A5036860161- Neurogenetic and Muscular Disorders Research
- Nerve injury and regeneration
- Amyotrophic Lateral Sclerosis Research
- Neurogenesis and neuroplasticity mechanisms
- Wound Healing and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Bee Products Chemical Analysis
- Silk-based biomaterials and applications
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Multiple Sclerosis Research Studies
- Antimicrobial Peptides and Activities
- Spinal Cord Injury Research
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Neonatal Respiratory Health Research
- Adenosine and Purinergic Signaling
- Mesenchymal stem cell research
- Infant Nutrition and Health
- Adipose Tissue and Metabolism
- Cerebrovascular and genetic disorders
- Moyamoya disease diagnosis and treatment
Mossakowski Medical Research Institute, Polish Academy of Sciences
2016-2025
Polish Academy of Sciences
2016-2025
Institute of Fundamental Technological Research
2013
Monilek Hospital and Research Center
2013
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2000-2009
Universität Hamburg
2002
Chondrosarcoma, the second most common primary malignant bone tumor, originates from cartilaginous tissue and accounts for almost 20% of all tumors. The management chondrosarcoma remains challenging due to its diverse clinical course prognosis, which can range benign highly aggressive with a huge risk metastasis. Emerging research has demonstrated importance microRNA (miRNA) dysregulation in pathogenesis chondrosarcoma. MiRNAs are small, noncoding RNA molecules that play an essential role...
Abstract Background It has been postulated that exercise-induced activation of brain-derived neurotrophic factor (BDNF) may account for improvement stepping ability in animals after complete spinal cord transection. As we have shown previously, treadmill locomotor exercise leads to up-regulation BDNF protein and mRNA the entire neuronal network intact cord. The questions arise: (i) how training, supplemented with tail stimulation, affects expression molecular correlates synaptic plasticity...
Keratin is a cytoskeletal scaffolding protein essential for wound healing and tissue recovery. The aim of the study was to evaluate potential role insoluble fur keratin-derived powder containing silver nanoparticles (FKDP-AgNP) in allogenic full-thickness surgical skin model diabetic mice. scanning electron microscopy image evidenced that keratin surface covered by single layer nanoparticles. Data obtained from dynamic light scattering micellar electrokinetic chromatography showed three...
Over the last three decades, dynamically evolving research using novel technologies, including virtual environments (VEs), has presented promising solutions for neuroscience and neuropsychology. This article explores known potential benefits drawbacks of employing modern technologies diagnosing treating developmental disorders, exemplified by autism spectrum disorder (ASD). ASD's complex nature is ideal illustrating advantages disadvantages digital world. While VEs' possibilities remain...
Human neural stem/progenitor cells (hNSCs) can potentially treat neurological diseases, but their low survival and proliferation rates after transplantation remain challenging. In our study, we preincubated hNSCs with the human cerebrospinal fluid (CSF) to obtain closer physiological brain environment assess NSC fate therapeutic abilities in vitro, ex vivo, vivo. We observed significant changes differentiation, migratory, secretory potential of CSF-treated hNSCs, as well elevated...
Abstract Keratin is an interesting protein needed for wound healing and tissue recovery. We have recently proposed a new, simple inexpensive method to obtain fur hair keratin‐derived biomaterials suitable medical application. The aim of the study was evaluate role (FKDP) dressing in allogenic full‐thickness surgical skin model. data obtained using scanning electron microscopy showed that employed processed biomaterial had higher surface porosity compared with control raw material. From MTS...
Summary Purpose: Status epilepticus (SE) has deleterious effects on brain tissue, but whether brief recurrent seizures may also damage neurons represents a matter of controversy. Therefore, it remains central area epilepsy research to identify individuals at risk where disease progression can be potentially prevented. Biomarkers serve as tools for such identification. Thus the present study aimed analyzing levels heat shock protein 70 (HSP‐70, designated HSPA1A) and neurofilament heavy chain...
Impaired wound healing is a major medical challenge, especially in diabetics. Over the centuries, main goal of tissue engineering and regenerative medicine has been to invent biomaterials that accelerate process. In this context, keratin-derived biomaterial promising candidate due its biocompatibility biodegradability. study, we evaluated an insoluble fraction keratin containing casomorphin as dressing full-thickness surgical skin model mice (n = 20) with iatrogenically induced diabetes....
Currently, the number of stem-cell based experimental therapies in neurological injuries and neurodegenerative disorders has been massively increasing. Despite fact that we still have not obtained strong evidence mesenchymal stem/stromal cells' neurogenic effectiveness vivo, research may need to focus on more appropriate sources result therapeutically promising cell populations. In this study, used dedifferentiated fat cells (DFAT) are proven demonstrate pluripotent abilities comparison with...
This work presents the successful synthesis of a library novel peptidomimetics via Ugi multicomponent reaction. Most these contain differently substituted aminocoumarin; 7-amino-4-methylcoumarin and 7-amino-4-(trifluoromethyl) coumarin. Inspired by biological properties coumarin derivatives peptidomimetics, we proposed incorporated peptidomimetics. We studied potential synthesized compounds as antimicrobial drugs on model E. coli bacterial strains (k12 R2-R4). To highlight importance in...
Background: High heterogeneity of mesenchymal stem/stromal cells (MSCs) due to different degrees differentiation cell subpopulations poses a considerable challenge in preclinical studies. The at pluripotent-like stage represent stem population interest for many researchers worldwide, which is worthy identification, isolation, and functional characterization. In the current study, we asked whether Wharton’s jelly-derived MSCs (WJ-MSCs) express stage-specific embryonic antigen-4 (SSEA-4) can...
AMA Dąbrowska-Bouta B, Sulkowski G, Frontczak-Baniewicz M, Sulejczak D, Strużyńska L. Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats. Folia Neuropathologica. 2024;62(1):1-12. doi:10.5114/fn.2023.133796. APA Dąbrowska-Bouta, B., Sulkowski, G., Frontczak-Baniewicz, M., Sulejczak, D., & Strużyńska, (2024). Neuropathologica, 62(1), 1-12. https://doi.org/10.5114/fn.2023.133796 Chicago...