A5083698114- Chemical Synthesis and Analysis
- Enzyme Catalysis and Immobilization
- Multicomponent Synthesis of Heterocycles
- Carbohydrate Chemistry and Synthesis
- Molecular Sensors and Ion Detection
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Reactions
- Click Chemistry and Applications
- Synthetic Organic Chemistry Methods
- Asymmetric Hydrogenation and Catalysis
- Analytical Chemistry and Sensors
- Microbial Natural Products and Biosynthesis
- Electrochemical sensors and biosensors
- Sulfur Compounds in Biology
- Cyclopropane Reaction Mechanisms
- Mass Spectrometry Techniques and Applications
- Synthesis and biological activity
- Organophosphorus compounds synthesis
- Microbial Metabolic Engineering and Bioproduction
- Oxidative Organic Chemistry Reactions
- Inorganic and Organometallic Chemistry
- Porphyrin and Phthalocyanine Chemistry
- Luminescence and Fluorescent Materials
- Synthesis and Biological Evaluation
- Neuroscience of respiration and sleep
Polish Academy of Sciences
2016-2025
Institute of Organic Chemistry
2016-2025
Kielanowski Institute of Animal Physiology and Nutrition
2022-2025
University of Warsaw
2015-2018
University of Twente
1991-2017
University of Zurich
2014-2017
National Veterinary Research Institute
1993-2016
University of Graz
2016
Łukasiewicz Research Network - Industrial Chemistry Institute
2012
Warsaw University of Technology
2000-2006
Multicomponent reactions are powerful tools for organic chemistry, and among them, the Ugi reaction provides remarkable improvement in many fields of chemistry such us combinatorial medicinal peptide chemistry. A new, enzyme-catalyzed example three-component is presented. The studies include selection an enzyme as well determination scope limitations newly described reaction. presented method combines promiscuity multicomponent advantages first one-pot formation dipeptide 1.
The purpose of the present study was to evaluate synergistic effect two important pharmacophores, 3,4-dihydroxyphenyl and peptidomimetic moieties, as mushroom tyrosinase inhibitors antimicrobial agents targeting specific strains pathogenic bacteria. 3,4-dihydroxybenzaldehyde (protocatechuic aldehyde) found be an effective inhibitor activity, due fact that it is a safe natural substance with such scaffolded structure, likely dihydroxyl-substituted phenolic derivatives can exhibit potent...
// Anna Trzeciecka 1 , Szymon Klossowski 2 Malgorzata Bajor Radoslaw Zagozdzon 1, 3 Pawel Gaj Angelika Muchowicz Agata Malinowska 4 Czerwoniec 5 Joanna Barankiewicz 6 Antoni Domagala Justyna Chlebowska 7 Monika Prochorec-Sobieszek 8, 9 Magdalena Winiarska Ryszard Ostaszewski Iwonna Gwizdalska 10 Jakub Golab Dominika Nowis 7, 11 Firczuk Department of Immunology, Medical University Warsaw, Poland Institute Organic Chemistry, Polish Academy Sciences, Bioinformatics, Biochemistry and Biophysics,...
The formation of α-acyloxy carboxamides from a carboxylic acid, an aldehyde and isocyanide (Passerini reaction) was investigated in aqueous solution the presence different types surfactants.
The objective of the present study was to evaluate synergistic effect two important pharmacophores, coumarin and α-amino dimethyl phosphonate moieties, on antimicrobial activity toward selected LPS-varied E. coli strains. Studied agents were prepared via a Kabachnik-Fields reaction promoted by lipases. products provided with an excellent yield (up 92%) under mild, solvent- metal-free conditions. A preliminary exploration analogs as novel carried out determine basic features structure...
The first example of applying salicylaldehyde derivatives, as well coumarin with the formyl group at C8 position in its structure, carbonyl partners a three-component Passerini reaction, is presented. As result research on conditions important role hydroxyl used course multicomponent reaction was revealed. When an aldehyde unprotected used, only two-component α-hydroxy amide products are obtained. In contrast, use acylated results α-acyloxy high efficiency. developed protocol gives access to...
Lactones are among the well-known organic substances with a specific taste and smell. They characterized by antibacterial, antiviral, anti-inflammatory, anti-cancer properties. In recent years, this group of compounds, new biologically active have been searched modifying main (leading) structure analogs stronger or different responses that may toxic effect on cells pathogenic bacteria constitute an alternative to commonly used antibiotics. A preliminary study δ-lactone derivatives as...
An enzymatic route for phosphorous-carbon- bond formation is developed by discovering new promiscuous activity of lipase. This biocatalytic transformation addition leads to biologically and pharmacologically relevant α-acyloxy phosphonates with methyl group in α-position. A series target compounds were synthesized yields ranging from 54% 83% reaction Candida cylindracea (CcL) lipase via Markovnikov H-phosphites vinyl esters. We carefully analyzed the best conditions given such as type...
We reported a new method dealing with the synthesis of novel pharmacologically relevant α-aminophosphonate derivatives via lipase-catalyzed Kabachnik−Fields reaction yields up to 93%. The advantages this protocol are excellent yields, mild conditions, low costs, and sustainability. developed is applicable range H-phosphites organic amines, providing wide substrate scope. A class analogues possessing P-chiral centers was also synthesized. synthesized compounds were characterized on basis...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetically stable complexes of alkali cations with calixspherands: an evaluation shieldingWouter I. Iwema Bakker, Marijke Haas, Corinne Khoo-Beattie, Ryszard Ostaszewski, Sybille M. Franken, Herman J. den Hertog Jr., Willem Verboom, Dick de Zeeuw, Sybolt Harkema, and David N. ReinhoudtCite this: Am. Chem. Soc. 1994, 116, 1, 123–133Publication Date (Print):January 1994Publication History Published online1 May 2002Published inissue 1 January...
MG-132 is a tripeptide aldehyde (Z-l-leu-l-leu-l-leu-H, 2) proteasome inhibitor that exerts antitumor activity and enhances cytostatic/cytotoxic effects of chemo- radiotherapy. Because troublesome synthesis tripeptides with non-natural configuration modified side chains amino acids, only two stereoisomers have been reported. Here, we propose new approach to the aldehydes based on Ugi reaction. Chiral, enantiomerically stable 2-isocyano-4-methylpentyl acetates were used as substrates for...
Thioredoxins (Trx) are ubiquitous multifunctional low-molecular weight proteins that together with thioredoxin reductases (TrxR) participate in the maintenance of protein thiol homeostasis NADPH-dependent reactions. An increasing number data reveal Trx–TrxR system is an attractive target for anticancer therapies. In this work, we have elaborated a new and simple synthetic approach employing Ugi reaction to synthesize several inhibitors system. The influence various electrophilic fragments...
A new, alternative route for the synthesis of a variety α-aminoacyl amides <italic>via</italic> four-component Ugi reaction in presence different surfactants aqueous solution was investigated. High yields were obtained many cases with vesicles formed from DDAB.