpoints that normally keep immunoglobulin G (IgG)–positive autoreactive B cells check are intense interest. Chen et al. report a single-nucleotide polymorphism (SNP) East Asian populations (hIgG1-G396R). This was enriched SLE patients...
Primary Sjögren's syndrome (SS) is a lymphoproliferative disease with chronic autoimmune disorder characterized by mononuclear cell (MNC) infiltration of notably the lacrimal and salivary glands. As mesenchymal stem cells (MSCs) regulate series immunological responses partially regulating proportion CD4+ T inducing an immunosuppressive local milieu, umbilical cord MSCs (UC-MSCs) are being considered as novel source for cell-based therapies against primary SS. This study aimed to investigate...
Autoimmune diseases are often treated by glucocorticoids and immunosuppressive drugs that could increase the risk for infection, which in turn deteriorate disease cause mortality. Low-dose IL-2 (Ld-IL2) therapy emerges as a new treatment wide range of autoimmune diseases. To examine its influence on we retrospectively studied 665 patients with systemic lupus erythematosus (SLE) including about one third receiving Ld-IL2 therapy, where was found beneficial reducing incidence infections. In...