A5071430124- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Esophageal Cancer Research and Treatment
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Medical Imaging and Pathology Studies
- MRI in cancer diagnosis
- Radiation Dose and Imaging
- Endometrial and Cervical Cancer Treatments
- Radiopharmaceutical Chemistry and Applications
- Cancer-related molecular mechanisms research
- Effects of Radiation Exposure
- Advanced Radiotherapy Techniques
- Helicobacter pylori-related gastroenterology studies
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- BRCA gene mutations in cancer
- Head and Neck Cancer Studies
- Management of metastatic bone disease
- DNA Repair Mechanisms
- Glioma Diagnosis and Treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
National Clinical Research
2022-2025
National Cancer Center
2016-2025
Cancer Foundation of China
2025
Wenzhou Medical University
2010-2023
Tianjin Medical University General Hospital
2022-2023
Donghua University
2023
Baylor College of Medicine
2022
Fujian University of Traditional Chinese Medicine
2020-2022
Shaanxi University of Chinese Medicine
2022
Because reduced DNA repair capacity (phenotype) has been suggested as a risk factor for squamous cell carcinoma of the head and neck (SCCHN), newly-identified gene polymorphisms (genotype) may also be implicated in risk. To test this hypothesis, we conducted case-control study 203 SCCHN patients 424 control subjects (matched age, sex ethnicity) to investigate role two XRCC1 ( 26304 T 28152 A, respectively) SCCHN. Multivariate logistic regression analysis was performed calculate adjusted odds...
Chimeric antigen receptor (CAR)-mediated targeting of T lineage antigens for the therapy blood malignancies is frequently complicated by self-targeting CAR cells or their excessive differentiation driven constant signaling. Expression CARs CD7, a pan-T cell highly expressed in and some myeloid leukemias, produces robust fratricide often requires additional mitigation strategies, such as CD7 gene editing. In this study, we show can be fully prevented using ibrutinib dasatinib, pharmacologic...
Objective:The prognosis for gastric cancer (GC), a prevalent tumor of the digestive system, is unfavorable.The involvement glutathione peroxidase 3 (GPX3) in tumorigenesis significant, yet its specific role GC remains insufficiently investigated.Thus, aim this study was to determine potential impact GPX3 on and elucidate underlying mechanism.Methods: The expression survival were analyzed using TCGA data.Additionally, mRNA protein levels also assessed datasets from GTEx, GEPIA, HPA.A total 38...
Abstract We present a case of 37-year-old man with multiple masses in the abdominal and pelvic cavity who underwent 18 F-AlF-NOTA-octreotide PET/CT. The demonstrated heterogeneously increased uptake on PET/CT were suggestive neuroendocrine tumor. However, histopathological examinations confirmed to be peritoneal mesothelioma. This indicated that mesothelioma should kept mind as one differential diagnoses for F-AlF-NOTA-octreotide-avid tumors.
Background: Accurate diagnosis and staging are crucial for the management of patients with hepatobiliary malignancies. Here, we investigated efficacy Al 18 F-NOTA-FAPI-74 PET/CT in detecting malignancies compared results F-FDG PET/CT. Patients Methods: Participants were prospectively enrolled underwent paired from April 2023 to March 2024. Histopathology and/or follow-up imaging served as reference standard. The SUVmax primary metastatic lesions between using Wilcoxon signed-rank test....
Radiation is the only clear etiologic agent for differentiated thyroid cancer (DTC). Understanding factors affecting sensitivity to gamma radiation and susceptibility DTC will be critical early detection prevention of DTC.Germline variants double-strand break repair genes are markers risk.Determine frequency common single nucleotide polymorphisms pathway in patients with cancer-free controls.Case-control study.This study included 134 DTC, 79 benign lesions, 166 control subjects. To avoid...
ObjectivesTo investigate the prognostic capacity of baseline 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) metabolic parameters in extranodal natural killer/T-cell lymphoma (ENKTCL), and influence relative thresholds (RT) absolute (AT) selection on capacity.Materials methodsMetabolic tumor volume (MTV)-based were defined using RTs (41 % or 25 maximum standardized uptake value [SUVmax]), ATs (SUV 2.5, 3.0, 4.0, mean liver uptake) 133 patients....
Abstract In this study, the self-extracted constipation treatment of traditional Chinese medicine extracts was applied to constipated rats. To explore mechanism and role for constipation, 16S rRNA sequencing qRT-PCR technology were used analyze intestinal flora. We found that relative abundance Firmicutes with significantly higher accounted 86.7%, while gut microbiota changed after taking a certain dose medicine, greatly increased Lactobacillus 23.1%, enhanced symbiotic relationships other...
Chimeric antigen receptor (CAR)-T cell therapy has been shown to have considerable therapeutic effects in hematological malignancies, and NKG2D(z) CAR-T verified be safe based on clinical trials. However, due the poor persistence of cells, their effect is not obvious. Here, we constructed NKG2D(bbz) cells that can simultaneously activate 4-1BB DAP10 costimulatory signaling. They were found cytotoxic target vitro vivo . exhibited low differentiation, exhaustion, good proliferation....
Abstract Chronic atrophic gastritis (CAG) is well-known related with multiple pathogenic factors and normally therapies comprised by western or Chinese medicines. The present study was designed to identify the bacterial community characterized 16S rRNA amplicon sequencing determine modulate affection of composition response medicine Qinghuayin (QHY) as well antibiotic on model rats. result shown overall structure alteration appeared under intervened, caused a marked depletion in diversity...
To assess the utility of skeletal standardized uptake values (SUVs) obtained using quantitative single-photon emission computed tomography/computed tomography (SPECT/CT) in differentiating bone metastases from benign lesions, particularly patients with lung adenocarcinoma.Patients adenocarcinoma who had undergone whole-body Tc-99m methyl-diphosphonate (99mTc-MDP) scans and received late phase SPECT/CT were retrospectively analyzed this study. The maximum SUV (SUVmax); Hounsfield units (HUs);...
The aim of the study was to assess prognostic impact volume-based metabolic F-fluorodeoxyglucose-positron emission tomography/ computed tomography (F-FDG-PET/CT) parameters in patients with stage IB-IVA squamous cell cervical carcinoma (SCCC).We reviewed pretreatment F-FDG-PET/CT records 67 SCCC. maximum standardized uptake value (SUVmax) primary tumor (PSUVmax), highest SUVmax whole malignant lesions (WSUVmax), volume (MTV) (PMTV), MTV lesion (WMTV), total glycolysis (TLG) (PTLG), and TLG...
Objective: To determine the association between glutathione S-transferase (GST) polymorphisms and risk of differentiated thyroid carcinoma (DTC) benign tumors.Design: Case-control study.Setting: Tertiary care cancer
Abstract Positivity of follicular dendritic cell tumor in somatostatin receptor imaging is rare. A 68-year-old woman underwent ultrasound health examination. The results showed abnormal echoes the pancreatic head region, suggestive a neuroendocrine head. 18 F-AlF-NOTA-octreotide PET/CT was performed for staging. revealed an irregular mass between caudate lobe liver and with heterogeneously increased uptake, which later confirmed as by pathological
Abstract A 25-year-old woman experiencing dysphagia for 2 years underwent 18 F-FDG and Al F-FAPI-74 PET/CT. The scans showed local thickening of the cervical upper thoracic esophageal wall with several calcifications, accompanied by increased heterogeneous FDG uptake more intense FAPI activity. Histopathological analysis following thoracoscopic esophagectomy confirmed diagnosis inflammatory pseudotumor.
Abstract Background. The purpose of this study was to examine the association between 4 Fas single nucleotide polymorphisms (SNPs) and risk differentiated thyroid carcinoma (DTC) salivary gland (SGC). Methods. We conducted a case‐control including 279 DTC cases, 165 benign disease (BTD) 154 SGC 61 (BSGD) 510 controls. Results. A744G SNP genotype distribution significantly different subjects with or BSGD controls, while that A18272G Risk elevated for 22628 heterozygous CT (odds ratio [OR] =...
Abstract Background. While radiation has been the only well‐established risk factor for salivary and thyroid cancers, exact mechanisms remain unknown. We hypothesized that individuals with altered apoptotic response to γ irradiation may be susceptible cancers. Methods. tested our hypothesis in a pilot case‐control study of 29 patients neoplasms glands cancer‐free control subjects. Patients subjects were matched on age, sex, ethnicity. In vitro radiation–induced apoptosis lymphocytes was...