A5041468292- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Hepatitis C virus research
- Dialysis and Renal Disease Management
- Hepatitis B Virus Studies
- Gout, Hyperuricemia, Uric Acid
- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Ferroptosis and cancer prognosis
- Acute Kidney Injury Research
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Acute Ischemic Stroke Management
- Potassium and Related Disorders
- Bartonella species infections research
- Atherosclerosis and Cardiovascular Diseases
- Gastroesophageal reflux and treatments
- Liver physiology and pathology
- Rabies epidemiology and control
- Viral Infections and Vectors
- COVID-19 and healthcare impacts
- Vasculitis and related conditions
- Viral Infections and Immunology Research
Nanfang Hospital
2011-2025
Southern Medical University
2011-2025
Xinjiang Production and Construction Corps
2024-2025
Shihezi University
2015-2025
Lanzhou University
2023-2025
Chongqing Cancer Hospital
2024-2025
Chongqing University
2024-2025
Anhui University of Traditional Chinese Medicine
2019-2025
Washington University in St. Louis
2014-2024
Guangdong Medical College
2017-2024
The last quarter century witnessed significant population growth, aging, and major changes in epidemiologic trends, which may have shaped the state of chronic kidney disease (CKD) epidemiology. Here, we used Global Burden Disease study data methodologies to describe change burden CKD from 1990 2016 involving incidence, prevalence, death, disability-adjusted-life-years (DALYs). Globally, incidence increased by 89% 21,328,972 (uncertainty interval 19,100,079– 23,599,380), prevalence 87%...
B-cell anomalies play a role in the pathogenesis of membranous nephropathy. depletion with rituximab may therefore be noninferior to treatment cyclosporine for inducing and maintaining complete or partial remission proteinuria patients this condition.We randomly assigned who had nephropathy, at least 5 g per 24 hours, quantified creatinine clearance 40 ml minute 1.73 m2 body-surface area been receiving angiotensin-system blockade 3 months receive intravenous (two infusions, 1000 mg each,...
BackgroundPM2·5 air pollution is associated with increased risk of diabetes; however, a knowledge gap exists to further define and quantify the burden diabetes attributable PM2·5 pollution. Therefore, we aimed relationship between diabetes. We also characterise an integrated exposure response function provide quantitative estimate global national PM2·5.MethodsWe did longitudinal cohort study association built US veterans no previous history from various databases. Participants were followed...
The association between proton pump inhibitors (PPI) use and risk of acute interstitial nephritis has been described. However, whether exposure to PPI associates with incident CKD, CKD progression, or ESRD is not known. We used Department Veterans Affairs national databases build a primary cohort new users (n=173,321) histamine H2-receptor antagonists (H2 blockers; n=20,270) followed these patients over 5 years ascertain renal outcomes. In adjusted Cox survival models, the group, compared H2...
Elevated levels of fine particulate matter <2.5 µ m in aerodynamic diameter (PM 2.5 ) are associated with increased risk cardiovascular outcomes and death, but their association CKD ESRD is unknown. We linked the Environmental Protection Agency Department Veterans Affairs databases to build an observational cohort 2,482,737 United States veterans, used survival models evaluate PM concentrations incident eGFR <60 ml/min per 1.73 2 , CKD, decline ≥30%, over a median follow-up 8.52 years....
The increasing emergence and dissemination of multidrug resistant (MDR) bacterial pathogens accelerate the desires for new antibiotics. Natural products dominate preferred chemical scaffolds discovery antibacterial agents. Here, potential natural flavonoids from plants against MDR bacteria, is demonstrated. Structure-activity relationship analysis shows prenylation modulates activity obtains two compounds, α-mangostin (AMG) isobavachalcone (IBC). AMG IBC not only display rapid bactericidal...
Objective Proton pump inhibitors (PPIs) are widely used, and their use is associated with increased risk of adverse events. However, whether PPI excess death unknown. We aimed to examine the association between all-cause mortality. Design Longitudinal observational cohort study. Setting US Department Veterans Affairs. Participants Primary new users or histamine H2 receptor antagonists (H2 blockers) (n=349 312); additional cohorts included versus no (n=3 288 092) blockers (n=2 887 030). Main...
Abstract Objective To estimate all cause mortality and specific among patients taking proton pump inhibitors (PPIs). Design Longitudinal observational cohort study. Setting US Department of Veterans Affairs. Participants New users PPIs (n=157 625) or H2 blockers (n=56 842). Main outcome measures All associated with (values reported as number attributable deaths per 1000 PPIs). Results There were 45.20 excess (95% confidence interval 28.20 to 61.40) PPIs. Circulatory system diseases (number...
Proton pump inhibitor (PPI) use is associated with an increased risk of acute kidney injury (AKI), incident chronic disease (CKD), and progression to end-stage renal (ESRD). PPI-associated CKD presumed be mediated by intervening AKI. However, whether PPI outcomes in the absence AKI unknown. To evaluate this we used Department Veterans Affairs national databases build a cohort 144,032 users acid suppression therapy that included 125,596 18,436 Histamine H2 receptor antagonist (H2 blockers)...
Experimental evidence suggests that higher levels of urea may increase insulin resistance and suppress secretion. However, whether blood nitrogen (BUN) are associated with increased risk incident diabetes mellitus in humans is not known. To study this, we built a national cohort 1,337,452 United States Veterans without to characterize the association BUN diabetes. Over median follow-up 4.93 years, there were 172,913 cases In joint models estimated glomerular filtration rate (eGFR) BUN. was...
Experimental evidence and preliminary clinical suggest that environmental air pollution adversely effects kidney health. Previous work has examined the association between fine particulate matter risk of disease; however, ambient coarse (PM10; ≤10 μm in aerodynamic diameter), nitrogen dioxide (NO2), carbon monoxide (CO) incident chronic disease, disease progression, end-stage renal is not clear.We merged multiple large databases, including those Environmental Protection Agency Department...
<h3>Introduction</h3> Over the past 15 years, changes in demographic, social, and epidemiologic trends occurred United States. These likely contributed to chronic kidney disease (CKD) epidemiology. <h3>Objective</h3> To describe change burden of CKD at US state level from 2002 2016. <h3>Design, Setting, Participants</h3> This systematic analysis used data methodologies 2016 Global Burden Disease study Data on were examined level. <h3>Main Outcomes Measures</h3> Disability-adjusted life years...
<h3>Importance</h3> Lower extremity amputation (LEA) is associated with significant morbidity and mortality. However, national temporal trends of LEA incidence rates among US veterans factors have not been well characterized. <h3>Objective</h3> To describe the LEA, characterize risk factors, decompose associations these changes in using Department Veteran Affairs (VA) services between 2008 2018. <h3>Design, Setting, Participants</h3> This cohort study used VA data from to 2018 estimate...
Enhanced neuroinflammation is an important mechanism underlying perioperative neurocognitive disorders. Regulatory T cells (Tregs) play a crucial role in regulating systemic immune responses. The present study was aimed to investigate the participation of Tregs development postoperative cognitive dysfunction (POCD).Surgery-associated disorder induced 18-month-old mice subjected internal fixation tibial fracture. Morris water maze used examine function. Splenic were collected for RNA...
Fractalkine, a chemokine binding to only one known receptor CX3CR1, has recently been proposed be neuron-to-glia signal in the spinal cord leading microglial activation and glially dependent pain facilitation. The previous studies explored that blockade of endogenous fractalkine, using anti-CX3CR1 neutralizing antibody, dose-dependently attenuated neuropathic pain. present study examined role fractalkine inflammatory Intra-articular injection complete Freund's adjuvant (CFA)-induced rat...
Purpose Long-standing diabetes is a risk factor for pancreatic cancer, and recent-onset in the several years before diagnosis consequence of subclinical malignancy. However, impact on survival largely unknown. Patients Methods We analyzed by status among 1,006 patients diagnosed from 1986 to 2010 two prospective cohort studies: Nurses' Health Study (NHS) Professionals Follow-Up (HPFS). validated our results 386 2004 2013 clinic-based case series at Dana-Farber Cancer Institute (DFCI)....
Objective To quantitate the 2016 global and national burden of chronic kidney disease (CKD) attributable to ambient fine particulate matter air pollution ≤ 2.5 μm in aerodynamic diameter (PM ). Design We used Global Burden Disease (GBD) study data methodologies estimate CKD PM 194 countries territories. Population-weighted levels incident rates for each country were curated from GBD publicly available sources. Setting on CKD. Participants Main outcome measures estimated (ABD), years living...
Background and objectives Experimental evidence suggests a role for monocytes in the biology of kidney disease progression; however, whether monocyte count is associated with risk incident CKD, CKD progression, ESRD has not been examined large epidemiologic studies. Design, settings, participants, & measurements We built longitudinal observational cohort 1,594,700 United States veterans at least one eGFR during fiscal year 2004 (date last this period designated time zero) no prior...
Abstract Injuries to skeletal muscle are among the most common injuries in civilian and military populations, accounting for nearly 60% of extremity injuries. The standard care severe injury has been focused upon limb salvage procedures utilization tissue grafts or orthotics conjunction with rehabilitation avoid amputation. Nonetheless, many patients have persistent strength functional deficits that permanently impact their quality life. Preclinical clinical studies shown partial restoration...
Abstract Introduction Alzheimer's disease (AD) is associated with altered metabolites. This study aimed to determine the validity of using circulating metabolites differentiate AD from other dementias. Methods Blood were measured in three data sets. Data set 1 (controls, 27; AD, 28) was used for analyzing differential 2 93; 92) establish a diagnostic model use metabolite panel. The applied 3 76; dementias, 205) verify its capacity differentiating Results revealed 7 upregulated and 77...