A5013582030- Neuroscience and Neuropharmacology Research
- Heavy Metal Exposure and Toxicity
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Multiple Sclerosis Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Nanoparticles: synthesis and applications
- Adenosine and Purinergic Signaling
- Mitochondrial Function and Pathology
- Trace Elements in Health
- Cardiac Arrest and Resuscitation
- Neurogenesis and neuroplasticity mechanisms
- Biochemical effects in animals
- Ion channel regulation and function
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- thermodynamics and calorimetric analyses
- Alzheimer's disease research and treatments
- S100 Proteins and Annexins
- RNA regulation and disease
- Systemic Lupus Erythematosus Research
- Advanced Biosensing Techniques and Applications
- Mast cells and histamine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Barrier Structure and Function Studies
Polish Academy of Sciences
2016-2025
Mossakowski Medical Research Institute, Polish Academy of Sciences
2009-2020
Institute of Cytochemistry and Molecular Pharmacology
2015
Uniformed Services University of the Health Sciences
2013
Laboratory of Molecular Genetics
1999
The pathogenesis of spinal cord injury (SCI) remains poorly understood and treatment limited. Emerging evidence indicates that post-SCI inflammation is severe but the role reactive astrogliosis not well given its implication in ongoing as damaging or neuroprotective. We have completed an extensive systematic study with MRI, histopathology, proteomics ELISA analyses designed to further define protracted after SCI a rat model. identified 3 distinct phases SCI: acute (first 2 days),...
Numerous studies on lead (Pb) neurotoxicity have indicated this metal to be a dangerous toxin, particularly during developmental stages of higher organisms. Astrocytes are responsible for sequestration in brain tissue. Activation astroglia may often loss the buffering function and contribute pathological processes. This phenomenon is accompanied by death neuronal cells connected with inflammatory events arising from production wide range cytokines chemokines. The effects prolonged exposure...
Currently, silver nanoparticles (AgNPs) are frequently used in a wide range of medical and consumer products. Substantial usage AgNPs is considered to create substantive risks both the environment human health. Since there increasing evidence that main mechanism toxicity relates oxidative stress, current study we investigate stress-related biochemical parameters myelin isolated from adult rat brain subjected low dose AgNPs. Animals were exposed for 2 weeks 0.2 mg/kg b.w. small (10 nm)...
Abstract Extensive incorporation of silver nanoparticles (AgNPs) into many medical and consumer products has raised concerns about biosafety. Since nanosilver accumulates persistently in the central nervous system, it is important to assess its neurotoxic impacts. We investigated a model prolonged exposure adult rats low environmentally relevant dose AgNPs (0.2 mg/kg b.w.). Ultrastructural analysis revealed pathological alterations mitochondria such as swelling cristolysis. Besides,...
Transforming growth factor-βs (TGF-βs) are secreted from cells as latent complexes and the activity of TGF-βs is controlled predominantly through activation these complexes. Tolerance to fetal allograft essential for pregnancy success; TGF-β1 TGF-β2 play important roles in regulating processes. Pregnancy-specific β-glycoproteins (PSGs) present maternal circulation at a high concentration throughout have been proposed anti-inflammatory functions. We found that recombinant native PSG1 activate...
Abstract The continuous increase in plastic production has resulted increased generation of microplastic particles (MPs), and nanoplastic (NPs). Recent evidence suggests that nanoplastics may be a potent neurotoxin because they are able to freely cross the blood–brain barrier enter brain. Therefore, cytotoxic effects polystyrene nanoparticles (PS-NPs) on cellular systems cerebral origin should thoroughly investigated. aim current study is evaluate potential 25 nm PS-NPs vitro cultured cells...
The etiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. elevation glutamate cerebrospinal fluid, as well changes expression receptors (iGluRs and mGluRs) excitatory amino acid transporters (EAATs), have been observed brains MS patients animals subjected to experimental autoimmune encephalomyelitis (EAE), which predominant animal model used investigate pathophysiology MS. In present paper, effects...
Abnormalities of alpha-synuclein (ASN), the main component protein deposits (Lewy bodies), were observed in Parkinson's disease (PD), dementia with Lewy bodies, Alzheimer's disease, and other neurodegenerative disorders. These alterations include increase levels soluble ASN oligomers extracellular space. Numerous works have identified several mechanisms their toxicity, including stimulation microglial P2X7 receptor leading to oxidative stress. While significant role purinergic...
The growing production of silver nanoparticles (AgNPs), and their widespread use in medical consumer products, poses a potential threat to the environment raises questions about biosafety. Immature organisms are particularly susceptible various insults during development. biological characteristics immature different from those adults, dictate consequences exposure toxic substances, including AgNPs. Nanoparticles highly reactive can easily cross blood-brain barrier (BBB) accumulate brain...
Experimental autoimmune encephalomyelitis (EAE) is an animal model most commonly used in research on the pathomechanisms of multiple sclerosis (MS). The inflammatory processes, glutamate excitotoxicity, and oxidative stress have been proposed as determinants accompanying demyelination neuronal degeneration during course MS/EAE. aim current study was to characterize role NMDA receptors induction EAE. effect memantine, uncompetitive receptor antagonist, modulation neurological deficits EAE...
AMA Dąbrowska-Bouta B, Sulkowski G, Frontczak-Baniewicz M, Sulejczak D, Strużyńska L. Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats. Folia Neuropathologica. 2024;62(1):1-12. doi:10.5114/fn.2023.133796. APA Dąbrowska-Bouta, B., Sulkowski, G., Frontczak-Baniewicz, M., Sulejczak, D., & Strużyńska, (2024). Neuropathologica, 62(1), 1-12. https://doi.org/10.5114/fn.2023.133796 Chicago...
The aim of our investigation was to characterize the role group I mGluRs and NMDA receptors in pathomechanisms experimental autoimmune encephalomyelitis (EAE), rodent model MS. We tested effects LY 367385 (S-2-methyl-4-carboxyphenylglycine, a competitive antagonist mGluR1), MPEP (2-methyl-6-(phenylethynyl)-pyridine, an mGluR5), uncompetitive receptor antagonists amantadine memantine on modulation neurological deficits observed rats with EAE. symptoms EAE started at 10-11 days post-injection...