A5002490436- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Virus-based gene therapy research
- Thyroid and Parathyroid Surgery
- Nonmelanoma Skin Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Research and Treatments
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Genetic factors in colorectal cancer
- Skin and Cellular Biology Research
- Head and Neck Anomalies
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Cutaneous Melanoma Detection and Management
- Tumors and Oncological Cases
- NF-κB Signaling Pathways
- BRCA gene mutations in cancer
- Tracheal and airway disorders
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
Tampa General Hospital
2016-2024
The University of Texas MD Anderson Cancer Center
2009-2023
University of Michigan
2011-2023
York University
2023
University of Pittsburgh Medical Center
2023
University of Colorado Health
2023
UPMC Health System
2023
Cornell University
2023
Tokyo Medical and Dental University
2023
AdventHealth Tampa
2022
<h2>Summary</h2> Papillary thyroid carcinoma (PTC) is the most common type of cancer. Here, we describe genomic landscape 496 PTCs. We observed a low frequency somatic alterations (relative to other carcinomas) and extended set known PTC driver include <i>EIF1AX</i>, <i>PPM1D</i>, <i>CHEK2</i> diverse gene fusions. These discoveries reduced fraction cases with unknown oncogenic from 25% 3.5%. Combined analyses variants, expression, methylation demonstrated that different groups lead...
Abstract Purpose: Aggressive cutaneous squamous cell carcinoma (cSCC) is often a disfiguring and lethal disease. Very little currently known about the mutations that drive aggressive cSCC. Experimental Design: Whole-exome sequencing was performed on 39 cases of cSCC to identify driver genes novel therapeutic targets. Significantly, mutated were identified with MutSig or complementary methods developed specifically candidate tumor suppressors based upon their inactivating mutation bias....
Purpose To identify nonmelanoma skin cancer patients with squamous cell carcinoma (SCC) who are at greatest risk of disease-specific mortality. Patients and Methods Prospectively enrolled a minimum one pathologically confirmed SCC lesion, definitive treatment the lesion(s) resulting in no evidence disease, least 2 months follow-up after were eligible for present longitudinal analysis. They received comprehensive clinical, pathologic evaluations patterns failure Results We 210 (187 men 23...
Intracranial complications of paranasal sinusitis constitute true surgical and medical emergencies. The charts all patients (n = 649) admitted for acute or chronic to the University Minnesota Hospital Michigan Medical Center during a 13-year period (1975 1988) were retrospectively reviewed determine incidence complications. clinical presentation, bacteriology, involved sinuses, influencing host factors, white blood cell count on length hospitalization, postinterventional are presented....
Abstract Purpose: Human cell lines are useful for studying cancer biology and preclinically modeling therapy, but can be misidentified cross-contamination is unfortunately common. The purpose of this study was to develop a panel validated head neck representing the spectrum tissue sites histologies that could used molecular, genetic, phenotypic diversity cancer. Methods: A 122 clinically phenotypically diverse from squamous carcinoma, thyroid cancer, cutaneous adenoid cystic oral...
Abstract Purpose: Thyroid cancer cell lines are valuable models but have been neglected in pancancer genomic studies. Moreover, their misidentification has a significant problem. We aim to provide validated dataset for thyroid researchers. Experimental Design: performed next-generation sequencing (NGS) and analyzed the transcriptome of 60 authenticated compared our findings with known defects human cancers. Results: Unsupervised transcriptomic analysis showed that 94% clustered distinctly...
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated cancers, yet molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions cancer, including 213 patients primary anaplastic carcinomas. also whole genome 9 using multi-region sequencing both and cancer components. Using these data, we demonstrate thatanaplastic carcinomas have a higher burden mutations than other distinct mutational signatures...
PURPOSE Standard therapies of head and neck squamous cell carcinoma (HNSCC) often cause profound morbidity have not significantly improved survival over the last 30 years. Preclinical studies showed that adenoviral vector delivery wild-type p53 gene reduced tumor growth in mouse xenograft models. Our purpose was to ascertain safety therapeutic potential (Ad)-p53 advanced HNSCC. PATIENTS AND METHODS Patients with incurable recurrent local or regionally metastatic HNSCC received multiple...
Because reduced DNA repair capacity (phenotype) has been suggested as a risk factor for squamous cell carcinoma of the head and neck (SCCHN), newly-identified gene polymorphisms (genotype) may also be implicated in risk. To test this hypothesis, we conducted case-control study 203 SCCHN patients 424 control subjects (matched age, sex ethnicity) to investigate role two XRCC1 ( 26304 T 28152 A, respectively) SCCHN. Multivariate logistic regression analysis was performed calculate adjusted odds...
Because parathyroid carcinoma is rare, clear consensus not available regarding the optimal management of patients with this condition. Treatment strategies generally derive from clinical and anecdotal experiences. We report our experience entity.We included all seen at The University Texas M. D. Anderson Cancer Center since January 1, 1980. medical records pathology specimens were reviewed verified in cases.Since 1980, 27 (16 men 11 women) registered a minimum follow-up 2 years. age initial...
Abstract Objective/Hypothesis: Cutaneous squamous cell carcinoma (CSCC) has been reported to metastasize parotid and cervical lymph nodes. Few prospective investigations of associated clinical histopathologic findings their effect on patient outcomes exist. We seek identify risk factors for nodal metastases in CSCC determine the impact lymphatic spread survival recurrence. Study Design: Subset analysis a prospective, longitudinal database patients with at comprehensive cancer center....
Desquamation of the stratum corneum is a serine protease-dependent process. Two members human tissue kallikrein (KLK) family (chymo)tryptic-like proteases, KLK5 and KLK7, are implicated in desquamation by digestion (corneo)desmosomes inhibition desquamation-related protease inhibitors (SPIs). However, epidermal localization specificity additional KLKs also supports role for these enzymes desquamation. This study aims to delineate probable contribution KLK1, KLK5, KLK6, KLK13, KLK14 examining...
Abstract BRAK/CXCL14 is a CXC chemokine constitutively expressed at the mRNA level in certain normal tissues but absent from many established tumor cell lines and human cancers. Although multiple investigators cloned BRAK, little known regarding physiologic function of BRAK or reason for decreased expression cancer. To understand possible significance associated with loss tumors, we examined pattern protein specimens patients squamous carcinoma (SCC) tongue used recombinant (rBRAK) to...
To evaluate the clinical potential of fluorescence spectroscopy (a noninvasive technique for assessing chemical and morphologic composition tissue) in vivo detection oral cavity neoplasia.A system recorded spectra from sites 8 healthy volunteers 15 patients with premalignant or malignant lesions at 337-, 365-, 410-nm excitation wavelengths emission range 350 to 700 nm. Fluorescence peak intensities spectral line shapes were compared diagnostic algorithms developed distinguish normal abnormal...
Sinonasal neuroendocrine tumors are rare malignancies that represented by a spectrum of histologies, including esthesioneuroblastoma (ENB), sinonasal undifferentiated carcinoma (SNUC), (NEC), and small cell (SmCC). The authors reviewed their institutional experience to determine whether different histologies have distinct clinical characteristics warrant individualized treatment approaches.The treated 72 adults with pathologically proven, nonmetastatic, primary from 1982 2002. There were 31...
Background: Ultrasound (US) of the central neck compartment (CNC) is considered limited sensitivity for nodal spread in papillary thyroid cancer (PTC); elective dissection commonly advocated even absence sonographic abnormalities. We hypothesized that US an accurate predictor long-term disease-free survival, regardless use patients with PTC. Methods: A retrospective chart review 331 consecutive PTC treated total thyroidectomy at M.D. Anderson Cancer Center between 1996 and 2003 was...