A5015001740- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Retinal Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Ocular Oncology and Treatments
- Retinal and Macular Surgery
- Sarcoma Diagnosis and Treatment
- Renal and related cancers
- Neurogenesis and neuroplasticity mechanisms
- Melanoma and MAPK Pathways
- Renal cell carcinoma treatment
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Tryptophan and brain disorders
- Retinal and Optic Conditions
- Nanoplatforms for cancer theranostics
- Cancer Genomics and Diagnostics
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
- Cancer-related Molecular Pathways
- Neurogenetic and Muscular Disorders Research
- Vascular Tumors and Angiosarcomas
Polish Academy of Sciences
2015-2024
Mossakowski Medical Research Institute, Polish Academy of Sciences
2012-2024
Institute of Biocybernetics and Biomedical Engineering
2020-2021
Wojskowy Instytut Medycyny Lotniczej
2019
University of Tübingen
2009-2014
Zero to Three
2011
TH Bingen University of Applied Sciences
2008
STZ eyetrial
2008
University of Warsaw
2004
<h3>Background/Aims:</h3> To evaluate the retinal toxicity of Brilliant Blue G (BBG) following intravitreal injection in rat eyes and examine biocompatibility staining properties humans. <h3>Methods:</h3> BBG was injected into 11 to toxic effects with balanced salt solution (BSS) serving as control. Retinal assessed by ganglion cell (RGC) counts light microscopy 7 days later. In addition, applied during vitrectomy for macular hole (MH) (n = 15) or epiretinal membranes (ERM) 3) a prospective,...
Myocardial infarction (MI) is one of the most frequent causes death in industrialized countries. Stem cells therapy seems to be very promising for regenerative medicine. Skeletal myoblasts transplantation into postinfarction scar has been shown effective failing heart but shows limitations such, e.g. cell retention and survival. We synthesized investigated superparamagnetic iron oxide nanoparticles (SPIONs) as an agent direct labeling, which can used stem imaging. High quality, monodisperse...
Selective breeding of laboratory rats resulted in changes their behavior. Concomitantly, the albino strains developed vision related pathologies. These alterations certainly occurred on background modifications brain morphology. The aim study was to assess and compare volumes major structures brains wild-captive, pigmented rats. High resolution T2-weighted images adult male Warsaw Wild Captive Pisula-Stryjek (WWCPS, a model wild type), (Brown Norway strain, BN) (Wistar WI) were obtained with...
Molecular biology studies of uveal melanoma have resulted in the development novel immunotherapy approaches including tebentafusp—a T cell–redirecting bispecific fusion protein. More biomarkers are currently being studied. As a result, combined is developed as well with bifunctional checkpoint inhibitory cell engagers and natural killer cells. Current trials cover tumor-infiltrating lymphocytes (TIL), vaccination IKKb-matured dendritic cells, or autologous cells loaded tumor RNA. Another...
To investigate the intraocular effect of rhodamine 6G (R6G) on retinal structures and function in an vivo rat model to develop method for accurate evaluation new dyes surgery.R6G physiologic saline solution (PSS) was injected into vitreous adult Brown Norway rats at concentrations 0.0002%, 0.002%, 0.02%, 0.2%, 0.5%. Control animals received only PSS. Retinal toxicity assessed by ganglion cell (RGC) counts, light microscopy 7 days later, photopic electroretinography (ERG), measurement...
This study investigated the effects of systemically administered lithium acetoacetate (ACA) and sodium β-hydroxybutyrate (BHB) in a rat model N-methyl-D-aspartate (NMDA)-induced damage retinal ganglion cells (RGC). Additionally, influence ACA BHB on kynurenic acid (KYNA) production was assessed vitro bovine slices.Female adult Brown-Norway rats groups 5-8 animals were used. intraperitoneally once day for 21 consecutive days, phosphate buffered saline (PBS) to control animals. After 2 weeks,...
To evaluate the effects of intravitreally introduced vascular endothelial growth factor (VEGF) inhibitors in rat eyes with healthy retinal ganglion cells (RGC) and into others N-methyl-D-aspartate (NMDA)-induced RGC damage.Bevacizumab, ranibizumab pegaptanib were injected each at two different concentrations. Respective vehicles three substances served as controls. In a group, additionally anti-VEGF antibody was after NMDA treatment. Retrogradely labelled counted on wholemounts 1 week or 2...
Mn-Based gellan gum hydrogels for cell delivery and real-time tracking on image-guided neuro-procedures.
Clear cell renal carcinoma (ccRCC) is the most common kidney cancer. Prognosis for ccRCC generally poor since it largely resistant to chemo- and radiotherapy. Many studies suggested that cancer stem cells/tumor initiating cells (CSCs/TICs) are responsible development of tumor, disease progression, aggressiveness, metastasis drug resistance. However, tumorigenic potential CSCs/TICs isolated from established RCC lines - basic research model has never been investigated in vivo. CD105+, CD105-,...
To estimate protective potential of citicoline in a model birth asphyxia, the drug was given to 7-day old rats subjected permanent unilateral carotid artery occlusion and exposed for 65 min hypoxic gas mixture. Daily doses 100 or 300 mg/kg, vehicle, were injected intraperitoneally 7 consecutive days beginning immediately after end ischemic-hypoxic insult, brain damage assessed by gross zorphology score weight deficit two weeks insult. Caspase-3, α-fodrin, Bcl-2, Hsp70 levels at 0, 1, 24 h...
Objective: Proton magnetic resonance spectroscopy (1H-MRS) in ultra-high field can be used for non-invasive quantitative assessment of brain glutamate (Glu) and glutamine (Gln) vivo. Glu, the main excitatory neurotransmitter central nervous system, is efficiently recycled between synapses presynaptic terminals through Glu-Gln cycle which involves synthase confined to astrocytes, uses 60-80% energy resting human rat brain. During voluntary or involuntary exercise many areas are significantly...
Kynurenines, products of tryptophan (TRP) metabolism, display neurotoxic (eg. 3-hydroxykynurenine; 3-HK) or neuroprotective kynurenic acid; KYNA) properties. Imbalance between the enzymes constituting kynurenine pathway (KP) plays a role in several disease, including neurodegeneration. In this study, we track changes concentrations and its selected metabolites after damage to retinal ganglion cells link data with expression KP enzymes. Brown-Norway rats were subjected intravitreal...