A5037852116- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- Extracellular vesicles in disease
- Cell death mechanisms and regulation
- Galectins and Cancer Biology
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- International Student and Expatriate Challenges
- Nanoplatforms for cancer theranostics
- Neuroendocrine Tumor Research Advances
- T-cell and B-cell Immunology
- Pancreatic function and diabetes
- Cancer Research and Treatments
- Gastrointestinal disorders and treatments
- Autophagy in Disease and Therapy
- Diabetes Treatment and Management
- Gallbladder and Bile Duct Disorders
- Gender Diversity and Inequality
Technische Universität Dresden
2020-2025
German Cancer Research Center
2020-2025
Heidelberg University
2019-2025
University Hospital Carl Gustav Carus
2016-2025
National Center for Tumor Diseases
2021-2025
Helmholtz-Zentrum Dresden-Rossendorf
2022-2025
University Hospital Münster
2024
Deutschen Konsortium für Translationale Krebsforschung
2020-2023
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2018-2023
University Hospital Heidelberg
2019-2023
Modulation of Toll-like receptor (TLR) signaling can have protective or protumorigenic effects on oncogenesis depending the cancer subtype and specific inflammatory elements within tumor milieu. We found that TLR9 is widely expressed early during course pancreatic transformation ligands are ubiquitous microenvironment. ligation markedly accelerates oncogenesis, whereas deletion protective. show activation has distinct epithelial, inflammatory, fibrogenic cellular subsets in carcinoma plays a...
Plasmacytoid dendritic cells (pDCs) play a key role in the induction and maintenance of antitumor immunity. Conversely, they can act as tolerogenic DCs by inhibiting tumor-directed immune responses. Therefore, pDCs may profoundly influence tumor progression. To gain novel insights into colon cancer, we investigated frequency clinical relevance primary tissues from patients with cancer different clinicopathological characteristics.Immunohistochemical stainings were performed to explore...
Abstract Pancreatic ductal adenocarcinoma (PDAC) responds poorly to checkpoint blockade, such as anti-CTLA-4 and anti-PD-1. Galectin-9, a β-galactoside-binding lectin, promotes immune suppression through T-cell inhibition, programming of tolerogenic macrophages. Of all cancers tested, PDAC showed the highest expression LGALS9 (galectin-9) mRNA. We analyzed formalin-fixed paraffin-embedded specimens from 83 patients with stained for galectin-9. Using flow cytometry, we determined galectin-9...
During obesity, macrophages infiltrate the visceral adipose tissue and promote inflammation that contributes to type II diabetes. Evidence suggests rewiring of cellular metabolism can regulate macrophage function. However, metabolic programs characterize (ATM) in obesity are poorly defined. Here, we demonstrate ATM from obese mice exhibit profiles characterized by elevated glycolysis oxidative phosphorylation, distinct lean mice. Increased activation HIF-1α resulted induction IL-1β genes...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) exhibits a high frequency of neural invasion (NI). Schwann cells (SCs) have been shown to be reprogrammed facilitate cancer cell migration and into nerves. Since extracellular vesicles (EVs) affect the tumour microenvironment promote metastasis, present study analysed involvement EVs from pancreatic their in altering SC phenotype as part early events process NI. Methods were isolated human/murine PDAC cells, stellate (PSCs), human...
Dectin-1 is a C-type lectin receptor critical in anti-fungal immunity, but has not been linked to regulation of sterile inflammation or oncogenesis. We found that expression upregulated hepatic fibrosis and liver cancer. However, deletion exacerbates fibro-inflammatory disease accelerates hepatocarcinogenesis. Mechanistically, we protects against chronic by suppressing TLR4 signaling inflammatory stellate cells. Accordingly, Dectin-1(-/-) mice exhibited augmented cytokine production reduced...
T cells are the predominant immune cell population in pancreatic tumor microenvironment. High CD8+ and Th1-polarized CD4+ infiltration is associated with prolonged survival human ductal adenocarcinoma (PDAC). However, expression pattern of co-stimulatory inhibitory receptors by PDAC-infiltrating their prognostic significance not well defined. In this study, we employed multiplex immunofluorescence to investigate intratumoral receptor inducible T-cell co-stimulator (ICOS),...
The prognosis of pancreatic ductal adenocarcinoma (PDAC) is one the most dismal all cancers and median survival PDAC patients only 6-8 months after diagnosis. While decades research effort have been focused on early diagnosis understanding molecular mechanisms, few clinically useful markers universally applied. To improve treatment management PDAC, it equally relevant to identify prognostic factors for optimal therapeutic decision-making patient survival. Compelling evidence suggested...
In this much-needed study, Joseph Harris bridges the gap between two distinct approaches to cross-dressing. On one hand, literary scholars have long recognized fascination with topic in seventeenth-century French literature and culture, but often without consideration of its implications for gender ideologies. other, post-structuralist theorists given a prominent place drag as both practice model, usually from presentist outlook. Fully versed bringing each bear on has made an important...
The treatment of colorectal cancer (CRC) has improved during the last decades, but methods for crucial early diagnosis are yet to be developed. influence tumour microenvironment on liquid biopsies diagnostics gaining growing interest, especially with emphasis exosomes (EXO), a subgroup extracellular vesicles (EVs). In this study, we established paired cancer-associated (CAFs) and normal fibroblasts (NF) from 13 CRC patients investigated activation status-related protein abundance in derived...
Abstract Molecular reprogramming of stromal microarchitecture by tumour-derived extracellular vesicles (EVs) is proposed to favour pre-metastatic niche formation. We elucidated the role extravesicular tissue inhibitor matrix metalloproteinase-1 (TIMP1 EV ) in pro-invasive (ECM) remodelling liver microenvironment aid tumour progression colorectal cancer (CRC). Immunohistochemistry analysis revealed a high expression TIMP1 invasion front that was associated with poor progression-free survival...
Dendritic cells (DCs) play a key role in the orchestration of antitumor immunity. Activated DCs efficiently enhance effects mediated by natural killer and T lymphocytes. Conversely, tolerogenic essentially contribute to an immunosuppressive tumor microenvironment. Thus, can profoundly influence progression clinical outcome patients. To gain novel insights into human pancreatic ductal adenocarcinoma (PDAC), we explored frequency, spatial organization, significance conventional type 1 (cDC1s)...
The goal of this study was to develop and validate a short version (TMIC-S) the Test Measure Intercultural Competence (TMIC; Schnabel, Kelava, Seifert, & Kuhlbrodt, 2015). TMIC-S measures six malleable abilities that support handling novel or difficult cross-cultural situations. version, comprising 25 self-report situational judgment items, administered 1032 Germans 769 Brazilians. Confirmatory factor analysis (CFA) showed good fit sixfactor multimethod model in both samples. Measurement...
Abstract Purpose: Immunotherapy has led to a fundamental shift in the treatment of several cancers. However, its efficacy pancreatic ductal adenocarcinoma (PDAC) is limited. Understanding expression inhibitory immune checkpoint receptors (ICR) by intratumoral T cells may help unravel their involvement insufficient T-cell–mediated antitumor immunity. Experimental Design: Using multicolor flow cytometry, we analyzed circulating and from blood (n = 144) matched tumor samples 107) patients with...
Abstract Con A hepatitis is regarded as a T cell–mediated model of acute liver injury. Mincle C-type lectin receptor that critical in the immune response to mycobacteria and fungi but does not have well-defined role preclinical models non-pathogen–mediated inflammation. Because can ligate cell death ligand SAP130, we postulated signaling drives intrahepatic inflammation injury hepatitis. Acute was assessed murine using C57BL/6, Mincle−/−, Dectin-1−/− mice. The C/EBPβ hypoxia-inducible...
BACKGROUND. Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. At diagnosis, only 20% of patients with PDAC are eligible for primary resection. Neoadjuvant chemotherapy can enable surgical resection in 30%–40% locally advanced and borderline resectable PDAC. The effects neoadjuvant on the cytokine production tumor-infiltrating T cells unknown
Objective: To quantify and characterize preoperative blood T cells in patients with pancreatic ductal adenocarcinoma (PDAC), who underwent tumor resection, to determine their relevance as biomarkers for postoperative pancreas-specific complications. Background: Pancreas-specific complications after surgery are associated a high morbidity mortality, which both deprive of adjuvant chemotherapy. Noninvasive risk prediction missing, the role stratification is unknown. Methods: The frequency cell...
Abstract Background Biliary-enteric anastomosis (BEA) can be performed using continuous or interrupted suture techniques, but high-quality evidence regarding superiority of either technique is lacking. The aim this study was to compare the techniques for patients undergoing BEA by evaluating time as well short- and long-term biliary complications. Methods In single-centre randomized clinical trial, scheduled elective open procedure with a between 21 January 2016 20 September 2017 were...
Immunotherapy has shown promising results in multiple solid tumors and hematological malignancies. However, pancreatic ductal adenocarcinoma (PDAC) been largely refractory to current clinical immunotherapies. The V-domain Ig suppressor of T-cell activation (VISTA) inhibits effector function maintains peripheral tolerance. Here, we determine VISTA expression nontumorous (n = 5) PDAC tissue using immunohistochemistry 76) multiplex immunofluorescence staining 67). Additionally, on...
Interkulturelle Kompetenz wird als globale Verhaltensorientierung mit mehrdimensionaler Struktur verstanden. Auf dieser Basis wurde der Test zur Messung Interkultureller (TMIK) entwickelt, anhand von Selbsteinschätzungs- und Situationsbeurteilungsitems die differenzierte interkultureller ermöglicht. An n 1 = 641 Studierenden wurden Messeigenschaften Skala sowie Ausprägung in Abhängigkeit vier Außenkriterien überprüft. Eine Stichprobe 2 313 Berufstätigen diente Konstruktvalidierung...