A5027873051- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- Thyroid Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Diabetes and associated disorders
- BRCA gene mutations in cancer
- Cancer Research and Treatments
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- Diabetes Management and Research
- PARP inhibition in cancer therapy
- Oral Health Pathology and Treatment
- Cannabis and Cannabinoid Research
- Cancer Immunotherapy and Biomarkers
- Abdominal vascular conditions and treatments
Western University
2018-2024
Cleveland Clinic
2024
Alfaisal University
2024
Stanford University
2023-2024
King Faisal Specialist Hospital & Research Centre
2023-2024
Chirayu Medical College & Hospital
2024
Mount Sinai Hospital
2023
Icahn School of Medicine at Mount Sinai
2023
Yale University
2020
London Health Sciences Centre
2019-2020
The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on patient's life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into role genetics in prognosis. We identify noncoding polymorphism FOXO3A (rs12212067: T > G) at which minor (G) allele, despite not being associated with susceptibility, milder...
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated cancers, yet molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions cancer, including 213 patients primary anaplastic carcinomas. also whole genome 9 using multi-region sequencing both and cancer components. Using these data, we demonstrate thatanaplastic carcinomas have a higher burden mutations than other distinct mutational signatures...
BackgroundThere is significant interest in treatment de-escalation for human papillomavirus-associated (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients given the generally favourable prognosis. However, 15–30% of recur after primary treatment, reflecting a need improved risk-stratification tools. We sought to develop molecular test risk stratify HPV+ OPSCC patients.MethodsWe created an immune score (UWO3) associated with survival outcomes six independent cohorts comprising 906...
The anti-tumor properties of cannabinoids have been investigated in many vitro and vivo studies. Many these effects are mediated via cannabinoid receptor types 1 2 (CB1 CB2), comprising the endocannabinoid system (ECS). In this study, we ECS based on CB gene protein expression renal cell carcinoma (RCC) lines. view their further use for potential treatments, thus roles CB1 CB2 receptors anti-proliferative action signal transduction triggered by synthetic agonists [such as JWH-133 WIN...
ABSTRACT Background Obstructive sleep apnea (OSA) is a highly prevalent, yet under‐diagnosed disorder and has strong association with type 2 diabetes diabetic retinopathy (DR). Vascular abnormalities, nocturnal glucose dysregulation, impaired blood flow, hypoxia during OSA induce oxidative stress promote the inflammatory pathways which increase VEGF factor levels, leading to progression of DR. Aims To date, continuous positive airway pressure (CPAP) most effective, gold‐standard treatment...
In recent years, genome-wide RNA expression analysis has become a routine tool that offers great opportunity to study and understand the key role of genes contribute carcinogenesis. Various microarray platforms statistical approaches can be used identify might serve as prognostic biomarkers developed antitumor therapies in future. Metastatic renal cell carcinoma (mRCC) is serious, life-threatening disease, there are few treatment options for patients. this study, we performed one-color gene...
Recent advancement in cancer research has shown that tumors are highly heterogeneous, and multiple phenotypically different cell populations found a single tumor. Cancer development tumor growth driven by specific types of cells-stem cell-like cells (SCLCCs)-which also responsible for metastatic spread drug resistance. This was designed to verify the presence SCLCCs renal lines. Subsequently, we aimed characterize phenotype biology CD105+ cells, defined previously as carcinoma...
Phosphoinositide 3-kinase (PI3K) is aberrantly activated in head and neck squamous cell carcinomas (HNSCC) plays a pivotal role tumorigenesis by driving Akt signaling, leading to survival proliferation. Phosphorylation of Thr308 PI3K-PDK1 Ser473 mammalian target rapamycin complex 2 (mTORC2) activates Akt. Targeted inhibition PI3K major area preclinical clinical investigation as it reduces phosphorylation, suppressing downstream mTORC1 activity. However, releases feedback mTORC2, resulting...
Smoking has historically been recognized as a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). This study aimed to assess the mutational differences between heavy smokers (>20 pack years) never among HNSCC patients within The Cancer Genome Atlas (TCGA). Single nucleotide variation copy number aberration were compared human papillomavirus-positive (HPV-positive) (n = 67) HPV-negative 431) TCGA cohorts with HNSCC, impact of these mutations on survival assessed. No...
Clear cell renal carcinoma (ccRCC) is the most common kidney cancer. Prognosis for ccRCC generally poor since it largely resistant to chemo- and radiotherapy. Many studies suggested that cancer stem cells/tumor initiating cells (CSCs/TICs) are responsible development of tumor, disease progression, aggressiveness, metastasis drug resistance. However, tumorigenic potential CSCs/TICs isolated from established RCC lines - basic research model has never been investigated in vivo. CD105+, CD105-,...
The role of oxidized immunoglobulin G in type 1 diabetic smokers has been investigated the present study. Human (IgG) was modified by reactive oxygen species (ROS). binding characteristics circulating autoantibodies diabetes patients against native and IgG were assessed direct ELISA. High degree specific 68.5% sera towards ROS-modified observed comparison to its analogue (p< 0.05). In addition, (n=28) examined results compared with non-smokers (n=26). Circulating antibodies showed...
Metastasis is a complex process that propagates cells from the primary or initial site of cancer occurrence to distant parts body. Cancer break and circulate through bloodstream lymph vessels, allowing them reach nearly all These circulating tumour (CTCs) contain specialized metastasis-initiating (MICs) reside in biological heterogeneous tumour. Researchers have hypothesized metastasis renal cell carcinoma initiated by circulation MICs patients' blood bone marrow. Based on stem/progenitor...