A5030801680- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Liver Diseases and Immunity
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Gastrointestinal motility and disorders
- Cancer Research and Treatments
- Liver Disease and Transplantation
- Genetic factors in colorectal cancer
- Antimicrobial Resistance in Staphylococcus
- Diet and metabolism studies
- IL-33, ST2, and ILC Pathways
- CO2 Reduction Techniques and Catalysts
Tianjin Medical University General Hospital
2016-2025
Tianjin Medical University
2014-2024
Beijing Institute of Technology
2023-2024
Tianjin Infectious Diseases Hospital
2021-2023
Zhengzhou University
2020-2022
Hanzhong Central Hospital
2021
Guilin University of Technology
2020
Creative Research Enterprises (United States)
2016
Tianjin University
2013
Institute of Electrical Engineering
2012
The overgrowth of Desulfovibrio, an inflammation promoting flagellated bacteria, has been found in ulcerative colitis (UC) patients. However, the molecular mechanism remains unestablished. relative abundance Desulfovibrio vulgaris (D. vulgaris) stool samples UC patients was detected. Mice were treated with dextran sulfate sodium to induce or without administration D. flagellin (DVF), and severity leucine-rich repeat containing 19 (LRRC19) signaling assessed. interaction between DVF LRRC19...
BackgroundAccumulating evidence points to a close relationship between gut dysbiosis and colorectal cancer (CRC). As >90% of CRC develop from adenoma, we aimed investigate the crucial role imbalanced microbiota on progression intestinal adenoma.MethodsThe Apcmin/+ mice gavage with phosphate-buffered saline (PBS), feces healthy controls or patients after antibiotic cocktails. The tissues were isolated for histopathology, western blotting, RNA-seq. short-chain fatty acids (SCFAs) analysed by...
Incidences of nosocomial infections mediated by New Delhi metallo-β-lactamase (NDM) enzyme-producing Enterobacterales are increasing globally, resulting in a great burden to public health. The carbapenem-resistant (CRE) were collected from Henan, China during 2013-2016. blaNDM-positive strains characterized using PCR, antimicrobial susceptibility testing, conjugation assay, S1 nuclease pulsed-field gel electrophoresis (S1-PFGE), Southern blot, whole-genome sequencing (WGS), and...
Abstract The morbidity of colorectal cancer (CRC) has risen to third place among malignant tumors worldwide. In addition, CRC is a common in China whose incidence increases annually. Angiogenesis plays an important role the development because it can bring nutrients that cells need and take away metabolic waste. Various mechanisms are involved formation neovascularization, vascular endothelial growth factor key mediator. Meanwhile, angiogenesis inhibitors drug resistance (DR) challenges...
High-fat diet (HFD) has long been recognized as risk factors for the development and progression of ulcerative colitis (UC), but exact mechanism remained elusive. Here, HFD increased intestinal deoxycholic acid (DCA) levels, DCA further exacerbated colonic inflammation. Transcriptome analysis revealed that triggered ferroptosis pathway in mice. Mechanistically, upregulated hypoxia-inducible factor-2α (HIF-2α) divalent metal transporter-1 (DMT1) expression, causing ferrous ions accumulation...
Objective. Subepithelial tumors (SETs) in the stomach are usually considered benign. However, some do have potential for malignant transformation, especially when originating muscularis propria (MP). Our study aimed to evaluate clinical efficacy and safety of endoscopic submucosal dissection (ESD) gastric SETs MP. Material methods. A total 145 MP 144 patients were treated by ESD between September 2008 December 2012. Characteristics SETs, therapeutic outcomes, pathologic characteristics,...
Gastrointestinal stromal tumors (GISTs), the most common mesenchymal of digestive tract with potential for malignant transformation, are mainly treated by open surgery or laparoscopic resection. The aim this retrospective study was to evaluate clinical efficacy, safety, and feasibility endoscopic submucosal dissection (ESD) large-size (2-5 cm) GISTs in esophagus stomach.A total 31 patients (6 patients) stomach (25 underwent ESD between September 2008 December 2011. Demographics, data,...
To investigate whether the transfer of IL-37b gene, a newly identified inhibitor both innate and adaptive immunity, could improve therapeutic efficacy mesenchumal stromal cells (MSCs) in inflammatory bowel disease (IBD). The expression IL-37 biopsied specimens patients with active ulcerative colitis (UC) was detected using RT-PCR immunohistochemistry. Mice were treated 3% dextran sulfate sodium (DSS) for 8 days to induce colitis. Before DSS treatment, mice injected MSCs, MSC-eGFP or...
Pancreatic segmental portal hypertension (PSPH) is a clinical syndrome in which splenic vein caused by obstruction, stenosis, or thrombosis of the veins primary pancreatic disease. Gastrointestinal hemorrhage gastric varices (GVs) one life-threatening complications patients with left hypertension. The aim was to report our experience and discuss manifestations, management, prognosis PSPH upper gastrointestinal bleeding (UGIB). We retrospectively analyzed six UGIB department. data were...
Based on endoscopic ultrasonography (EUS) radiomics and clinical data, we constructed a model nomogram for identifying benign malignant pancreatic lesions, explored the diagnostic performance of these two prediction models. Images data 151 patients with lesions detected by EUS from January 2018 to September 2023 were retrospectively collected. The randomly divided into training set validation at ratio 7:3. Through feature extraction screening images, calculated score (rad-score) realize...
Maternal high fat diet (MHFD) increased colitis susceptibility in adulthood. However, the mechanism remains unclear. We sought to explore whether novel gut immune receptor leucine-rich repeat C19 (LRRC19) contributed impaired mucus barrier of offspring exposed MHFD via response and microbiota. The results showed that significantly intestinal offspring, up-regulated expression LRRC19. Lrrc19 deletion alleviated disruption. Mechanistically, metagenome sequencing revealed MHFD-induced...
<title>Abstract</title> Severe aplastic anemia is a life-threatening ineffective hematopoiesis, arising from inherited or acquired traits. Wilson disease rare congenital metabolic disorder with copper accumulation. Here we report case of 15 year-old boy, who presented bone marrow failure. Whole exome sequencing revealed several gene mutations in ATP7B and TERT. Based on the phenotypes, telomere lengths pedigree his family, patient was diagnosed accompanied by disease. Allogeneic...
Objective:The prognosis for gastric cancer (GC), a prevalent tumor of the digestive system, is unfavorable.The involvement glutathione peroxidase 3 (GPX3) in tumorigenesis significant, yet its specific role GC remains insufficiently investigated.Thus, aim this study was to determine potential impact GPX3 on and elucidate underlying mechanism.Methods: The expression survival were analyzed using TCGA data.Additionally, mRNA protein levels also assessed datasets from GTEx, GEPIA, HPA.A total 38...
A mononuclear iron-sulfur center, capable of reversible electron transfer, has been introduced into thioredoxin, a protein devoid such sites, using an automated, structure-based design algorithm. One the sites predicted by Dezymer computer program to introduce tetrahedral tetrathiolate iron center included intrinsic Cys32−Cys35 disulfide wild-type thioredoxin and two additional mutants, Trp28Cys Ile75Cys, thereby converting metal-based redox center. This designed forms 1:1 monomeric complex...
Background/Aims: Neutrophils obtain immunosuppressive function during tumor development, yet the mechanisms are largely unknown. This study explored whether and how mesenchymal stromal cells (MSCs), key component of microenvironment, regulate suppressive neutrophils. Methods: Immunosuppressive neutrophils was evaluated by T cell proliferation assay 4T1 breast model; molecular were transcriptional profiling, Real-time RT-PCR, arginase activity assay, iNOS inhibition experiments. Results:...
Patients with prolonged inflammatory bowel disease (IBD) can develop into colorectal cancer (CRC), also called colitis-associated (CAC). Studies have shown the association between gut dysbiosis, abnormal bile acid metabolism, and inflammation process. Here, we aimed to investigate these two factors in CAC model. C57BL/6 mice were randomly allocated groups: azoxymethane/dextran sodium sulfate (AOM/DSS) control. The AOM/DSS group received AOM injection followed by DSS drinking water....
The prevalence of inflammatory bowel disease (IBD) is increasing worldwide and correlates with dysregulated immune response because gut microbiota dysbiosis. Some adverse early life events influence the establishment act as risk factors for IBD. Prenatal maternal stress (PNMS) induces dysbiosis perturbs neuroimmune network offspring. In this study, we aimed to investigate whether PNMS increases susceptibility offspring colitis in adulthood. related index was assessed during weaning period We...