A5087354951- Functional Brain Connectivity Studies
- Gut microbiota and health
- Mental Health Research Topics
- Climate variability and models
- Meteorological Phenomena and Simulations
- Gastrointestinal motility and disorders
- Advanced Neuroimaging Techniques and Applications
- Advanced Sensor and Energy Harvesting Materials
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Plant biochemistry and biosynthesis
- Traditional Chinese Medicine Analysis
- Advanced Fiber Optic Sensors
- Tropical and Extratropical Cyclones Research
- Cancer-related gene regulation
- Treatment of Major Depression
- Plant responses to water stress
- Immune Cell Function and Interaction
- Advanced MRI Techniques and Applications
- Probiotics and Fermented Foods
- Neural dynamics and brain function
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Non-Invasive Vital Sign Monitoring
First Affiliated Hospital of Zhengzhou University
2021-2025
Shanghai Jiao Tong University
2019-2025
XinHua Hospital
2019-2025
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2025
Third Xiangya Hospital
2023-2025
Hunan Agricultural University
2021-2025
Central South University
2023-2025
Southwest University
2020-2025
Gansu University of Traditional Chinese Medicine
2025
Chinese People's Liberation Army
2025
Cancer immunotherapy has revolutionized cancer treatment, and it relies heavily on the comprehensive understanding of immune landscape tumor microenvironment (TME). Here, we obtain a detailed cell atlas esophageal squamous carcinoma (ESCC) at single-cell resolution. Exhausted T NK cells, regulatory cells (Tregs), alternatively activated macrophages tolerogenic dendritic are dominant in TME. Transcriptional profiling coupled with receptor (TCR) sequencing reveal lineage connections...
Abstract Stretchable physical sensors that can detect and quantify human physiological signals such as temperature, are essential to the realization of healthcare devices for biomedical monitoring human–machine interfaces. Despite recent achievements in stretchable electronic using various conductive materials structures, design optics remains a considerable challenge. Here, an optical strategy temperature sensors, which maintain stable performance even under strain deformation up 80%, is...
Decarbonization of the electric power sector is essential for sustainable development. Low-carbon generation technologies, such as solar and wind energy, can replace CO2-emitting energy sources (coal natural gas plants). As a engineering practice, long-duration storage technologies must be employed to manage imbalances in variable renewable supply electricity demand. Compressed air (CAES) an effective solution balancing this mismatch therefore suitable use future electrical systems achieve...
The overgrowth of Desulfovibrio, an inflammation promoting flagellated bacteria, has been found in ulcerative colitis (UC) patients. However, the molecular mechanism remains unestablished. relative abundance Desulfovibrio vulgaris (D. vulgaris) stool samples UC patients was detected. Mice were treated with dextran sulfate sodium to induce or without administration D. flagellin (DVF), and severity leucine-rich repeat containing 19 (LRRC19) signaling assessed. interaction between DVF LRRC19...
Flexible and stretchable strain sensors are essential to developing smart wearable devices for monitoring human activities. Such have been extensively exploited with various conductive materials structures, which, however, normally in need of complex manufacturing processes confronted the challenge achieve both large stretchability high sensitivity. Here, we report a simple low-cost optical strategy design which capable measuring strains 100% low detection limit (±0.09%), fast responsivity...
Abstract Wearable and skin‐mountable strain sensors are highly demanding for monitoring skin deformations induced by human activities. Realization of such sensor devices based on fiber‐optic approaches offers attractive advantages as electromagnetic immunity inherent electric safety in comparison to their electronic counterparts. However, sensors, conventionally made stiff silica fibers, not mechanically compliant with the soft skins have limited range (<1%) measuring large deformations....
Abstract Background As a neuroprogressive illness, depression is accompanied by brain structural abnormality that extends to many regions. However, the progressive alteration pattern remains unknown. Methods To elaborate of according illness duration, we recruited 195 never-treated first-episode patients with and 130 healthy controls (HCs) undergoing T1-weighted MRI scans. Voxel-based morphometry method was adopted measure gray matter volume (GMV) for each participant. Patients were first...
Early life events can lead to multiple diseases in adulthood. Previous studies suggested that polysorbate 80 (P80) as a widely used emulsifier pharmaceutical formulations and food industries could impair the intestinal barrier. However, whether maternal P80 (MP80) exposure affect long-term health of offspring remains unknown. In this study, we found intake retard development, disrupt barrier, cause low-grade inflammation 3-week-old offspring. 16S rRNA sequencing correlation analysis revealed
Immunotherapy targeting checkpoint blockade to rescue T cells from exhaustion has become an essential therapeutic strategy in treating cancers. Till now, little is known about the PD-L1 graphic pattern and characteristics CD8+ cells. We combined cytometry by time-of-flight (CyTOF) imaging mass (IMC) approaches analyze primary lung cancers discovered that PD-L1+CD8+ were enriched tumor lesions, spatially localized with PD-1+CD8+ Furthermore, exerted regulatory functions inhibited...
Protein arginine transferase 5 (PRMT5) has been implicated as an important modulator of tumorigenesis it promotes tumor cell proliferation, invasion, and metastasis. Studies have largely focused on PRMT5 regulating intrinsic changes in tumors; however, the effects microenvironment particularly immune cells are unknown. Here we found that targeting by genetic or pharmacological inhibition reduced lung progression immunocompromised mice; were weakened immunocompetent mice. not only decreased...
During the growth period of rapeseed, if there is continuous rainfall, it will easily lead to waterlogging stress, which seriously affect rapeseed. Currently, mechanisms rapeseed resistance stress are largely unknown. In this study, (Brassica napus) inbred lines G230 and G218 were identified as waterlogging-tolerant waterlogging-sensitive respectively, through a potted simulation field experiments. After six days at seedling stage, degree leaf aging root damage lower than those G218. A...
The epidemic of coronavirus disease-19 (COVID-19) has grown to be a global health threat. Gastrointestinal symptoms are thought common clinical manifestations apart from series originally found respiratory symptoms. human gut harbors trillions microorganisms that indispensable for complex physiological processes and homeostasis. Growing evidence demonstrate microbiota alteration is associated with COVID-19 progress severity, post-COVID-19 syndrome, characterized by decrease anti-inflammatory...
Camellia oil obtained from oleifera seeds is rich in unsaturated fatty acids and unique flavors, has become a rising high-quality edible vegetable the world. However, honored as "Oriental olive oil", was widely adulterated for situation of high price short supply. At present, identification plant mainly based on composition content acids. Here, acid main oils were determined. It found that are susceptible to change origin, variety climate raw materials, could even be made extremely similar...
Abstract Depression associated with structural brain abnormalities is hypothesized to be related accelerated aging. However, there far from a unified conclusion because of clinical variations such as medication status, cumulative illness burden. To explore whether age in never‐treated first‐episode patients depression and its association characteristics, we constructed prediction model where gray matter volumes measured by voxel‐based morphometry derived T1‐weighted MRI scans were treated...
Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease. Modulation of gut microbiota with dietary and nutritional targets a feasible strategy for the prevention treatment IBD. In this study, we focused on Clostridium butyricum Prazmowski (CB), butyrate-producing potential probiotic. We found that CB feeding decreased activity index, colon inflammation/injury score cell apoptosis in experimental colitis mouse model, as well elevated level SCFAs cecal feces. could also balance...
In vivo detection of neurochemicals, including neurotransmitters and neuromodulators, is critical for both understanding brain mechanisms diagnosing diseases. However, few sensors are competent in monitoring neurochemical dynamics at high specificity. Here, we propose the fiber-optic probes based on engineered cells (FOPECs) plug-and-play, real-time neurochemicals freely moving animals. Taking advantages life-evolved receptors as key components, chemical specificity FOPECs unprecedented. We...
Abstract Background Mental disorders, including depression, obsessive compulsive disorder (OCD), and schizophrenia, share a common neuropathy of disturbed large-scale coordinated brain maturation. However, high-interindividual heterogeneity hinders the identification shared distinct patterns network abnormalities across mental disorders. This study aimed to identify altered structural covariance Methods Subject-level aberrance in patients with disorders was investigated using individualized...
Abstract The high inter-individual heterogeneity in individuals with depression limits neuroimaging studies case-control approaches to identify promising biomarkers for individualized clinical decision-making. We put forward a framework integrating the normative model and non-negative matrix factorization (NMF) quantitatively assess altered gray matter morphology from dimensional perspective. proposed parses into overlapping latent disease factors, assigns patients distinct factor...
Microsporidians are opportunistic pathogens with a wide range of hosts, including invertebrates, vertebrates and even humans. possess highly specialized invasion structure, the polar tube. When spores encounter an appropriate environmental stimulation, tube rapidly everts out spore, forming 50-500 µm hollow that serves as conduit for sporoplasm passage into host cells. The is mainly composed proteins (PTPs). So far, five major have been isolated from microsporidians. Nosema bombycis, first...