A5048373926- Pancreatitis Pathology and Treatment
- Nutrition and Health in Aging
- Endometrial and Cervical Cancer Treatments
- Health disparities and outcomes
- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Ovarian cancer diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Mitochondrial Function and Pathology
- Venous Thromboembolism Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Cardiovascular Health and Risk Factors
- Abdominal vascular conditions and treatments
- Blood Pressure and Hypertension Studies
- Gallbladder and Bile Duct Disorders
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Workplace Health and Well-being
- Neurological Disease Mechanisms and Treatments
- Organ Transplantation Techniques and Outcomes
- Intraperitoneal and Appendiceal Malignancies
Air Force Medical University
2021-2025
Chongqing Medical University
2016-2024
Siemens (China)
2024
Huazhong University of Science and Technology
2024
China Medical University
2024
First Hospital of Jilin University
2024
Jilin University
2012-2024
Chinese PLA General Hospital
2014-2023
Xinjiang Police College
2023
Case Western Reserve University
2023
Abstract Treatment of depression with antidepressants is partly effective. Transcranial alternating current stimulation can provide a non-pharmacological alternative for adult patients major depressive disorder. However, no study has used the to treat first-episode and drug-naïve We randomized, double-blind, sham-controlled design examine clinical efficacy safety in treating Chinese Han population. From 4 June 2018 30 December 2019, 100 were recruited randomly assigned receive 20 daily...
Abstract Purpose: Previous poor results of liver transplantation (LT) have been confirmed in patients with advanced hepatocellular carcinoma (HCC). Adenovirus-mediated delivery herpes simplex virus thymidine kinase (ADV-TK) therapy is an established adjuvant treatment cancer, and we evaluated its potential as for HCC who underwent LT. Experimental Design: Forty-five tumors >5 cm diameter participated the study over a follow-up period 50 months. Among these patients, 22 received LT...
Although elevated levels of homocysteine (Hcy) are associated with cognitive impairment and dementia, the relevance Hcy, vitamin B12, folate to subtypes dementia still unknown.To investigate changes in mild (MCI) including Alzheimer's disease (AD), vascular (VaD), frontotemporal (FTD), Lewy body (LBD), their relationships function magnetic resonance imaging (MRI) markers.We measured serum 257 subjects. Each subject underwent assessment brain MRI test. The Fazekas temporal lobe atrophy (MTA)...
194 Background: Colorectal cancer (CRC) is increasingly prevalent in China, with rising incidence and mortality rates. Often, early-stage CRC presents no symptoms, leading to most patients being diagnosed at an advanced stage, where prognosis poor. First- second-line treatments for typically include chemotherapy combined cetuximab or bevacizumab. However, third-line therapies such as regorafenib, furosemide, TAS102 have shown limited efficacy. Anlotinib, a multi-targeted tyrosine kinase...
Background Peptic ulcer disease (PUD) constitutes a significant global health concern, particularly in women of childbearing age (WCBA), who face elevated risks severe pregnancy-associated complications. This investigation aimed to map the temporal dynamics and forecast future incidence PUD this demographic inform targeted prevention control initiatives. Methods analysis drew on Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2021, extracting data mortality across seven groups...
Background: As evidence on depression and health-related quality of life (HRQoL) among the oldest-old is currently limited, this study aimed to re-examine association between HRQoL centenarians. Methods: We analyzed cross-sectional data from China Hainan Centenarian Cohort Study (CHCCS). The 15-item Geriatric Depression Scale (GDS-15) EuroQol five dimensions-visual analog scale (EQ-5D-VAS) were used evaluate HRQoL, respectively. Poor health states defined as EQ-5D index<0.665. Based their...
Abstract Background: Gallbladder and biliary tract cancer (GBTC) has greatly damaged the health of patients is accompanied by a dismal prognosis. The worldwide distribution GBTC shows extensive variance updated data in China lacking. This study was to determine current status, trends, predictions burden over past 30 years China. Methods: descriptive, epidemiological, secondary analysis Global Burden Disease, Injuries, Risk Factor Study 2019 data. Data including incidence, prevalence,...
remaining 4 patients dramatically responded to steroid therapy.No pancreatic cancer occurred during a mean 46-mo follow-up period.CONCLUSION: AIP always are subjected mistaken diagnosis of and an unnecessary surgical exploration, due its similarity in clinical features with cancer.The differential high index suspicion would improve the diagnostic accuracy for AIP.
Cyclins are essential for cell proliferation, the cycle and tumorigenesis in all eukaryotes. UbcH10 regulates degradation of cyclins a ubiquitin-dependent manner. Here, we report that is likely involved tumorigenesis. We found cancer cells exposed to n-acetyl-leu-leu-norleucinal (ALLN) treatment depletion exhibit synergistic therapeutic effect. Abundant expression drives resistance ALLN-induced death, while deficient were susceptible death. The hindered both vitro vivo, as assessed by colony...
Aeromonas caviae (A. caviae) is one of the major etiological agents in human intestinal infections reported to be associated with a broad spectrum extra-intestinal increasing incidence over recent years. Although previous studies have established its significance as causative agent both bloodstream and gastrointestinal infections, characteristics A. that cause remain unilluminated.In this single-center retrospective study, we investigated epidemiological characteristics, antimicrobial...
This study aimed to analyse the effects of servant leadership on nurses' emotional failure and compliance with standard precautions explore moderating effect individual resilience.
Accumulating evidence suggests that cardiovascular diseases and breast cancer share a number of common risk factors, however, on the association between health (CVH) is limited. The present study aimed to assess CVH, defined by Life's Essential 8 (LE8) genetic with incidence mortality among premenopausal postmenopausal women.
The neoadjuvant therapy has significantly improved the outcome of locally advanced resectable T3 rectal cancer patients. Actually, only a portion patients show sensitivity to preoperative chemoradiation and benefit markedly from this treatment. However, biomarkers for predicting remain unclear. In study, through screening series microRNAs dysregulated in colorectal patients, we observed that miRNA-497 expression was downregulated tumor tissues chemotherapy responders as compared...
Helicobacter pylori infection is recognized as a major risk factor for gastric cancer (GC) progression; however, the underlying molecular mechanisms have remained to be fully elucidated.qPCR and Western blot were used detect mRNA level relative protein expression. Wound healing assay transwell determine migration invasion of cells. Calcium imaging was calcium signaling in Luciferase reporter immunohistochemistry performed.In present study, it demonstrated that H. GC closely associated with...
Objective: To evaluate the combined effects of anemia and cognitive function on risk all-cause mortality in oldest-old individuals. Design: Prospective population-based cohort study. Setting Participants: We included 1,212 individuals (men, 416; mean age, 93.3 years). Methods: Blood tests, physical examinations, health questionnaire surveys were conducted 2012 used for baseline data. Mortality was assessed subsequent 2014 2018 survey waves. Cox proportional hazards models to anemia,...
Multimorbidity presents an enormous problem to societal and healthcare utilization under the context of aging population in low- middle-income countries (LMICs). Currently, systematic studies on profile multimorbidity its characteristics among Chinese elderly are lacking. We described temporal spatial trends prevalence explored chronological changes comorbidity patterns a large survey.Data were extracted from Longitudinal Healthy Longevity Study (CLHLS) conducted between 1998 2018 random...
Pancreatitis is a common disease of the digestive system. Acute pancreatitis one most reasons for gastrointestinal hospital admission, and chronic significantly reduces quality life. However, national epidemiological data on in China are lacking. This study aimed to quantify burden from 1990 2019.This was based Global Burden Disease Study 2019 dataset. Age-standardized rates incidence (ASIR), prevalence (ASPR), mortality (ASMR), disability-adjusted life years (DALYs) were used describe...
Abstract To search for an association between sepsis and mitochondrial genetic basis, we began our study. In this study, a proband harbouring T6459C mutation with his Chinese Han pedigree including 7 members of 3 generations were enrolled. General information, blood parameters full sequence scanning all performed, cellular functions, reactive oxygen species ( ROS ) levels, membrane potential MMP ), degrees cell apoptosis adenosine triphosphate ATP concentrations, measured in without the...
Background: The optimal treatment strategy for elderly patients with early gastric adenocarcinoma (EGAC) after non-curative endoscopic submucosal dissection (ESD) remains unclear. purpose of this research was to explore the effectiveness additional treatments ESD and factors affecting survival in (≥60 years age) EGAC. Methods: A total 639 years) treated EGAC from 2006 2018 were retrospectively reviewed. Positive lymphatic infiltration, positive/indeterminate vertical resection margins are...
Objective This study was performed to determine the risk factors associated with peripherally inserted central catheter (PICC)-related venous thrombosis in patients of advanced age (>65 years). Methods In total, 549 hospitalized aged 66 104 years who were undergoing PICC placement from January 2008 December 2014 enrolled. Symptomatic confirmed by B-mode or Doppler ultrasonography presence clinical signs. Logistic regression analysis on variables interest identify for thrombosis. Odds...