A5108058543- Glioma Diagnosis and Treatment
- Aortic aneurysm repair treatments
- MicroRNA in disease regulation
- Brain Metastases and Treatment
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Circular RNAs in diseases
- Hearing, Cochlea, Tinnitus, Genetics
- Yersinia bacterium, plague, ectoparasites research
- Microtubule and mitosis dynamics
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- Gut microbiota and health
- Head and Neck Surgical Oncology
- Forensic and Genetic Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell death mechanisms and regulation
Hebei Medical University
2012-2024
Second Hospital of Hebei Medical University
2008-2024
Health Commission of Anhui Province
2024
Weatherford College
2024
University of Chinese Academy of Sciences
2023-2024
City University of Hong Kong
2023-2024
BGI Group (China)
2023-2024
Capital Medical University
2023-2024
Beijing Tian Tan Hospital
2023-2024
Shanghai Jiao Tong University
2023-2024
Polycations that absorb protons in response to the acidification of endosomes can theoretically disrupt these vesicles via "proton sponge" effect. To exploit this mechanism, we created nanoparticles with a segregated core−shell structure for efficient, noncytotoxic intracellular drug delivery. Cross-linked polymer were synthesized pH-responsive core and hydrophilic charged shell designed mediate drug/cell binding, respectively. By sequestering relatively hydrophobic component within more...
One thousand three hundred seventy-nine nasopharyngeal carcinoma (NPC) patients were treated from March 1958 to December 1978. Twenty-two percent had stage I or II and 78% Stage III IV lesions. Two twenty-Kv radiographs used before 1960; telecobalt was 1961 Factors influencing the 5-year survival rate favorably are youth of patient, being female, pathologic condition (poorly differentiated carcinoma, 45.1% versus adenocarcinoma, 13%), (Stage I, 86%, II, 59.5%; III, 45.8%; IV, 29.2%), decade...
We recently described a strategy for intracellular delivery of macromolecules, utilizing pH-responsive "core-shell" structured gel particles. These cross-linked hydrogel particles disrupt endosomes with low toxicity by virtue physical sequestration an endosome-disrupting "proton sponge" core inside nontoxic hydrophilic shell. Here we tested the efficacy this system cytosolic broad range macromolecular cargos, and demonstrate proteins, whole viral particles, or siRNA oligonucleotides into...
Glioma stem cells (GSCs) derived extracellular vesicles (EVs) can mediate the communication between GSCs and microglia. MALAT1 expression in GSCs, EVs, supernatant was detected by real-time PCR. The direct targeting miR-129-5p, miR-129-5p HMGB1 were tested with luciferase reporter analysis. secretion of interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α determined lipopolysaccharide-stimulated microglia or inhibitor transferred exposing to EVs from siMALAT1 pre-transferred GSCs....
Abstract Vascular smooth muscle cell (VSMC) phenotypic switching plays a critical role in the formation of abdominal aortic aneurysms (AAAs). FoxO3a is key suppressor VSMC homeostasis. We found that human and animal AAA tissues, was upregulated, SM22α α-smooth actin (α-SMA) proteins were downregulated synthetic markers indicating occurred these diseased tissues. In addition, cultured VSMCs, significant enhancement expression during angiotensin II (Ang II)-induced switching. vivo,...
Abstract Background The gut microbiome plays an important role in various cardiovascular diseases, such as atherosclerosis and hypertension, which are associated with abdominal aortic aneurysms (AAAs). Methods Here, we used 16S rRNA sequencing to explore microbiota C57BL ApoE −/− mice AAAs. A mouse model of was induced angiotensin II (Ang II) (1000 ng/min per kg). On day 28 after the operation, fecal samples were collected stored at − 80 °C until DNA extraction. We determined relative...
The prognostic factors for survival in patients with ependymoma (EPN) remain controversial. aim of this study was to establish a model 5- and 10-year probability nomograms EPN.Clinical data from the Surveillance, Epidemiology, End Results (SEER) database were used diagnosed between 2000 2018 randomized 7:3 into development set validation set. Factors significantly associated prognosis screened out using least absolute shrinkage selection operator (LASSO) regression. calibration chart...
Abstract Background The age of glioma plays a unique role in prognosis. We hypothesized that is not positively correlated with survival prognosis and explored its exact relationship. Methods Glioma was identified from the SEER database (between 2000 2018). A multivariate Cox proportional regression model restricted cubic spline (RCS) plot were used to assess relationship between Results total 66465 patients included. Hazard ratios (HR) for ten-year by age: 0–9 years, HR 1.06 (0.93–1.20);...
Abstract Background Microglia are important immune cells, which can be induced by lipopolysaccharide (LPS) into M1 phenotype that express pro-inflammatory cytokines. Some studies have shown microRNAs play critical roles in microglial activation. Objective This study was designed to investigate the role of miR-200c-3p regulating inflammatory responses LPS-treated BV2 cells. Methods The expression cells detected real-time PCR. Receptor-interacting protein 2 (RIP2) predicted as a target gene...
World Health Organization (WHO) Grade III meningioma is a central nervous system tumor with poor prognosis. In this retrospective cohort study, the authors constructed nomogram for predicting prognosis of WHO meningioma.The patients were based on Surveillance, Epidemiology, and End Results (SEER) database between 2000 2018. All randomly divided into development (964 patients) validation (410 in 7:3 ratio. The least absolute shrinkage selection operator (LASSO) regression was used to screen...
BackgroundA domestic surfactant preparation has been used in China for a number of years. However, as other preparations, there is debate among neonatologists regarding the optimal dose, mode administration, and best time intervention.ObjectiveTo evaluate whether prophylactic administration superior to early treatment preterm infants < 32 weeks with high risk respiratory distress syndrome (RDS).MethodsWe prospectively compared small premature (< weeks) receiving 70 mg/kg bovine within 30...
Hearing loss is genetically heterogeneous and one of the most common human defects. Here we screened underlying mutations that caused autosomal recessive non-syndromic hearing in a Chinese family. The proband with profound had received audiometric assessments. We performed target region capture next generation sequencing 127 known deafness-related genes because individual tested negative for hotspot variants GJB2, GJB3, SLC26A4, MTRNR1 genes. identified novel c.6892C > T (p.R2298*) nonsense...
Abstract Background Few studies have evaluated the clinical presentation, management, and outcomes of patients with end-stage renal disease (ESRD) presenting acute aortic dissection (AAD) in real-world practice. Thus, this study investigated characteristics, AAD ESRD. Methods A total 217 were included. We differences features, in-hospital without a history ESRD AAD. Results was present 71 patients. Patients had atypical manifestations ( p < 0.001) more likely to be managed medically...