A5030655599- Functional Brain Connectivity Studies
- Obsessive-Compulsive Spectrum Disorders
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Ophthalmology and Visual Impairment Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Mental Health Research Topics
- Neural dynamics and brain function
- Sarcoma Diagnosis and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Eating Disorders and Behaviors
- Visual perception and processing mechanisms
- Treatment of Major Depression
- Intraocular Surgery and Lenses
- Attention Deficit Hyperactivity Disorder
- Optical Imaging and Spectroscopy Techniques
- Neural and Behavioral Psychology Studies
- Bone Tumor Diagnosis and Treatments
- Medical Imaging and Analysis
- Autism Spectrum Disorder Research
- Traumatic Ocular and Foreign Body Injuries
- Lanthanide and Transition Metal Complexes
First Affiliated Hospital of Zhengzhou University
2016-2025
High Magnetic Field Laboratory
2024
Brain (Germany)
2023
Imagerie et Cerveau
2023
Zhengzhou University
2017-2023
Zero to Three
2018
In order to examine the difference in brain structure between obese and normal weight individuals, explore relationship neuroanatomical changes impulsivity traits, this study used a voxel-based morphometry method gray matter (GM) volume alterations related impulsive personality traits individuals relative weight. Eighty adults that completed UPPS-P Impulsive Behavior Scale were analyzed. Possible GM first analyzed at whole level, then regional differences scores examined selected regions of...
Abstract The high inter-individual heterogeneity in individuals with depression limits neuroimaging studies case-control approaches to identify promising biomarkers for individualized clinical decision-making. We put forward a framework integrating the normative model and non-negative matrix factorization (NMF) quantitatively assess altered gray matter morphology from dimensional perspective. proposed parses into overlapping latent disease factors, assigns patients distinct factor...
To investigate the alterations in spontaneous brain activity and similarities differences between monocular deprivation amblyopia binocular amblyopia. Twenty children with amblyopia, 26 20 healthy controls underwent resting-state functional magnetic resonance imaging. The evaluation of altered was conducted using fractional amplitude low-frequency fluctuations (fALFF). One-way analysis variance employed to analyze fALFF values among three groups. Additionally, relationship best corrected...
Obsessive-compulsive disorder (OCD) is a highly heterogeneous disorder, with notable variations among cases in structural brain abnormalities. To address this heterogeneity, our study aimed to delineate OCD subtypes based on individualized gray matter morphological differences. We recruited 100 untreated, first-episode patients and 106 healthy controls for imaging scans. Utilizing normative models of volume, we identified individual Sensitivity analyses were conducted validate the...
Modern neuroimaging research has recognized that major depressive disorder (MDD) is a connectome disorder, characterized by altered functional connectivity across large-scale brain networks. However, the clinical heterogeneity, likely stemming from diverse neurobiological disturbances, complicates findings standard group comparison methods. This variability driven search for MDD subtypes using objective markers. In this study, we sought to identify potential subject-level abnormalities in...
Multifaceted evidence has shown that psychiatric disorders share common neurobiological mechanisms. However, the tremendous inter-individual heterogeneity among patients with limits trans-diagnostic studies case-control designs, aimed at identifying clinically promising neuroimaging biomarkers. This study aims to identify neuroanatomical differential factors (ND factors) underlying gray matter volume variations in five disorders. We leverage 4 independent datasets of 878 diagnosed and 585...
Abstract Background Major depressive disorder (MDD) is a heterogeneous condition characterized by significant intersubject variability in clinical presentations. Recent neuroimaging studies have indicated that MDD involves altered brain connectivity across widespread regions. However, the abnormal among patients remains understudied. Methods Utilizing large, multi-site dataset comprising 1,276 with and 1,104 matched healthy controls, this study aimed to investigate of structural covariance...
Background As a crucial node of the cortico-striato-thalamo-cortical (CSTC) loop, striatum has long been considered to be involved in pathophysiology obsessive-compulsive disorder (OCD). Numerous neuroimaging studies have reported functional abnormalities OCD. However, altered dynamic connectivity (DFC) patterns striatal subregions were rarely patients with Methods We collected resting-state MRI data from 97 first episode and drug-naïve OCD 106 HCs matched for gender age. Seed-based...
To investigate the alterations in dynamic neural activity visual cortex children with monocular amblyopia and its correlation neurotransmitter profiles. A total of 61 participants (thirty right eye amblyopia, thirty-one left amblyopia) 30 individuals normal vision were recruited. The functional changes brain areas, amplitude low‑frequency fluctuations (dALFF) serves as primary index. Spatial between dALFF imaging was also examined. Abnormal lingual gyrus, middle occipital calcarine fissure...
To explore the utility of whole-lesion apparent diffusion coefficient (ADC) histogram analysis for differentiating parotid gland tumors following readout-segmented diffusion-weighted imaging (RESOLVE).80 patients (40 with pleomorphic adenomas, 14 Warthin tumors, and 26 malignant tumors) who underwent routine head-and-neck MRI RESOLVE examinations, were retrospectively evaluated. data acquired from a MAGNETOM Skyra 3T MR system. Eleven parameters derived (ADC_mean, ADC_minimum, ADC_maximum,...
Background 4D flow MRI shows great potential in neurovascular disorders such as stenosis, atherosclerotic disease, aneurysms, and vascular malformations. Its widespread application the system requires evidence of good test–retest multicenter reproducibility. Purpose To assess reproducibility, reliability interobserver dependence measurements cerebral blood flow/velocity main intracranial vessels. Study Type Prospective study. Subjects Ten healthy subjects underwent scans at three different...
We aimed to develop and validate radiomic nomograms allow preoperative differentiation between benign- malignant parotid gland tumors (BPGT MPGT, respectively), as well pleomorphic adenomas (PAs) Warthin (WTs).This retrospective study enrolled 183 (68 PAs, 62 WTs, 53 MPGTs) divided them into training (n = 128) testing 55) cohorts. In total, 2553 radiomics features were extracted from fat-saturated T2-weighted images, apparent diffusion coefficient maps, contrast-enhanced T1-weighted images...
Major depressive disorder (MDD) is associated with dysfunction of the reward system. As an important node in system, resting-state functional connectivity nucleus accumbens (NAc) related to etiology MDD. However, increasing number recent studies propose that brain activity dynamic over time, no study date has examined whether NAc (DFC) changed patients Moreover, few have impact clinical characteristics A total 220 MDD and 159 healthy controls (HCs), group-matched for age, sex, education...
As a highly heterogeneous disorder, schizophrenia shows notable interindividual variation in clinical manifestations. On that account, an increasing number of studies begin to examine the variability neuroimaging characterization schizophrenia. However, whether demonstrates higher morphological than health controls (HCs) remains unknown. T1-weighted anatomical images were obtained from patients with ( n = 61) and matched HCs 73). For each subject, voxel-wise gray matter volume was using...
Epidemiological and clinical age differences in obsessive-compulsive disorder (OCD) have been reported symptoms morphometry changes; however, amplitude of low-frequency fluctuation the relationship between ALFF imaging has not thoroughly studied OCD. Age may be an important feature associated with distinct subtypes To examine effect on OCD, current study enrolled 92 OCD patients (32 pediatrics 60 adults) matched HCs (33 84 adults), undergoing resting-state functional magnetic resonance...
Abstract Background There is growing evidence that gray matter atrophy constrained by normal brain network (or connectome) architecture in neuropsychiatric disorders. However, whether this finding holds true individuals with depression remains unknown. In study, we aimed to investigate the association between and connectome at individual level depression. Methods 297 patients 256 healthy controls (HCs) from two independent Chinese dataset were included: a discovery (105 never-treated...