Johana Gutierrez
A5066659235- Acute Lymphoblastic Leukemia research
- Pancreatic and Hepatic Oncology Research
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Phagocytosis and Immune Regulation
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- PI3K/AKT/mTOR signaling in cancer
- Pancreatitis Pathology and Treatment
- Gut microbiota and health
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Liver physiology and pathology
- Pharmacological Effects of Natural Compounds
- Immune Response and Inflammation
- Cholangiocarcinoma and Gallbladder Cancer Studies
Cornell University
2020-2024
Weill Cornell Medicine
2022
New York University
2016-2019
Cancer Genetics (United States)
2019
Columbia University Irving Medical Center
2019
National University of San Luis
2007
We found that the cancerous pancreas harbors a markedly more abundant microbiome compared with normal in both mice and humans, select bacteria are differentially increased tumorous gut. Ablation of protects against preinvasive invasive pancreatic ductal adenocarcinoma (PDA), whereas transfer from PDA-bearing hosts, but not controls, reverses tumor protection. Bacterial ablation was associated immunogenic reprogramming PDA microenvironment, including reduction myeloid-derived suppressor cells...
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with limited treatment options. Although metabolic reprogramming hallmark of many cancers, including PDA, previous attempts to target changes therapeutically have been stymied by drug toxicity and tumour cell plasticity. Here, we show that PDA cells engage an eIF4F-dependent translation program supports redox central carbon metabolism. Inhibition the eIF4F subunit, eIF4A, using synthetic rocaglate CR-1-31-B (CR-31) reduced...
Abstract The drivers and the specification of CD4 + T cell differentiation in tumor microenvironment their contributions to immunity or tolerance are incompletely understood. Using models pancreatic ductal adenocarcinoma (PDA), we show that a distinct subset tumor-infiltrating dendritic cells (DC) promotes PDA growth by directing unique H -program. Specifically, CD11b CD103 − DC predominate PDA, express high IL-23 TGF-β, induce FoxP3 neg tumor-promoting IL-10 IL-17 IFNγ regulatory cells....
Abstract Con A hepatitis is regarded as a T cell–mediated model of acute liver injury. Mincle C-type lectin receptor that critical in the immune response to mycobacteria and fungi but does not have well-defined role preclinical models non-pathogen–mediated inflammation. Because can ligate cell death ligand SAP130, we postulated signaling drives intrahepatic inflammation injury hepatitis. Acute was assessed murine using C57BL/6, Mincle−/−, Dectin-1−/− mice. The C/EBPβ hypoxia-inducible...
Activated B cell-like diffuse large B-cell lymphomas (ABC-DLBCL) have unfavorable outcomes and chronic activation of CARD11-BCL10-MALT1 (CBM) signal amplification complexes that form due to polymerization BCL10 subunits, which is affected by recurrent somatic mutations in ABC-DLBCLs. Herein, we show mutants fall into at least two functionally distinct classes: missense the CARD domain truncation its C-terminal tail. Truncating abrogated a motif through MALT1 inhibits polymerization, trapping...
Objectives: To study the role of IL‐12p40 at onset reactive arthritis (ReA) after Yersinia enterocolitica O:3 infection, and analyse relevant microbial antigens articular expression Toll‐like receptor (TLR) mRNA.Methods: Wild‐type C57BL/6 IL‐12p40‐deficient (IL‐12p40‐/‐) mice were orogastrically infected with Y. O:3. Early (day 3) late 21) number bacteria determined in Peyer's patches (PP), mesenteric lymph nodes (MLN), spleen, joints. Histological studies joints performed. Collagen‐specific...
<p>Figure Legends for Figures S1-S8.</p>
<p>Supplementary Figures 1-8.</p>
<div>Abstract<p>Activated B cell–like diffuse large B-cell lymphomas (ABC-DLBCL) have unfavorable outcomes and chronic activation of CARD11–BCL10–MALT1 (CBM) signal amplification complexes that form due to polymerization BCL10 subunits, which is affected by recurrent somatic mutations in ABC-DLBCLs. Herein, we show mutants fall into at least two functionally distinct classes: missense the CARD domain truncation its C-terminal tail. Truncating abrogated a motif through MALT1...
<p>Supplementary Figures 1-8.</p>
<p>Figure Legends for Figures S1-S8.</p>
<div>Abstract<p>Activated B cell–like diffuse large B-cell lymphomas (ABC-DLBCL) have unfavorable outcomes and chronic activation of CARD11–BCL10–MALT1 (CBM) signal amplification complexes that form due to polymerization BCL10 subunits, which is affected by recurrent somatic mutations in ABC-DLBCLs. Herein, we show mutants fall into at least two functionally distinct classes: missense the CARD domain truncation its C-terminal tail. Truncating abrogated a motif through MALT1...
Supplementary Figure from <i>BCL10</i> Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL
Supplementary Data from <i>BCL10</i> Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL
Supplementary Data from <i>BCL10</i> Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL
Supplementary Data from <i>BCL10</i> Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL
Supplementary Figure from <i>BCL10</i> Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL
Supplementary Data from <i>BCL10</i> Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL
Supplementary Data from <i>BCL10</i> Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL
Supplementary Data from <i>BCL10</i> Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL
<div>Abstract<p>We found that the cancerous pancreas harbors a markedly more abundant microbiome compared with normal in both mice and humans, select bacteria are differentially increased tumorous gut. Ablation of protects against preinvasive invasive pancreatic ductal adenocarcinoma (PDA), whereas transfer from PDA-bearing hosts, but not controls, reverses tumor protection. Bacterial ablation was associated immunogenic reprogramming PDA microenvironment, including reduction...