A5035197878- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Diabetes and associated disorders
- NF-κB Signaling Pathways
- CAR-T cell therapy research
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Blood disorders and treatments
- RNA modifications and cancer
- IL-33, ST2, and ILC Pathways
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- Immune responses and vaccinations
- Genomics and Rare Diseases
- RNA regulation and disease
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
The Francis Crick Institute
2021-2024
Australian National University
2015-2024
Renji Hospital
2015-2024
Shanghai Jiao Tong University
2019-2024
Curtin University
2019-2024
Hackensack University Medical Center
2024
University at Buffalo, State University of New York
2024
Royal Society
2024
University of Cambridge
2023
Personalis (United States)
2021-2022
During T cell–dependent responses, B cells can either differentiate extrafollicularly into short-lived plasma or enter follicles to form germinal centers (GCs). Interactions with follicular helper (Tfh) are required for GC formation and selection of somatically mutated cells. Interleukin (IL)-21 has been reported play a role in Tfh cell growth, survival, isotype switching. To date, it is unclear whether the effect IL-21 on predominantly consequence this cytokine acting directly if influences...
Abstract Objective In the sanroque mouse model of lupus, pathologic germinal centers (GCs) arise due to increased numbers follicular helper T (Tfh) cells, resulting in high‐affinity anti–double‐stranded DNA antibodies that cause end‐organ inflammation, such as glomerulonephritis. The purpose this study was examine hypothesis pathway could account for a subset patients with systemic lupus erythematosus (SLE). Methods An expansion Tfh cells is causal, and therefore consistent, component...
The incidence of food allergies in western countries has increased dramatically recent decades. Tolerance to antigens relies on mucosal CD103(+) dendritic cells (DCs), which promote differentiation regulatory T (Treg) cells. We show that high-fiber feeding mice improved oral tolerance and protected from allergy. High-fiber reshaped gut microbial ecology the release short-chain fatty acids (SCFAs), particularly acetate butyrate. enhanced against allergy by enhancing retinal dehydrogenase...
Production of high-affinity pathogenic autoantibodies appears to be central the pathogenesis lupus. Because normal antibodies arise from germinal centers (GCs), aberrant selection GC B cells, caused by either failure negative or enhanced positive follicular helper T (T(FH)) is a plausible explanation for these autoantibodies. Mice homozygous san allele Roquin, which encodes RING-type ubiquitin ligase, develop GCs in absence foreign antigen, excessive T(FH) cell numbers, and features We...
Abstract Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling as a mechanism of human systemic autoimmune disease 1–7 , lupus-causing TLR7 gene variants is lacking. Here we describe lupus erythematosus caused by gain-of-function variant. sensor viral RNA 8 9 and binds to guanosine 10 – 12 . We identified de novo, previously undescribed missense Y264H variant in child with severe additional other patients lupus. The selectively increased sensing 2',3'-cGMP...
Regnase-1 and Roquin are RNA binding proteins essential for degradation of inflammation-related mRNAs maintenance immune homeostasis. However, their mechanistic relationship has yet to be clarified. Here, we show that, although regulate an overlapping set via a common stem-loop structure, they function in distinct subcellular locations: ribosome/endoplasmic reticulum processing-body/stress granules, respectively. Moreover, specifically cleaves degrades translationally active requires the...
T follicular helper cells (Tfh cells) localize to follicles where they provide growth and selection signals mutated germinal center (GC) B cells, thus promoting their differentiation into high affinity long-lived plasma memory cells. T-dependent cell also occurs extrafollicularly, giving rise unmutated that are important for early protection against microbial infections. Bcl-6 expression in has been shown be essential the formation of Tfh GC but little is known about its requirement...
The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on patient's life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into role genetics in prognosis. We identify noncoding polymorphism FOXO3A (rs12212067: T > G) at which minor (G) allele, despite not being associated with susceptibility, milder...