A5031361993- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Autophagy in Disease and Therapy
- Growth Hormone and Insulin-like Growth Factors
- Tryptophan and brain disorders
- Antioxidants, Aging, Portulaca oleracea
- Autoimmune Bullous Skin Diseases
- Metastasis and carcinoma case studies
- Coenzyme Q10 studies and effects
- Gastrointestinal disorders and treatments
- Endoplasmic Reticulum Stress and Disease
- Hypertrophic osteoarthropathy and related conditions
- Agriculture Sustainability and Environmental Impact
- Colorectal Cancer Screening and Detection
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- Helicobacter pylori-related gastroenterology studies
- High Altitude and Hypoxia
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Dermatological and Skeletal Disorders
- Food composition and properties
- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
Tianjin Medical University General Hospital
2019-2023
Tianjin Medical University
2017-2019
Lactic acid, a metabolic by-product of host and intestinal microbiota, has been recovered as an active signal molecule in the immune system. In this study, lactic acid biosynthesis pathway that directly produces from glucose rather than ethanol with high production was reconstructed Saccharomyces cerevisiae . The engineered S. showed anti-inflammatory activity dextran sulfate sodium (DSS)-induced mice improved histological damage, increased mucosal barrier, decreased response. regulated...
Apoptosis of gastric mucosa epithelial cells caused by the abuse alcohol produces injury to and acute or chronic gastritis. In recent years, it has been demonstrated that endoplasmic reticulum stress (ERS) is involved in mediating apoptosis, autophagy a protective effect on survival cells. Rebamipide mucosal protectant used treat gastritis stomach ulcers. this study, ethanol was overstimulate gavage mice. It found 400 mmol/L overstimulation could activate ERS induce apoptosis (control vs...
Objective:The prognosis for gastric cancer (GC), a prevalent tumor of the digestive system, is unfavorable.The involvement glutathione peroxidase 3 (GPX3) in tumorigenesis significant, yet its specific role GC remains insufficiently investigated.Thus, aim this study was to determine potential impact GPX3 on and elucidate underlying mechanism.Methods: The expression survival were analyzed using TCGA data.Additionally, mRNA protein levels also assessed datasets from GTEx, GEPIA, HPA.A total 38...
Scope: Gut microbiome-derived metabolites are the major mediators of diet-induced host-microbial interactions. Aryl hydrocarbon receptor (AHR) plays a crucial role in glucose, lipid, and cholesterol metabolism liver. In this study, we aimed to investigate indole-3-acetic acid (IAA) AHR sulforaphane (SFN) alleviates hepatic steatosis mice fed on high-fat diet (HFD). Methods Results: The HFD-fed male C57BL/6 were intervened with SFN for 6 weeks. HFD-mice showed classical pathophysiological...
Accurate assessment of lymph node status in gastric cancer (GC) patients can help to select appropriate treatment strategies for GC, but the diagnostic accuracy conventional methods needs be improved. The aim this study was investigate predictive value preoperative hemoglobin and albumin levels lymphocyte platelet counts (HALP) on GC construct a risk prediction model.This retrospectively analyzed clinicopathological characteristics 349 with who underwent radical gastrectomy, among which 250...
There are many risk factors for the recurrence of colorectal adenoma (CRA). The purpose this study was to explore predictive performance fibrinogen-to-lymphocyte ratio (FLR) and neutrophil-to-lymphocyte (NLR) on CRA construct a model.This analyzed clinicopathological features 421 patients who underwent colonoscopy adenectomy, evaluated polyps under colonoscopy. Among them, 301 were training cohort 120 validation cohort. Multivariate logistic regression used identify independent associated...
Objective: Endoscopy is the main method to treat gastrointestinal neuroendocrine tumors (GI-NETs), but specific indications are still controversial. We aim investigate clinical outcomes of GI-NETs patients who experienced endoscopic submucosal dissection (ESD). Methods: retrospectively reviewed features and prognosis 65 underwent ESD between 2008 2018. Results: A total diagnosed with pathologically, bearing 75 lesions, were found by endoscopy incidentally for other symptoms. The locations...