A5059801295- Mesenchymal stem cell research
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Pancreatic function and diabetes
- Spinal Dysraphism and Malformations
- Epigenetics and DNA Methylation
Polish Academy of Sciences
2021-2025
One of the key factors that may influence therapeutic potential mesenchymal stem/stromal cells (MSCs) is their metabolism. The switch between mitochondrial respiration and glycolysis can be affected by many factors, including oxygen concentration spatial form culture. This study compared metabolic features adipose-derived (ASCs) dedifferentiated fat (DFATs) cultivated as monolayer or spheroid culture under 5% O2 (physiological normoxia) impact on MSCs abilities.We observed cultured spheroids...
Energy metabolism homeostasis emerges as a dominant element influencing mesenchymal stem/stromal cells' trajectory of development. The predominant glycolysis activity is primary driver cell proliferation and maintenance the high-energetic state. Here, we examined functions two crucial auxiliary pathways: phosphate-pentose pathway (PPP) fructose-2,6-biphosphate (FBP) to evaluate their impact on therapeutic potential Adipose-Derived Stem/Stromal cells (ASCs) during prolonged culture in various...
Currently, the number of stem-cell based experimental therapies in neurological injuries and neurodegenerative disorders has been massively increasing. Despite fact that we still have not obtained strong evidence mesenchymal stem/stromal cells' neurogenic effectiveness vivo, research may need to focus on more appropriate sources result therapeutically promising cell populations. In this study, used dedifferentiated fat cells (DFAT) are proven demonstrate pluripotent abilities comparison with...
Skin, as a part of the innate immune system, represents first line defense against pathogens. Each mechanical damage to skin surface disrupts its homeostasis, thus rapidly inducing cascade repair processes. Wound healing comprises 4 subsequent and overlapping steps: hemostasis, inflammation, proliferation, remodeling. The interplay abovementioned phases results in successful cell restoration tissue repair. efficiency wound depends on numerous internal external factors. proper recruitment...
Abstract In the era of a constantly growing number reports on therapeutic properties dedifferentiated, ontogenetically rejuvenated cells and their use in treatment neurological diseases, optimization derivation long-term culture methods seem to be crucial. One solutions is seen dedifferentiated fat (DFATs) which are characterized by greater homogeneity. Moreover, these possess higher expression transcriptional factors necessary maintain pluripotency (STRFs) as well ability differentiate...
Treatment of hard-to-heal, chronic wounds, particularly in palliative patients or intensive care units, constitutes a significant issue. Due to the constant development this field medicine and numerous scientific reports, it is possible use variety techniques dressings difficult-to-heal wound treatment. However, promising strategy an alternative conventional may be transplantation cell-coated bio-scaffolds into wound. In addition keratinocytes fibroblasts transplants, which show healing...